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HUMAN:NRG3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NRG3
Protein Name(s) Pro-neuregulin-3, membrane-bound isoform

Pro-NRG3 Neuregulin-3 NRG-3

External Links
UniProt P56975
EMBL DQ857894
DQ001411
AL354749
AL096706
AL136085
AL391478
AL513204
AL589782
AL136085
AL096706
AL354749
AL391478
AL513204
AL589782
AL513204
AL096706
AL136085
AL354749
AL391478
AL589782
AL391478
AL096706
AL136085
AL354749
AL513204
AL589782
AL589782
AL096706
AL136085
AL354749
AL391478
AL513204
AL096706
AL136085
AL354749
AL391478
AL513204
AL589782
CCDS CCDS31233.1
CCDS53547.1
RefSeq NP_001010848.2
NP_001159445.1
XP_005269501.1
UniGene Hs.125119
ProteinModelPortal P56975
SMR P56975
STRING 9606.ENSP00000361214
PhosphoSite P56975
DMDM 9789758
PaxDb P56975
PRIDE P56975
Ensembl ENST00000372141
ENST00000372142
ENST00000404547
GeneID 10718
KEGG hsa:10718
UCSC uc001kco.2
uc001kcp.2
uc001kcr.2
CTD 10718
GeneCards GC10P083625
HGNC HGNC:7999
HPA HPA038206
MIM 605533
neXtProt NX_P56975
PharmGKB PA31778
eggNOG NOG40523
GeneTree ENSGT00760000119412
HOGENOM HOG000113852
HOVERGEN HBG006532
InParanoid P56975
KO K05457
OrthoDB EOG7SR4KZ
PhylomeDB P56975
TreeFam TF336537
Reactome REACT_115596
REACT_115755
REACT_115854
REACT_115961
REACT_115993
REACT_116005
REACT_116008
REACT_116022
REACT_147727
REACT_75829
SignaLink P56975
ChiTaRS NRG3
GeneWiki NRG3
GenomeRNAi 10718
NextBio 40693
PRO PR:P56975
Proteomes UP000005640
Bgee P56975
CleanEx HS_NRG3
ExpressionAtlas P56975
Genevestigator P56975
GO GO:0005576
GO:0005887
GO:0008083
GO:0030971
GO:0030297
GO:0007171
GO:0035556
GO:0060596
GO:0007389
GO:0001558
InterPro IPR000742
IPR013032
SMART SM00181
PROSITE PS00022
PS01186
PS50026

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0030971

receptor tyrosine kinase binding

PMID:9275162[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030297

transmembrane receptor protein tyrosine kinase activator activity

PMID:9275162[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:9275162[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9275162[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:9275162[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001558

regulation of cell growth

PMID:9275162[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:29114105[2]

ECO:0006063

over expression analysis evidence used in manual assertion

C

part_of:(UBERON:0001950)

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:29114105[2]

ECO:0006063

over expression analysis evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0001950)

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097165
PANTHER:PTN000873337

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000873337
RGD:621341
UniProtKB:Q02297

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000873337
UniProtKB:Q02297

F

Seeded From UniProt

complete

involved_in

GO:0007171

activation of transmembrane receptor protein tyrosine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030297

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:2001223

negative regulation of neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

P

Seeded From UniProt

complete

involved_in

GO:0060596

mammary placode formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

P

Seeded From UniProt

complete

enables

GO:0045499

chemorepellent activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

P

Seeded From UniProt

complete

involved_in

GO:0030879

mammary gland development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

P

Seeded From UniProt

complete

involved_in

GO:0021842

chemorepulsion involved in interneuron migration from the subpallium to the cortex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

P

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35181
ensembl:ENSMUSP00000136884

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040180

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040180

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Zhang, D et al. (1997) Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc. Natl. Acad. Sci. U.S.A. 94 9562-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 Zhou, L et al. (2018) Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition. Neuropsychopharmacology 43 1343-1354 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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