HUMAN:PAR16

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	No Information Provided.
Protein Name(s)	Mono [ADP-ribose] polymerase PARP16 (ECO:0000305) ADP-ribosyltransferase diphtheria toxin-like 15 (ECO:0000303 with PMID:20106667^[1]) Poly [ADP-ribose] polymerase 16 PARP-16
External Links
UniProt	Q8N5Y8
EMBL	AK000516 BC006389 BC031074
CCDS	CCDS10204.1
RefSeq	NP_060321.3 XP_005254573.1
UniGene	Hs.30634
PDB	4F0D
PDBsum	4F0D
ProteinModelPortal	Q8N5Y8
SMR	Q8N5Y8
BioGrid	120294
IntAct	Q8N5Y8
STRING	9606.ENSP00000261888
PhosphoSite	Q8N5Y8
BioMuta	PARP16
DMDM	116248565
MaxQB	Q8N5Y8
PaxDb	Q8N5Y8
PRIDE	Q8N5Y8
DNASU	54956
Ensembl	ENST00000261888
GeneID	54956
KEGG	hsa:54956
UCSC	uc002aoo.3 uc002aop.3 uc002aoq.3
CTD	54956
GeneCards	GC15M065550
HGNC	HGNC:26040
HPA	HPA017081
neXtProt	NX_Q8N5Y8
PharmGKB	PA134984504
eggNOG	NOG46092
GeneTree	ENSGT00390000014077
HOGENOM	HOG000253948
HOVERGEN	HBG058859
InParanoid	Q8N5Y8
KO	K00774
OMA	FHSILHN
PhylomeDB	Q8N5Y8
TreeFam	TF323413
BRENDA	2.4.2.30 2.4.2.31
GenomeRNAi	54956
NextBio	58144
PRO	PR:Q8N5Y8
Proteomes	UP000005640
Bgee	Q8N5Y8
CleanEx	HS_PARP16
ExpressionAtlas	Q8N5Y8
Genevisible	Q8N5Y8
GO	GO:0005783 GO:0005789 GO:0071782 GO:0016021 GO:0016020 GO:0005635 GO:0019900 GO:0003950 GO:0043539 GO:0006987 GO:0030968 GO:0060548 GO:0071902 GO:0006471 GO:0070213
Gene3D	3.90.228.10
InterPro	IPR012317
Pfam	PF00644
PROSITE	PS51059

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0140289	protein mono-ADP-ribosylation	PMID:25043379^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070213	protein auto-ADP-ribosylation	PMID:25043379^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990404	protein ADP-ribosylase activity	PMID:25043379^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9NZJ5) happens_during:(GO:0030968)\|has_direct_input(UniProtKB:O75460) happens_during:(GO:0030968)	Seeded From UniProt	complete
part_of	GO:0071782	endoplasmic reticulum tubular network	PMID:22701565^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070213	protein auto-ADP-ribosylation	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070213	protein auto-ADP-ribosylation	PMID:22701565^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0030968)	Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9NZJ5) happens_during:(GO:0030968)\|has_direct_input(UniProtKB:O75460) happens_during:(GO:0030968)	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:23103912^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:23103912^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZJ5	F		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:O75460)	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9NZJ5) happens_during:(GO:0030968)\|has_direct_input(UniProtKB:O75460) happens_during:(GO:0030968)	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:22701565^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q14974)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:22701565^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:22701565^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:23103912^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0071782	endoplasmic reticulum tubular network	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001848547 UniProtKB:Q8N5Y8	C		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001848547 UniProtKB:Q8N5Y8	F		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001848547 UniProtKB:Q8N5Y8	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001848547 UniProtKB:Q8N5Y8	F		Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000481687 UniProtKB:Q8N5Y8	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001848547 UniProtKB:Q8N5Y8	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001848547 UniProtKB:Q8N5Y8	C		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000481687 UniProtKB:Q8N5Y8	F		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TMM8 ensembl:ENSMUSP00000150318	P		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012317	F		Seeded From UniProt	complete
involved_in	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	Reactome:R-HSA-197264	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8938073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hottiger, MO et al. (2010) Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem. Sci. 35 208-19 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Vyas, S et al. (2014) Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun 5 4426 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 Jwa, M & Chang, P (2012) PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. Nat. Cell Biol. 14 1223-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Di Paola, S et al. (2012) PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. PLoS ONE 7 e37352 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20106667-1] Hottiger, MO et al. (2010) Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem. Sci. 35 208-19 PubMed GONUTS page

[PMID:25043379-2] 2.0 ^2.1 ^2.2 Vyas, S et al. (2014) Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun 5 4426 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:23103912-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 Jwa, M & Chang, P (2012) PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. Nat. Cell Biol. 14 1223-30 PubMed GONUTS page

[PMID:22701565-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Di Paola, S et al. (2012) PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. PLoS ONE 7 e37352 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:PAR16

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