HUMAN:OCLN

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	OCLN
Protein Name(s)	Occludin
External Links
UniProt	Q16625
EMBL	U49184 U53823 FJ786083 FJ786084 AF400630 AF400623 AF400624 AF400625 AF400626 AF400627 AF400628 AF400629 GQ225096 GQ225097 GQ225098 GQ402517 AB451306 AB451437 AC145146 AC147575 BC029886 BK001650
CCDS	CCDS4006.1 CCDS54864.1
PIR	G02533
RefSeq	NP_001192183.1 NP_001192184.1 NP_002529.1 XP_006714575.1
UniGene	Hs.592605
PDB	1WPA 1XAW 3G7C
PDBsum	1WPA 1XAW 3G7C
ProteinModelPortal	Q16625
SMR	Q16625
BioGrid	111004
DIP	DIP-42791N
IntAct	Q16625
MINT	MINT-5006137
STRING	9606.ENSP00000347379
TCDB	9.B.41.1.1
PhosphoSite	Q16625
DMDM	3914196
MaxQB	Q16625
PaxDb	Q16625
PRIDE	Q16625
Ensembl	ENST00000355237 ENST00000396442 ENST00000538151
GeneID	100506658
KEGG	hsa:100506658
UCSC	uc003jwu.3 uc021xzt.1
CTD	100506658
GeneCards	GC05P068788
HGNC	HGNC:8104
HPA	CAB013075 HPA005933
MIM	251290 602876
neXtProt	NX_Q16625
Orphanet	1229
PharmGKB	PA31893
eggNOG	NOG71745
GeneTree	ENSGT00730000110989
HOGENOM	HOG000233490
HOVERGEN	HBG004523
InParanoid	Q16625
KO	K06088
OMA	YAPSNDV
OrthoDB	EOG7PS1F4
PhylomeDB	Q16625
TreeFam	TF326161
Reactome	REACT_13579
EvolutionaryTrace	Q16625
GeneWiki	Occludin
GenomeRNAi	100506658
NextBio	34054345
PMAP-CutDB	Q16625
PRO	PR:Q16625
Proteomes	UP000005640
Bgee	Q16625
CleanEx	HS_OCLN
Genevestigator	Q16625
GO	GO:0016324 GO:0016327 GO:0030054 GO:0005911 GO:0031410 GO:0005829 GO:0030139 GO:0016021 GO:0005886 GO:0005923 GO:0019904 GO:0005198 GO:0008119 GO:0006915 GO:0045216 GO:0006921 GO:0006461 GO:0046498 GO:0046500 GO:0070830
InterPro	IPR008253 IPR020846 IPR002958 IPR010844
PANTHER	PTHR23288:SF4
Pfam	PF01284 PF07303
PIRSF	PIRSF005993
PRINTS	PR01258
SUPFAM	SSF103473
PROSITE	PS51225

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005923	tight junction	PMID:23555257^[1]	ECO:0000314			C		Figure 2 shows that occludin directed blocking antibodies inhibits hepatitis c infection	complete CACAO 8004
part_of	GO:0005911	cell-cell junction	PMID:23288152^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	PMID:20164257^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:20164257^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:20164257^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07157	F		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:20028514^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000575)\|part_of:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:19332538^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	PMID:20164257^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	PMID:24567356^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:20164257^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61146 ensembl:ENSMUSP00000065284	C		Seeded From UniProt	complete
part_of	GO:0016327	apicolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61146 ensembl:ENSMUSP00000065284	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61146 ensembl:ENSMUSP00000065284	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61146 ensembl:ENSMUSP00000065284	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61146 ensembl:ENSMUSP00000065284	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61146 ensembl:ENSMUSP00000065284	C		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P6T5 ensembl:ENSRNOP00000024674	P		Seeded From UniProt	complete
involved_in	GO:0070673	response to interleukin-18	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P6T5 ensembl:ENSRNOP00000024674	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P6T5 ensembl:ENSRNOP00000024674	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P6T5 ensembl:ENSRNOP00000024674	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002958	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008253	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002958	C		Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002958	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:10749869^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8601611^[8] Reactome:R-HSA-351876	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	Reactome:R-HSA-8935964	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	Reactome:R-HSA-8935988	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0796 UniProtKB-SubCell:SL-0265	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sourisseau, M et al. (2013) Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies. PLoS Pathog. 9 e1003244 PubMed GONUTS page
↑ Kluger, MS et al. (2013) Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33 489-500 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Raleigh, DR et al. (2010) Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol. Biol. Cell 21 1200-13 PubMed GONUTS page
↑ Steed, E et al. (2009) Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. BMC Cell Biol. 10 95 PubMed GONUTS page
↑ Sallee, JL & Burridge, K (2009) Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J. Biol. Chem. 284 14997-5006 PubMed GONUTS page
↑ Steed, E et al. (2014) MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. J. Cell Biol. 204 821-38 PubMed GONUTS page
↑ Singh, U et al. (2000) CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin. J. Biol. Chem. 275 18407-17 PubMed GONUTS page
↑ Ando-Akatsuka, Y et al. (1996) Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J. Cell Biol. 133 43-7 PubMed GONUTS page

[PMID:23555257-1] Sourisseau, M et al. (2013) Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies. PLoS Pathog. 9 e1003244 PubMed GONUTS page

[PMID:23288152-2] Kluger, MS et al. (2013) Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33 489-500 PubMed GONUTS page

[PMID:20164257-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Raleigh, DR et al. (2010) Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol. Biol. Cell 21 1200-13 PubMed GONUTS page

[PMID:20028514-4] Steed, E et al. (2009) Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. BMC Cell Biol. 10 95 PubMed GONUTS page

[PMID:19332538-5] Sallee, JL & Burridge, K (2009) Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J. Biol. Chem. 284 14997-5006 PubMed GONUTS page

[PMID:24567356-6] Steed, E et al. (2014) MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. J. Cell Biol. 204 821-38 PubMed GONUTS page

[PMID:10749869-7] Singh, U et al. (2000) CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin. J. Biol. Chem. 275 18407-17 PubMed GONUTS page

[PMID:8601611-8] Ando-Akatsuka, Y et al. (1996) Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J. Cell Biol. 133 43-7 PubMed GONUTS page

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HUMAN:OCLN

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