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HUMAN:NSF

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NSF
Protein Name(s) Vesicle-fusing ATPase

N-ethylmaleimide-sensitive fusion protein NEM-sensitive fusion protein Vesicular-fusion protein NSF

External Links
UniProt P46459
EMBL U03985
AF135168
AF102846
AK290204
AK294001
AC004098
AC138645
AC138688
AC217769
AC217778
AC217780
BC030613
CCDS CCDS42354.1
PIR G01234
RefSeq NP_006169.2
UniGene Hs.431279
ProteinModelPortal P46459
SMR P46459
BioGrid 110960
DIP DIP-389N
IntAct P46459
MINT MINT-1369243
STRING 9606.ENSP00000381293
ChEMBL CHEMBL2311231
TCDB 1.F.1.1.1
PhosphoSite P46459
DMDM 257051048
UCD-2DPAGE P46459
MaxQB P46459
PaxDb P46459
PRIDE P46459
Ensembl ENST00000398238
ENST00000611398
ENST00000620290
GeneID 4905
KEGG hsa:4905
UCSC uc002iku.3
CTD 4905
GeneCards GC17P044668
H-InvDB HIX0013914
HIX0013915
HGNC HGNC:8016
HPA CAB009324
CAB013645
HPA003154
MIM 601633
neXtProt NX_P46459
PharmGKB PA31793
eggNOG COG0464
GeneTree ENSGT00530000064085
HOGENOM HOG000198544
HOVERGEN HBG000324
InParanoid P46459
KO K06027
OMA FKDKERS
OrthoDB EOG7P8P7F
PhylomeDB P46459
TreeFam TF300371
Reactome REACT_18422
ChiTaRS NSF
GeneWiki N-ethylmaleimide_sensitive_fusion_protein
GenomeRNAi 4905
NextBio 18875
PMAP-CutDB P46459
PRO PR:P46459
Proteomes UP000005640
UP000005640
Bgee P46459
CleanEx HS_NSF
ExpressionAtlas P46459
Genevestigator P46459
GO GO:0005737
GO:0005829
GO:0043198
GO:0070062
GO:0005795
GO:0005765
GO:0005886
GO:0014069
GO:0005524
GO:0016887
GO:0042623
GO:0046872
GO:0030165
GO:0032403
GO:0019901
GO:0017137
GO:0017075
GO:0006200
GO:0006887
GO:0045026
GO:0001921
GO:0006813
GO:0015031
GO:0017157
GO:0007268
GO:0016192
Gene3D 3.10.330.10
3.40.50.300
InterPro IPR003593
IPR009010
IPR003959
IPR003960
IPR004201
IPR029067
IPR003338
IPR027417
Pfam PF00004
PF02933
PF02359
SMART SM00382
SM01072
SM01073
SUPFAM SSF50692
SSF52540
SSF54585
PROSITE PS00674

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006886

intracellular protein transport

PMID:22045810[1]

ECO:0000315

P

Fig. 7BC

complete
CACAO 2694

GO:0045732

positive regulation of protein catabolic process

PMID:22045810[1]

ECO:0000315

P

Fig. 7

complete
CACAO 2695

enables

GO:0035255

ionotropic glutamate receptor binding

PMID:12130635[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P42262

F

part_of:(GO:2000008)

Seeded From UniProt

complete

enables

GO:0000149

SNARE binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18708

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18708

F

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18708

F

part_of:(GO:0035494)

Seeded From UniProt

complete

involved_in

GO:0035494

SNARE complex disassembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18708

P

has_direct_input:(GO:0070044)

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:22045810[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:22045810[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043198

dendritic shaft

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

C

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

C

Seeded From UniProt

complete

part_of

GO:0005795

Golgi stack

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

C

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

F

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

F

Seeded From UniProt

complete

involved_in

GO:0017157

regulation of exocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUL6

P

Seeded From UniProt

complete

enables

GO:0017075

syntaxin-1 binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P46460

F

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P46460

F

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:15613468[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030165

PDZ domain binding

PMID:15613468[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60896

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15613468[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

PMID:17897319[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001921

positive regulation of receptor recycling

PMID:15613468[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048211

Golgi vesicle docking

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554891
SGD:S000000284

P

Seeded From UniProt

complete

involved_in

GO:0043001

Golgi to plasma membrane protein transport

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554891
SGD:S000000284
UniProtKB:A0A1D8PFN6

P

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554891
RGD:621594
SGD:S000000284

F

Seeded From UniProt

complete

part_of

GO:0005795

Golgi stack

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000554891
RGD:621594

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048208

C

Seeded From UniProt

complete

enables

GO:0042623

ATPase activity, coupled

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P46460
ensembl:ENSMUSP00000099364

F

Seeded From UniProt

complete

enables

GO:0019905

syntaxin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P46460
ensembl:ENSMUSP00000099364

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P46460
ensembl:ENSMUSP00000099364

F

Seeded From UniProt

complete

enables

GO:0017075

syntaxin-1 binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P46460
ensembl:ENSMUSP00000099364

F

Seeded From UniProt

complete

involved_in

GO:0006813

potassium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P46460
ensembl:ENSMUSP00000099364

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003959
InterPro:IPR003960

F

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039812

F

Seeded From UniProt

complete

involved_in

GO:0035494

SNARE complex disassembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039812

P

Seeded From UniProt

complete

involved_in

GO:0045026

plasma membrane fusion

PMID:15613468[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006887

exocytosis

PMID:15613468[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048208

COPII vesicle coating

Reactome:R-HSA-204005

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

Reactome:R-HSA-416985

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006890

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reactome:R-HSA-6811434

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

Reactome:R-HSA-199977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8847638
Reactome:R-HSA-8847637
Reactome:R-HSA-6814684
Reactome:R-HSA-6814683
Reactome:R-HSA-6814678
Reactome:R-HSA-6814676
Reactome:R-HSA-6811425
Reactome:R-HSA-6811422
Reactome:R-HSA-6809015
Reactome:R-HSA-6809014
Reactome:R-HSA-5694425
Reactome:R-HSA-5694423
Reactome:R-HSA-416985

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Sangwan, V et al. (2011) Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J. Biol. Chem. 286 45000-13 PubMed GONUTS page
  2. ↑ Narisawa-Saito, M et al. (2002) Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons. J. Biol. Chem. 277 40901-10 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Bomberger, JM et al. (2005) Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. J. Biol. Chem. 280 9297-307 PubMed GONUTS page
  4. ↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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