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HUMAN:OAT
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | OAT | |
Protein Name(s) | Ornithine aminotransferase, mitochondrial
Ornithine delta-aminotransferase Ornithine--oxo-acid aminotransferase Ornithine aminotransferase, hepatic form Ornithine aminotransferase, renal form | |
External Links | ||
UniProt | P04181 | |
EMBL | M12267 M14963 Y07511 M23204 M23205 M88760 M29927 M29919 M29920 M29921 M29922 M29923 M29924 M29925 M29926 AK296032 AK312561 AK315947 CR457045 CR749808 AL445237 CH471066 CH471066 BC000964 BC016928 S66418 S66421 | |
CCDS | CCDS53586.1 CCDS7639.1 | |
PIR | A30806 I55360 | |
RefSeq | NP_000265.1 NP_001165285.1 XP_006717934.1 | |
UniGene | Hs.523332 | |
PDB | 1GBN 1OAT 2BYJ 2BYL 2CAN 2OAT | |
PDBsum | 1GBN 1OAT 2BYJ 2BYL 2CAN 2OAT | |
ProteinModelPortal | P04181 | |
SMR | P04181 | |
BioGrid | 110996 | |
IntAct | P04181 | |
MINT | MINT-1387274 | |
STRING | 9606.ENSP00000357838 | |
ChEMBL | CHEMBL5954 | |
DrugBank | DB00129 | |
PhosphoSite | P04181 | |
DMDM | 129018 | |
REPRODUCTION-2DPAGE | IPI00022334 | |
MaxQB | P04181 | |
PaxDb | P04181 | |
PeptideAtlas | P04181 | |
PRIDE | P04181 | |
DNASU | 4942 | |
Ensembl | ENST00000368845 ENST00000539214 | |
GeneID | 4942 | |
KEGG | hsa:4942 | |
UCSC | uc001lhp.3 | |
CTD | 4942 | |
GeneCards | GC10M126075 | |
HGNC | HGNC:8091 | |
HPA | CAB033576 HPA040098 | |
MIM | 258870 613349 | |
neXtProt | NX_P04181 | |
Orphanet | 414 | |
PharmGKB | PA31880 | |
eggNOG | COG4992 | |
GeneTree | ENSGT00630000089895 | |
HOGENOM | HOG000020206 | |
HOVERGEN | HBG000434 | |
InParanoid | P04181 | |
KO | K00819 | |
OMA | THDHTIR | |
OrthoDB | EOG7SJD4P | |
PhylomeDB | P04181 | |
TreeFam | TF105720 | |
BioCyc | MetaCyc:HS00832-MONOMER | |
Reactome | REACT_238 | |
SABIO-RK | P04181 | |
UniPathway | UPA00098 | |
EvolutionaryTrace | P04181 | |
GenomeRNAi | 4942 | |
NextBio | 19041 | |
PRO | PR:P04181 | |
Proteomes | UP000005640 | |
Bgee | P04181 | |
CleanEx | HS_OAT | |
Genevestigator | P04181 | |
GO | GO:0005759 GO:0005739 GO:0004587 GO:0030170 GO:0008652 GO:0034641 GO:0055129 GO:0034214 GO:0044281 GO:0007601 | |
Gene3D | 3.40.640.10 3.90.1150.10 | |
InterPro | IPR005814 IPR010164 IPR015424 IPR015421 IPR015422 | |
PANTHER | PTHR11986 PTHR11986:SF18 | |
Pfam | PF00202 | |
PIRSF | PIRSF000521 | |
SUPFAM | SSF53383 | |
TIGRFAMs | TIGR01885 | |
PROSITE | PS00600 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034214 |
protein hexamerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030170 |
pyridoxal phosphate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG12718 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019544 |
arginine catabolic process to glutamate |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000241155 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010121 |
arginine catabolic process to proline via ornithine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000241155 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000241155 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004587 |
ornithine-oxo-acid transaminase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000241155 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04182 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P04182 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004587 |
ornithine-oxo-acid transaminase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008483 |
transaminase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030170 |
pyridoxal phosphate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004587 |
ornithine-oxo-acid transaminase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007601 |
visual perception |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004587 |
ornithine-oxo-acid transaminase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008652 |
cellular amino acid biosynthetic process |
Reactome:R-HSA-70614 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-70666 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008483 |
transaminase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055129 |
L-proline biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00098 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Inana, G et al. (1986) Molecular cloning of human ornithine aminotransferase mRNA. Proc. Natl. Acad. Sci. U.S.A. 83 1203-7 PubMed GONUTS page
- ↑ Shen, BW et al. (1998) Crystal structure of human recombinant ornithine aminotransferase. J. Mol. Biol. 277 81-102 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Inana, G et al. (1989) Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy. J. Biol. Chem. 264 17432-6 PubMed GONUTS page