HUMAN:PACA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ADCYAP1
Protein Name(s)	Pituitary adenylate cyclase-activating polypeptide PACAP PACAP-related peptide PRP-48 Pituitary adenylate cyclase-activating polypeptide 27 PACAP-27 PACAP27 Pituitary adenylate cyclase-activating polypeptide 38 PACAP-38 PACAP38
External Links
UniProt	P18509
EMBL	S83513 X60435 AK313050 BC093837 BC101803
CCDS	CCDS11825.1
PIR	I84638
RefSeq	NP_001093203.1 NP_001108.2
UniGene	Hs.531719 Hs.727476
PDB	1GEA 2D2P 2JOD
PDBsum	1GEA 2D2P 2JOD
ProteinModelPortal	P18509
SMR	P18509
BioGrid	106629
DIP	DIP-60936N
IntAct	P18509
MINT	MINT-2801501
STRING	9606.ENSP00000269200
BindingDB	P18509
ChEMBL	CHEMBL5692
PhosphoSite	P18509
DMDM	71159615
PaxDb	P18509
PRIDE	P18509
DNASU	116
Ensembl	ENST00000450565 ENST00000579794
GeneID	116
KEGG	hsa:116
UCSC	uc010dkg.3
CTD	116
GeneCards	GC18P000895
HGNC	HGNC:241
MIM	102980
neXtProt	NX_P18509
PharmGKB	PA24564
eggNOG	NOG39235
GeneTree	ENSGT00530000063592
HOVERGEN	HBG018069
InParanoid	P18509
KO	K05262
OMA	ADGIFNK
OrthoDB	EOG7M6D8P
PhylomeDB	P18509
TreeFam	TF332804
Reactome	REACT_11046 REACT_18377 REACT_19327
EvolutionaryTrace	P18509
GeneWiki	Pituitary_adenylate_cyclase-activating_peptide
GenomeRNAi	116
NextBio	449
PRO	PR:P18509
Proteomes	UP000005640
Bgee	P18509
CleanEx	HS_ADCYAP1
ExpressionAtlas	P18509
Genevestigator	P18509
GO	GO:0005576 GO:0005615 GO:0043195 GO:0005184 GO:0051428 GO:0016521 GO:0005102 GO:0005057 GO:0007190 GO:0046034 GO:0001662 GO:0019933 GO:0007267 GO:0071385 GO:0007565 GO:0001821 GO:0002865 GO:0002878 GO:0045786 GO:0060253 GO:0010656 GO:0043267 GO:0034259 GO:0031175 GO:0007218 GO:0048011 GO:0001541 GO:0021983 GO:0010579 GO:0008284 GO:0007204 GO:0070374 GO:0060124 GO:0032755 GO:0010976 GO:0045860 GO:0032854 GO:0090274 GO:0051968 GO:0045944 GO:0045909 GO:0008277 GO:0070445 GO:0060078 GO:0032880 GO:0045471 GO:0042594 GO:0019233 GO:0007169
InterPro	IPR000532
Pfam	PF00123
PRINTS	PR00275
SMART	SM00070
PROSITE	PS00260

