HUMAN:NRAM1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLC11A1 (synonyms: LSH, NRAMP, NRAMP1)
Protein Name(s)	Natural resistance-associated macrophage protein 1 NRAMP 1 Solute carrier family 11 member 1
External Links
UniProt	P49279
EMBL	L32185 L38593 L38592 AF229163 AC021016 CH471063 BC071165 D50402 D50403 D38171 X82015
CCDS	CCDS2415.1
PIR	I55679 JC4095
RefSeq	NP_000569.3 XP_005246850.1 XP_005246851.1 XP_006712772.1 XP_006712773.1
UniGene	Hs.591607
ProteinModelPortal	P49279
STRING	9606.ENSP00000233202
BindingDB	P49279
ChEMBL	CHEMBL2052040
TCDB	2.A.55.2.3
PhosphoSite	P49279
DMDM	1352521
PaxDb	P49279
PRIDE	P49279
Ensembl	ENST00000233202
GeneID	6556
KEGG	hsa:6556
UCSC	uc002vhu.1 uc002vhw.3
CTD	6556
GeneCards	GC02P219246
HGNC	HGNC:10907
HPA	HPA029590
MIM	600266 607948 610446
neXtProt	NX_P49279
Orphanet	3389
PharmGKB	PA319
eggNOG	COG1914
GeneTree	ENSGT00390000006526
HOGENOM	HOG000152203
HOVERGEN	HBG052665
InParanoid	P49279
KO	K12347
OMA	TSMPTLM
OrthoDB	EOG77127K
PhylomeDB	P49279
TreeFam	TF315185
Reactome	REACT_121256 REACT_20547
ChiTaRS	SLC11A1
GeneWiki	SLC11A1
GenomeRNAi	6556
NextBio	25511
PRO	PR:P49279
Proteomes	UP000005640
Bgee	P49279
CleanEx	HS_SLC11A1
ExpressionAtlas	P49279
Genevestigator	P49279
GO	GO:0009279 GO:0005887 GO:0005770 GO:0031902 GO:0005764 GO:0030670 GO:0005886 GO:0070821 GO:0005384 GO:0051139 GO:0042803 GO:0046915 GO:0032147 GO:0048002 GO:0070574 GO:0006876 GO:0006879 GO:0042742 GO:0050829 GO:0042832 GO:0070839 GO:0006954 GO:0051701 GO:0032623 GO:0032632 GO:0055072 GO:0006826 GO:0043091 GO:0042116 GO:0006828 GO:0045342 GO:0048255 GO:0060586 GO:0001818 GO:0015707 GO:0006909 GO:0090382 GO:0001819 GO:0002606 GO:0010628 GO:0032729 GO:0050766 GO:0002827 GO:0045944 GO:0000060 GO:0045730 GO:0009617 GO:0034341 GO:0032496 GO:0002369 GO:0002309 GO:0055085 GO:0007035 GO:0042060
HAMAP	MF_00221
InterPro	IPR001046
PANTHER	PTHR11706
Pfam	PF01566
PRINTS	PR00447
TIGRFAMs	TIGR01197

