HUMAN:OSMR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) OSMR (synonyms: OSMRB)
Protein Name(s) Oncostatin-M-specific receptor subunit beta

Interleukin-31 receptor subunit beta IL-31 receptor subunit beta IL-31R subunit beta IL-31R-beta IL-31RB

External Links
UniProt Q99650
EMBL U60805
BC010943
BC063468
BC125209
BC125210
CCDS CCDS3928.1
CCDS54847.1
RefSeq NP_001161827.1
NP_003990.1
UniGene Hs.120658
Hs.658389
ProteinModelPortal Q99650
SMR Q99650
BioGrid 114617
IntAct Q99650
MINT MINT-4537651
STRING 9606.ENSP00000274276
PhosphoSite Q99650
DMDM 74724833
MaxQB Q99650
PaxDb Q99650
PRIDE Q99650
Ensembl ENST00000274276
ENST00000502536
GeneID 9180
KEGG hsa:9180
UCSC uc003jlm.2
uc003jln.2
CTD 9180
GeneCards GC05P038845
HGNC HGNC:8507
HPA HPA017278
MIM 105250
601743
neXtProt NX_Q99650
Orphanet 353220
PharmGKB PA32837
eggNOG NOG43445
GeneTree ENSGT00550000074436
HOGENOM HOG000115294
HOVERGEN HBG082088
InParanoid Q99650
KO K05057
OMA YHQELKM
OrthoDB EOG7V49XP
PhylomeDB Q99650
TreeFam TF338122
SignaLink Q99650
ChiTaRS OSMR
GeneWiki Oncostatin_M_receptor
GenomeRNAi 9180
NextBio 34417
PRO PR:Q99650
Proteomes UP000005640
Bgee Q99650
CleanEx HS_OSMR
ExpressionAtlas Q99650
Genevestigator Q99650
GO GO:0005900
GO:0019838
GO:0004924
GO:0038165
GO:0002675
GO:0008284
GO:0034097
Gene3D 2.60.40.10
InterPro IPR003961
IPR003529
IPR013783
Pfam PF00041
SMART SM00060
SUPFAM SSF49265
PROSITE PS50853
PS01353

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016324

apical plasma membrane

PMID:21912637[1]

ECO:0000314

C

Figure 5 - OsMRβ normally in the apical membrane

complete
CACAO 7575

part_of

GO:0016324

apical plasma membrane

PMID:21912637[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0038165

oncostatin-M-mediated signaling pathway

PMID:8999038[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

PMID:8999038[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019838

growth factor binding

PMID:8999038[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P13725

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:8999038[2]

ECO:0000316

genetic interaction evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

part_of

GO:0005900

oncostatin-M receptor complex

PMID:8999038[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0004924

oncostatin-M receptor activity

PMID:8999038[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002675

positive regulation of acute inflammatory response

PMID:8999038[2]

ECO:0000305

curator inference used in manual assertion

GO:0034097

P

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002745476
UniProtKB:Q14213
UniProtKB:Q9HC73

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002745476
UniProtKB:P10912
UniProtKB:P42702
UniProtKB:P48357
UniProtKB:Q5VWK5

C

Seeded From UniProt

complete

enables

GO:0019955

cytokine binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104579
MGI:MGI:1330819
MGI:MGI:2180511
PANTHER:PTN002745476
RGD:1303100
RGD:621431
UniProtKB:O75462
UniProtKB:P26992

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104579
MGI:MGI:1270861
MGI:MGI:1330819
MGI:MGI:1889506
MGI:MGI:2180511
MGI:MGI:96551
MGI:MGI:96560
PANTHER:PTN002745476

C

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96788
PANTHER:PTN002745510
UniProtKB:P42702
UniProtKB:Q99650

P

Seeded From UniProt

complete

part_of

GO:0005900

oncostatin-M receptor complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002507073
UniProtKB:Q99650

C

Seeded From UniProt

complete

contributes_to

GO:0004924

oncostatin-M receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330819
PANTHER:PTN002745510
UniProtKB:P42702
UniProtKB:Q99650

F

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003529

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003529

C

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6783589

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6784204
Reactome:R-HSA-6783552
Reactome:R-HSA-6783524
Reactome:R-HSA-448660

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Li, R et al. (2011) CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE 6 e23148 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Mosley, B et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271 32635-43 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page