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	PMID:24696163^[1]	ECO:0000314			P	Figure 6	complete CACAO 9863
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:12239106^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70176	P	Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13589	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13589	P	Seeded From UniProt	complete
involved_in	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	PMID:24696163^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:9603988^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	PMID:9603988^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:9603988^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:7680413^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02643	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:17470806^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P41586	F	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:11175907^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019933	cAMP-mediated signaling	PMID:23800469^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:11175907^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:23800469^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70176	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000130195 UniProtKB:P18509	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 UniProtKB:P41534	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 UniProtKB:P41534	C	Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105094 PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:P41535 UniProtKB:Q29W19	P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P	Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105094 PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:P41535 UniProtKB:Q29W19	F	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002598721 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105094 MGI:MGI:95709 MGI:MGI:98933 PANTHER:PTN000130195 RGD:2037 RGD:61883 RGD:621647 UniProtKB:P01282 UniProtKB:P01284 UniProtKB:P01286 UniProtKB:P18509 UniProtKB:P41535 UniProtKB:P48143 UniProtKB:P81401 UniProtKB:Q29W19	P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000130195 RGD:2037 UniProtKB:P18509 UniProtKB:Q29W19	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016521	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016521	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016521	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016521	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016521	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	P	Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	P	Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	P	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	P	Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	F	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70176 ensembl:ENSMUSP00000067057	P	Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0090274	positive regulation of somatostatin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0070445	regulation of oligodendrocyte progenitor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0060253	negative regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0046034	ATP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0043950	positive regulation of cAMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0043267	negative regulation of potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	C	Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
enables	GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	F	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0019933	cAMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	F	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0010656	negative regulation of muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	C	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	F	Seeded From UniProt	complete
involved_in	GO:0002878	negative regulation of acute inflammatory response to non-antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0001821	histamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13589 ensembl:ENSRNOP00000070007	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000532	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000532	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	P	Seeded From UniProt	complete
enables	GO:0016521	pituitary adenylate cyclase activating polypeptide activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	F	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	P	Seeded From UniProt	complete
enables	GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039080	F	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:10698193^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:2302217^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007190	activation of adenylate cyclase activity	PMID:1730060^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:2302217^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-744887 Reactome:R-HSA-744886 Reactome:R-HSA-420131 Reactome:R-HSA-379044	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Rozzi, SJ et al. (2014) PACAP27 is protective against tat-induced neurotoxicity. J. Mol. Neurosci. 54 485-93 PubMed GONUTS page
↑ Gray, SL et al. (2002) Temperature-sensitive phenotype in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology 143 3946-54 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Yajima, Y et al. (1998) VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells. J. Biochem. 123 1024-30 PubMed GONUTS page
↑ Gaylinn, BD et al. (1993) Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Mol. Endocrinol. 7 77-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Emery, AC et al. (2013) Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Sci Signal 6 ra51 PubMed GONUTS page
↑ Sun, C et al. (2007) Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc. Natl. Acad. Sci. U.S.A. 104 7875-80 PubMed GONUTS page
↑ ^7.0 ^7.1 Inooka, H et al. (2001) Conformation of a peptide ligand bound to its G-protein coupled receptor. Nat. Struct. Biol. 8 161-5 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Scaldaferri, ML et al. (2000) Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. Endocrinology 141 1158-67 PubMed GONUTS page
↑ ^10.0 ^10.1 Kimura, C et al. (1990) A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem. Biophys. Res. Commun. 166 81-9 PubMed GONUTS page
↑ Hosoya, M et al. (1992) Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. Biochim. Biophys. Acta 1129 199-206 PubMed GONUTS page

[PMID:24696163-1] 1.0 ^1.1 Rozzi, SJ et al. (2014) PACAP27 is protective against tat-induced neurotoxicity. J. Mol. Neurosci. 54 485-93 PubMed GONUTS page

[PMID:12239106-2] Gray, SL et al. (2002) Temperature-sensitive phenotype in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology 143 3946-54 PubMed GONUTS page

[PMID:9603988-3] 3.0 ^3.1 ^3.2 Yajima, Y et al. (1998) VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells. J. Biochem. 123 1024-30 PubMed GONUTS page

[PMID:7680413-4] Gaylinn, BD et al. (1993) Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Mol. Endocrinol. 7 77-84 PubMed GONUTS page

[PMID:23800469-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Emery, AC et al. (2013) Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Sci Signal 6 ra51 PubMed GONUTS page

[PMID:17470806-6] Sun, C et al. (2007) Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc. Natl. Acad. Sci. U.S.A. 104 7875-80 PubMed GONUTS page

[PMID:11175907-7] 7.0 ^7.1 Inooka, H et al. (2001) Conformation of a peptide ligand bound to its G-protein coupled receptor. Nat. Struct. Biol. 8 161-5 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10698193-9] Scaldaferri, ML et al. (2000) Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. Endocrinology 141 1158-67 PubMed GONUTS page

[PMID:2302217-10] 10.0 ^10.1 Kimura, C et al. (1990) A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem. Biophys. Res. Commun. 166 81-9 PubMed GONUTS page

[PMID:1730060-11] Hosoya, M et al. (1992) Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. Biochim. Biophys. Acta 1129 199-206 PubMed GONUTS page

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