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009617	response to bacterium	PMID:7717395^[1]	ECO:0000314			P	Seeded from UniProt.	complete
	GO:0070821	tertiary granule membrane	PMID:12070036^[2]	ECO:0000314			C	New term component: tertiary granule membrane	complete
involved_in	GO:0070839	divalent metal ion export	PMID:17932044^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	PMID:12070036^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070574	cadmium ion transmembrane transport	PMID:17932044^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P38356	P	Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
enables	GO:0051139	metal ion:proton antiporter activity	PMID:17932044^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P38356	F	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0048255	mRNA stabilization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0048002	antigen processing and presentation of peptide antigen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
enables	GO:0046915	transition metal ion transmembrane transporter activity	PMID:17932044^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P38356	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0045730	respiratory burst	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0045342	MHC class II biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0034341	response to interferon-gamma	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0032632	interleukin-3 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0032623	interleukin-2 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	PMID:12070036^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0015707	nitrite transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0007035	vacuolar acidification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:16510578^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006876	cellular cadmium ion homeostasis	PMID:17932044^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P38356	P	Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	PMID:16510578^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17932044^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	C	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	F	Seeded From UniProt	complete
involved_in	GO:0002827	positive regulation of T-helper 1 type immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0002369	T cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0002309	T cell proliferation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41251	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8537108^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:7717395^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8537108^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0051139	metal ion:proton antiporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194440 UniProtKB:P49279 UniProtKB:P51027	F	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345275 PANTHER:PTN000194440 UniProtKB:O77741	P	Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345275 PANTHER:PTN000194440 UniProtKB:P49279	C	Seeded From UniProt	complete
enables	GO:0015086	cadmium ion transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2200437 UniProtKB:P49281 UniProtKB:P51027	F	Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345275 PANTHER:PTN000194440 UniProtKB:O77741 UniProtKB:P49279	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345275 PANTHER:PTN000194440 UniProtKB:P49279	P	Seeded From UniProt	complete
involved_in	GO:0006876	cellular cadmium ion homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000194440 UniProtKB:P49279 UniProtKB:P51027	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1345279 PANTHER:PTN000194437 UniProtKB:P49279 UniProtKB:P49281 UniProtKB:P51027	C	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281 UniProtKB:Q6ZG85	F	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG14157 FB:FBgn0011672 MGI:MGI:1345275 PANTHER:PTN000194431 RGD:3684 TAIR:locus:2025677 TAIR:locus:2036751 UniProtKB:P49281	F	Seeded From UniProt	complete
enables	GO:0005381	iron ion transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011672 MGI:MGI:1345279 PANTHER:PTN000194435 RGD:3684 UniProtKB:P49281 ZFIN:ZDB-GENE-021115-1 dictyBase:DDB_G0276973	F	Seeded From UniProt	complete
involved_in	GO:0034755	iron ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005381	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:0071421	manganese ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005384	P	Seeded From UniProt	complete
involved_in	GO:1902023	L-arginine transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0070839	divalent metal ion export	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0060586	multicellular organismal iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0048255	mRNA stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0048002	antigen processing and presentation of peptide antigen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0045730	respiratory burst	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0045342	MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0042832	defense response to protozoan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0034341	response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0032632	interleukin-3 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0032623	interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	C	Seeded From UniProt	complete
involved_in	GO:0015707	nitrite transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	C	Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0007035	vacuolar acidification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0006828	manganese ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0006826	iron ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	C	Seeded From UniProt	complete
enables	GO:0005384	manganese ion transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	F	Seeded From UniProt	complete
involved_in	GO:0002827	positive regulation of T-helper 1 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0002369	T cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0002309	T cell proliferation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41251 ensembl:ENSMUSP00000027368	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	C	Seeded From UniProt	complete
involved_in	GO:0030001	metal ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	P	Seeded From UniProt	complete
enables	GO:0046873	metal ion transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001046	F	Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	Reactome:R-HSA-435171	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6800426 Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0101003	ficolin-1-rich granule membrane	Reactome:R-HSA-6800426	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0051139	metal ion:proton antiporter activity	Reactome:R-HSA-435171	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	Reactome:R-HSA-1222556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Liu, J et al. (1995) Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am. J. Hum. Genet. 56 845-53 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Canonne-Hergaux, F et al. (2002) Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood 100 268-75 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Techau, ME et al. (2007) Evolution of differences in transport function in Slc11a family members. J. Biol. Chem. 282 35646-56 PubMed GONUTS page
↑ ^4.0 ^4.1 Knowles, HJ et al. (2006) Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Res. 66 2600-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Kishi, F & Nobumoto, M () Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes. Immunol. Lett. 47 93-6 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7717395-1] 1.0 ^1.1 Liu, J et al. (1995) Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am. J. Hum. Genet. 56 845-53 PubMed GONUTS page

[PMID:12070036-2] 2.0 ^2.1 ^2.2 Canonne-Hergaux, F et al. (2002) Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood 100 268-75 PubMed GONUTS page

[PMID:17932044-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Techau, ME et al. (2007) Evolution of differences in transport function in Slc11a family members. J. Biol. Chem. 282 35646-56 PubMed GONUTS page

[PMID:16510578-4] 4.0 ^4.1 Knowles, HJ et al. (2006) Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Res. 66 2600-7 PubMed GONUTS page

[PMID:8537108-5] 5.0 ^5.1 Kishi, F & Nobumoto, M () Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes. Immunol. Lett. 47 93-6 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

HUMAN:NRAM1

Contents

Annotations

Notes

References

a

c

d

e

f

h

i

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools