HUMAN:NTRK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NTRK2 (synonyms: TRKB)
Protein Name(s)	BDNF/NT-3 growth factors receptor GP145-TrkB Trk-B Neurotrophic tyrosine kinase receptor type 2 TrkB tyrosine kinase Tropomyosin-related kinase B
External Links
UniProt	Q16620
EMBL	U12140 S76473 S76474 X75958 AF410899 AF410900 AF410901 AF508964 AB209118 AK294285 AL445532 AL390777 AL596132 AL390777 AL596132 AL390777 AL596132 AL390777 AL445532 AL596132 AL596132 AL390777 AL596132 AL390777 AL596132 AL390777 AL445532 CH471089 BC031835
CCDS	CCDS35050.1 CCDS35051.1 CCDS35052.1 CCDS35053.1 CCDS6671.1
PIR	A56853 I73631
RefSeq	NP_001007098.1 NP_001018074.1 NP_001018075.1 NP_001018076.1 NP_006171.2 XP_005252058.1 XP_005252060.1 XP_005252061.1 XP_005252063.1 XP_005252064.1
UniGene	Hs.494312 Hs.712776
PDB	1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5
PDBsum	1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5
ProteinModelPortal	Q16620
SMR	Q16620
BioGrid	110970
DIP	DIP-5720N
IntAct	Q16620
MINT	MINT-156841
STRING	9606.ENSP00000277120
BindingDB	Q16620
ChEMBL	CHEMBL4898
DrugBank	DB00321
GuidetoPHARMACOLOGY	1818
MEROPS	I43.001
PhosphoSite	Q16620
DMDM	2497560
PaxDb	Q16620
PRIDE	Q16620
DNASU	4915
Ensembl	ENST00000277120 ENST00000304053 ENST00000323115 ENST00000359847 ENST00000376208 ENST00000376213 ENST00000376214 ENST00000395882
GeneID	4915
KEGG	hsa:4915
UCSC	uc004any.1 uc004anz.1 uc004aoa.1 uc011lsz.2 uc011lta.2 uc011ltb.1
CTD	4915
GeneCards	GC09P087283
HGNC	HGNC:8032
HPA	CAB010346 HPA007637
MIM	600456 613886
neXtProt	NX_Q16620
Orphanet	251612
PharmGKB	PA31818
eggNOG	COG0515
GeneTree	ENSGT00760000118818
HOGENOM	HOG000264255
HOVERGEN	HBG056735
InParanoid	Q16620
KO	K04360
OMA	CEIMWIK
OrthoDB	EOG7QG43C
PhylomeDB	Q16620
TreeFam	TF106465
BRENDA	2.7.10.1
Reactome	REACT_11046
SignaLink	Q16620
ChiTaRS	NTRK2
EvolutionaryTrace	Q16620
GeneWiki	TrkB_receptor
GenomeRNAi	4915
NextBio	18915
PRO	PR:Q16620
Proteomes	UP000005640
Bgee	Q16620
CleanEx	HS_NTRK2
ExpressionAtlas	Q16620
Genevestigator	Q16620
GO	GO:0009986 GO:0005829 GO:0043197 GO:0010008 GO:0060076 GO:0030426 GO:0005887 GO:0097481 GO:0043204 GO:0045211 GO:0048786 GO:0043235 GO:0005791 GO:0043195 GO:0005524 GO:0048403 GO:0060175 GO:0043121 GO:0042803 GO:0007190 GO:0007568 GO:0031547 GO:0035584 GO:1990090 GO:0071356 GO:0021954 GO:0021987 GO:0007623 GO:0007631 GO:0014047 GO:0006954 GO:0007612 GO:0007616 GO:0060291 GO:0042490 GO:2000811 GO:0043524 GO:0007528 GO:0030182 GO:0001764 GO:0048011 GO:0048709 GO:0048935 GO:0050772 GO:0008284 GO:0010628 GO:0043410 GO:0010976 GO:0014068 GO:0051968 GO:0046777 GO:0050773 GO:0046928 GO:0051896 GO:0032314 GO:0010996 GO:0009416 GO:0046548 GO:0007169 GO:0001570
Gene3D	2.60.40.10
InterPro	IPR000483 IPR007110 IPR013783 IPR013098 IPR003598 IPR011009 IPR001611 IPR000372 IPR000719 IPR017441 IPR001245 IPR020455 IPR008266 IPR020635 IPR020777 IPR002011
Pfam	PF07679 PF13855 PF01462 PF07714
PRINTS	PR01939 PR01941 PR00109
SMART	SM00408 SM00082 SM00013 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	C		Seeded From UniProt	complete
enables	GO:0060175	brain-derived neurotrophic factor-activated receptor activity	PMID:15494731^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	P		Seeded From UniProt	complete
enables	GO:0048403	brain-derived neurotrophic factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	F		Seeded From UniProt	complete
enables	GO:0048403	brain-derived neurotrophic factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	P		Seeded From UniProt	complete
enables	GO:0043121	neurotrophin binding	PMID:11738045^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043121	neurotrophin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	F		Seeded From UniProt	complete
enables	GO:0043121	neurotrophin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	F		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	PMID:15494731^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:0021954	central nervous system neuron development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63604	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15494731^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
involved_in	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699897 RGD:3213	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 PANTHER:PTN001230900 RGD:3213 RGD:620144 UniProtKB:P04629	P		Seeded From UniProt	complete
involved_in	GO:0099551	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN000699897	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 UniProtKB:P04629	P		Seeded From UniProt	complete
enables	GO:0060175	brain-derived neurotrophic factor-activated receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN000699897 RGD:3213 UniProtKB:Q16620	F		Seeded From UniProt	complete
involved_in	GO:0051896	regulation of protein kinase B signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN000698829	P		Seeded From UniProt	complete
enables	GO:0048403	brain-derived neurotrophic factor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN000699897 RGD:3213	F		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699897 RGD:3213	C		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 RGD:3213 UniProtKB:Q16288	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 RGD:3213 UniProtKB:Q16288	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699897 RGD:3213	C		Seeded From UniProt	complete
