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HUMAN:OAT

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) OAT
Protein Name(s) Ornithine aminotransferase, mitochondrial

Ornithine delta-aminotransferase Ornithine--oxo-acid aminotransferase Ornithine aminotransferase, hepatic form Ornithine aminotransferase, renal form

External Links
UniProt P04181
EMBL M12267
M14963
Y07511
M23204
M23205
M88760
M29927
M29919
M29920
M29921
M29922
M29923
M29924
M29925
M29926
AK296032
AK312561
AK315947
CR457045
CR749808
AL445237
CH471066
CH471066
BC000964
BC016928
S66418
S66421
CCDS CCDS53586.1
CCDS7639.1
PIR A30806
I55360
RefSeq NP_000265.1
NP_001165285.1
XP_006717934.1
UniGene Hs.523332
PDB 1GBN
1OAT
2BYJ
2BYL
2CAN
2OAT
PDBsum 1GBN
1OAT
2BYJ
2BYL
2CAN
2OAT
ProteinModelPortal P04181
SMR P04181
BioGrid 110996
IntAct P04181
MINT MINT-1387274
STRING 9606.ENSP00000357838
ChEMBL CHEMBL5954
DrugBank DB00129
PhosphoSite P04181
DMDM 129018
REPRODUCTION-2DPAGE IPI00022334
MaxQB P04181
PaxDb P04181
PeptideAtlas P04181
PRIDE P04181
DNASU 4942
Ensembl ENST00000368845
ENST00000539214
GeneID 4942
KEGG hsa:4942
UCSC uc001lhp.3
CTD 4942
GeneCards GC10M126075
HGNC HGNC:8091
HPA CAB033576
HPA040098
MIM 258870
613349
neXtProt NX_P04181
Orphanet 414
PharmGKB PA31880
eggNOG COG4992
GeneTree ENSGT00630000089895
HOGENOM HOG000020206
HOVERGEN HBG000434
InParanoid P04181
KO K00819
OMA THDHTIR
OrthoDB EOG7SJD4P
PhylomeDB P04181
TreeFam TF105720
BioCyc MetaCyc:HS00832-MONOMER
Reactome REACT_238
SABIO-RK P04181
UniPathway UPA00098
EvolutionaryTrace P04181
GenomeRNAi 4942
NextBio 19041
PRO PR:P04181
Proteomes UP000005640
Bgee P04181
CleanEx HS_OAT
Genevestigator P04181
GO GO:0005759
GO:0005739
GO:0004587
GO:0030170
GO:0008652
GO:0034641
GO:0055129
GO:0034214
GO:0044281
GO:0007601
Gene3D 3.40.640.10
3.90.1150.10
InterPro IPR005814
IPR010164
IPR015424
IPR015421
IPR015422
PANTHER PTHR11986
PTHR11986:SF18
Pfam PF00202
PIRSF PIRSF000521
SUPFAM SSF53383
TIGRFAMs TIGR01885
PROSITE PS00600

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005759

mitochondrial matrix

PMID:3456579[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034214

protein hexamerization

PMID:9514741[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030170

pyridoxal phosphate binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12718
PANTHER:PTN000241033

F

Seeded From UniProt

complete

involved_in

GO:0019544

arginine catabolic process to glutamate

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000241155
TAIR:locus:2161398

P

Seeded From UniProt

complete

involved_in

GO:0010121

arginine catabolic process to proline via ornithine

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000241155
PomBase:SPBC21C3.08c

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000241155
RGD:621724

C

Seeded From UniProt

complete

enables

GO:0004587

ornithine-oxo-acid transaminase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000241155
SGD:S000004430
TAIR:locus:2161398
UniProtKB:P04181
UniProtKB:Q92413

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04182
ensembl:ENSRNOP00000022628

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04182
ensembl:ENSRNOP00000022628

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015421
InterPro:IPR015422

F

Seeded From UniProt

complete

enables

GO:0004587

ornithine-oxo-acid transaminase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010164
InterPro:IPR034758

F

Seeded From UniProt

complete

enables

GO:0008483

transaminase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005814

F

Seeded From UniProt

complete

enables

GO:0030170

pyridoxal phosphate binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005814

F

Seeded From UniProt

complete

enables

GO:0004587

ornithine-oxo-acid transaminase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.6.1.13

F

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

PMID:2793865[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:2793865[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004587

ornithine-oxo-acid transaminase activity

PMID:3456579[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

Reactome:R-HSA-70614

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-70666
Reactome:R-HSA-70654

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0008483

transaminase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0032

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

involved_in

GO:0055129

L-proline biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00098

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Inana, G et al. (1986) Molecular cloning of human ornithine aminotransferase mRNA. Proc. Natl. Acad. Sci. U.S.A. 83 1203-7 PubMed GONUTS page
  2. Shen, BW et al. (1998) Crystal structure of human recombinant ornithine aminotransferase. J. Mol. Biol. 277 81-102 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 Inana, G et al. (1989) Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy. J. Biol. Chem. 264 17432-6 PubMed GONUTS page