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HUMAN:OFUT2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | POFUT2 (synonyms: C21orf80, FUT13, KIAA0958) | |
| Protein Name(s) | GDP-fucose protein O-fucosyltransferase 2
Peptide-O-fucosyltransferase 2 O-FucT-2 | |
| External Links | ||
| UniProt | Q9Y2G5 | |
| EMBL | AJ302080 AJ302079 AY066015 AJ575591 AB023175 AL110285 AL163301 BC011044 BC064623 | |
| CCDS | CCDS13719.1 CCDS13721.1 | |
| RefSeq | NP_056042.1 NP_598368.2 | |
| UniGene | Hs.592164 | |
| PDB | 4AP5 4AP6 | |
| PDBsum | 4AP5 4AP6 | |
| ProteinModelPortal | Q9Y2G5 | |
| SMR | Q9Y2G5 | |
| BioGrid | 116876 | |
| IntAct | Q9Y2G5 | |
| STRING | 9606.ENSP00000339613 | |
| CAZy | GT68 | |
| iPTMnet | Q9Y2G5 | |
| PhosphoSite | Q9Y2G5 | |
| BioMuta | POFUT2 | |
| DMDM | 59803123 | |
| EPD | Q9Y2G5 | |
| MaxQB | Q9Y2G5 | |
| PaxDb | Q9Y2G5 | |
| PRIDE | Q9Y2G5 | |
| DNASU | 23275 | |
| Ensembl | ENST00000331343 ENST00000334538 ENST00000349485 | |
| GeneID | 23275 | |
| KEGG | hsa:23275 | |
| UCSC | uc002zhb.4 | |
| CTD | 23275 | |
| GeneCards | POFUT2 | |
| HGNC | HGNC:14683 | |
| HPA | HPA044297 | |
| MIM | 610249 | |
| neXtProt | NX_Q9Y2G5 | |
| PharmGKB | PA25867 | |
| eggNOG | ENOG410IFPR ENOG410Y78N | |
| GeneTree | ENSGT00390000007989 | |
| HOVERGEN | HBG053367 | |
| InParanoid | Q9Y2G5 | |
| KO | K03691 | |
| OMA | CSHARFF | |
| OrthoDB | EOG76T9S1 | |
| PhylomeDB | Q9Y2G5 | |
| TreeFam | TF314337 | |
| BRENDA | 2.4.1.221 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-5173214 R-HSA-5173214] | |
| UniPathway | UPA00378 | |
| GenomeRNAi | 23275 | |
| PRO | PR:Q9Y2G5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y2G5 | |
| CleanEx | HS_POFUT2 | |
| ExpressionAtlas | Q9Y2G5 | |
| Genevisible | Q9Y2G5 | |
| GO | GO:0005789 GO:0005794 GO:0046922 GO:0006004 GO:0001707 GO:0036066 GO:0010717 GO:0010468 GO:0051046 | |
| InterPro | IPR019378 | |
| Pfam | PF10250 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1990773 |
matrix metallopeptidase secretion |
ECO:0000018 |
P |
Fig. 1 A and B show that POFUT2 is required for secretion of ADAMTS13, ADAMTSL1 and 2, and TSP1 targets in Human cells. |
complete | |||||
| GO:1903334 |
positive regulation of protein folding |
ECO:0000315 |
P |
Figure 5 shows that O-fucosylation by POFUT 2 increases the rate of TSR domain folding. TSR is a domain found in ADAMTS proteins. |
complete | |||||
| GO:0036066 |
protein O-linked fucosylation |
ECO:0000018 |
P |
Fig. 2A shows that O-fucosylation (identified by the use of 6-alkynylfucose) by POFUT2 occurs in the ER of human cells. EndoH digests only immature/incompletely-glycosylated proteins that are found only in the ER. |
complete | |||||
| GO:0033577 |
protein glycosylation in endoplasmic reticulum |
ECO:0000279 |
P |
Fig. 2A shows that O-fucosylation (identified by the use of 6-alkynylfucose) by POFUT2 occurs in the ER of human cells. EndoH digests only immature/incompletely-glycosylated proteins that are found only in the ER. |
complete | |||||
| GO:0046922 |
peptide-O-fucosyltransferase activity |
ECO:0000018 |
F |
Fig. 2A shows that O-fucosylation (identified by the use of 6-alkynylfucose) by POFUT2 occurs in the ER of human cells. EndoH digests only immature/incompletely-glycosylated proteins that are found only in the ER. |
complete | |||||
|
involved_in |
GO:0051046 |
regulation of secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046922 |
peptide-O-fucosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036066 |
protein O-linked fucosylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046922 |
peptide-O-fucosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0027791 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036065 |
fucosylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VHI3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010717 |
regulation of epithelial to mesenchymal transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VHI3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VHI3 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008417 |
fucosyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VHI3 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001707 |
mesoderm formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VHI3 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046922 |
peptide-O-fucosyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046922 |
peptide-O-fucosyltransferase activity |
Reactome:R-HSA-5173192 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036066 |
protein O-linked fucosylation |
Reactome:R-HSA-5173214 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-5173192 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006004 |
fucose metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Vasudevan, D et al. (2015) Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism. Curr. Biol. 25 286-95 PubMed GONUTS page
- ↑ Ricketts, LM et al. (2007) O-fucosylation is required for ADAMTS13 secretion. J. Biol. Chem. 282 17014-23 PubMed GONUTS page
- ↑ 3.0 3.1 Chen, CI et al. (2012) Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation. EMBO J. 31 3183-97 PubMed GONUTS page
- ↑ Menzel, O et al. (2004) The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development. Genomics 84 320-30 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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