enables	GO:0043121	neurotrophin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN001230900 RGD:3213 UniProtKB:Q16620	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 PANTHER:PTN001230900 RGD:3213 RGD:620144	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 PANTHER:PTN000699897 RGD:3213	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400475 RGD:3213	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97384 MGI:MGI:97385 PANTHER:PTN002400475 RGD:3213 RGD:3214 UniProtKB:Q91987	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97383 MGI:MGI:97384 MGI:MGI:97385 PANTHER:PTN002400475 RGD:3213 RGD:3214 RGD:620144 UniProtKB:P04629 UniProtKB:Q91987 ZFIN:ZDB-GENE-010126-3	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005030	neurotrophin receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001230900 RGD:3213 UniProtKB:Q16288	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0099551	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
enables	GO:0060175	brain-derived neurotrophic factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	F		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0051896	regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0048935	peripheral nervous system neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
enables	GO:0048403	brain-derived neurotrophic factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	F		Seeded From UniProt	complete
involved_in	GO:0046548	retinal rod cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	C		Seeded From UniProt	complete
enables	GO:0043121	neurotrophin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	F		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0042490	mechanoreceptor differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0022011	myelination in peripheral nervous system	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0021954	central nervous system neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0019227	neuronal action potential propagation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0019222	regulation of metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	C		Seeded From UniProt	complete
involved_in	GO:0014047	glutamate secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	C		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15209 ensembl:ENSMUSP00000078757	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR020455 InterPro:IPR020777	F		Seeded From UniProt	complete
enables	GO:0005030	neurotrophin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020455	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR002011 InterPro:IPR017441 InterPro:IPR020777	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020455 InterPro:IPR020777	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR002011 InterPro:IPR008266 InterPro:IPR020455 InterPro:IPR020635 InterPro:IPR020777	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR020455 InterPro:IPR020777	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19036963^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0014068) has_regulation_target:(PR:000029189)	Seeded From UniProt	complete
involved_in	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	PMID:19036963^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0048668) part_of:(UBERON:0000966)	Seeded From UniProt	complete
involved_in	GO:1903997	positive regulation of non-membrane spanning protein tyrosine kinase activity	Reactome:R-HSA-9032500	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	Reactome:R-HSA-9028731	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007202	activation of phospholipase C activity	Reactome:R-HSA-9026527	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9032798 Reactome:R-HSA-9032073 Reactome:R-HSA-9028730 Reactome:R-HSA-9026894	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-RNO-9613030	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-RNO-9613030	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yeo, GS et al. (2004) A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat. Neurosci. 7 1187-9 PubMed GONUTS page
↑ Banfield, MJ et al. (2001) Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure 9 1191-9 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 ^3.20 ^3.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ ^5.0 ^5.1 Marler, KJ et al. (2008) A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J. Neurosci. 28 12700-12 PubMed GONUTS page

[PMID:15494731-1] 1.0 ^1.1 ^1.2 Yeo, GS et al. (2004) A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat. Neurosci. 7 1187-9 PubMed GONUTS page

[PMID:11738045-2] Banfield, MJ et al. (2001) Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure 9 1191-9 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 ^3.20 ^3.21 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23382219-4] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:19036963-5] 5.0 ^5.1 Marler, KJ et al. (2008) A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J. Neurosci. 28 12700-12 PubMed GONUTS page

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HUMAN:NTRK2

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