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HUMAN:NLGN3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NLGN3 (synonyms: KIAA1480, NL3)
Protein Name(s) Neuroligin-3

Gliotactin homolog

External Links
UniProt Q9NZ94
EMBL AF217411
AF217412
AF217413
AF217413
GQ489207
AK074814
AK314699
AL590764
CH471132
CH471132
CH471132
CH471132
CH471132
CH471132
BC051715
AB040913
CCDS CCDS14407.1
CCDS55441.1
CCDS55442.1
RefSeq NP_001160132.1
NP_061850.2
NP_851820.1
UniGene Hs.438877
DisProt DP00553
ProteinModelPortal Q9NZ94
SMR Q9NZ94
BioGrid 119944
IntAct Q9NZ94
MINT MINT-199096
STRING 9606.ENSP00000363163
MEROPS S09.987
PhosphoSite Q9NZ94
DMDM 31076855
PaxDb Q9NZ94
PRIDE Q9NZ94
DNASU 54413
Ensembl ENST00000358741
ENST00000374051
ENST00000536169
GeneID 54413
KEGG hsa:54413
UCSC uc004dzb.3
uc004dzd.2
uc011mps.2
CTD 54413
GeneCards GC0XP070364
GeneReviews NLGN3
HGNC HGNC:14289
HPA HPA003183
MIM 300336
300425
300494
neXtProt NX_Q9NZ94
Orphanet 1162
106
PharmGKB PA31649
eggNOG COG2272
HOVERGEN HBG008839
InParanoid Q9NZ94
KO K07378
OMA KPNKKIC
OrthoDB EOG7RBZ7R
PhylomeDB Q9NZ94
TreeFam TF326187
ChiTaRS NLGN3
GeneWiki NLGN3
GenomeRNAi 54413
NextBio 35468089
PRO PR:Q9NZ94
Proteomes UP000005640
Bgee Q9NZ94
CleanEx HS_NLGN3
ExpressionAtlas Q9NZ94
Genevestigator Q9NZ94
GO GO:0030054
GO:0009986
GO:0030139
GO:0060076
GO:0005887
GO:0045202
GO:0050839
GO:0042043
GO:0004872
GO:0030534
GO:0048675
GO:0007612
GO:0007158
GO:0048709
GO:2000969
GO:2000463
GO:0051965
GO:0051968
GO:0097104
GO:0097105
GO:0006898
GO:0061001
GO:0060080
GO:1900271
GO:2000310
GO:0002087
GO:0050804
GO:2000331
GO:0060024
GO:0035176
GO:0007416
GO:0050808
GO:0008542
GO:0071625
Gene3D 3.40.50.1820
InterPro IPR029058
IPR002018
IPR019819
IPR000460
IPR030024
PANTHER PTHR11559:SF145
Pfam PF00135
PRINTS PR01090
SUPFAM SSF53474
PROSITE PS00941

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0097110

scaffold protein binding

PMID:17292328[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NY99

F

Seeded From UniProt

complete

involved_in

GO:2000969

positive regulation of AMPA receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BYM5

P

Seeded From UniProt

complete

involved_in

GO:2000463

positive regulation of excitatory postsynaptic potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BYM5

P

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

involved_in

GO:0097104

postsynaptic membrane assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BYM5

P

Seeded From UniProt

complete

involved_in

GO:0071625

vocalization behavior

PMID:12669065[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060080

inhibitory postsynaptic potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

part_of

GO:0060076

excitatory synapse

PMID:15620359[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060024

rhythmic synaptic transmission

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

involved_in

GO:0051968

positive regulation of synaptic transmission, glutamatergic

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BYM5

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

enables

GO:0050839

cell adhesion molecule binding

PMID:15152050[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

F

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BYM5

P

Seeded From UniProt

complete

involved_in

GO:0048675

axon extension

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

PMID:15152050[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

F

Seeded From UniProt

complete

involved_in

GO:0030534

adult behavior

PMID:12669065[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030139

endocytic vesicle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

C

Seeded From UniProt

complete

involved_in

GO:0007612

learning

PMID:12669065[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

involved_in

GO:0007158

neuron cell-cell adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

involved_in

GO:0006898

receptor-mediated endocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

P

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

C

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

F

Seeded From UniProt

complete

involved_in

GO:0002087

regulation of respiratory gaseous exchange by neurological system process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BYM5

P

Seeded From UniProt

complete

involved_in

GO:0050808

synapse organization

PMID:15150161[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62889

C

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:12669065[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:15150161[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:17292328[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119
UniProtKB:Q8N0W4

P

Seeded From UniProt

complete

involved_in

GO:0097104

postsynaptic membrane assembly

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2444609
MGI:MGI:2681835
PANTHER:PTN000168538

P

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2444609
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117

P

Seeded From UniProt

complete

involved_in

GO:0048488

synaptic vesicle endocytosis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0083963
PANTHER:PTN000168538

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2681835
MGI:MGI:3775191
PANTHER:PTN000168538
RGD:621117
RGD:621119
WB:WBGene00006412

C

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031866
MGI:MGI:2179435
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117
RGD:621119
UniProtKB:Q8N0W4

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000168538
RGD:621117
RGD:621119

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119
UniProtKB:Q8N0W4
UniProtKB:Q9NZ94

C

Seeded From UniProt

complete

involved_in

GO:0007158

neuron cell-cell adhesion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
UniProtKB:Q8N0W4

C

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048488

C

Seeded From UniProt

complete

involved_in

GO:2000969

positive regulation of AMPA receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:2000809

positive regulation of synaptic vesicle clustering

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:2000463

positive regulation of excitatory postsynaptic potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:2000331

regulation of terminal button organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:2000311

regulation of AMPA receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:2000310

regulation of NMDA receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:1900271

regulation of long-term synaptic potentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0097104

postsynaptic membrane assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0090394

negative regulation of excitatory postsynaptic potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0061002

negative regulation of dendritic spine morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0061001

regulation of dendritic spine morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0060291

long-term synaptic potentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0060080

inhibitory postsynaptic potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0051968

positive regulation of synaptic transmission, glutamatergic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0051966

regulation of synaptic transmission, glutamatergic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0050808

synapse organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0048709

oligodendrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0008542

visual learning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

involved_in

GO:0002087

regulation of respiratory gaseous exchange by neurological system process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BYM5
ensembl:ENSMUSP00000066304

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030024

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030024

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000460

C

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000460
InterPro:IPR030024

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030024

C

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030024

P

Seeded From UniProt

complete

involved_in

GO:0050808

synapse organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030024

P

Seeded From UniProt

complete

part_of

GO:0098985

asymmetric, glutamatergic, excitatory synapse

PMID:21838267[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098983

symmetric, GABA-ergic, inhibitory synapse

PMID:21838267[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0089717

spanning component of membrane

PMID:21838267[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0099054

presynapse assembly

PMID:21838267[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6797568
Reactome:R-HSA-6797554
Reactome:R-HSA-6794346

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770
UniProtKB-SubCell:SL-0258

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Yamakawa, H et al. (2007) Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. Biochem. Biophys. Res. Commun. 355 41-6 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Jamain, S et al. (2003) Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat. Genet. 34 27-9 PubMed GONUTS page
  3. Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
  4. 4.0 4.1 Comoletti, D et al. (2004) The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J. Neurosci. 24 4889-93 PubMed GONUTS page
  5. 5.0 5.1 Chih, B et al. (2004) Disorder-associated mutations lead to functional inactivation of neuroligins. Hum. Mol. Genet. 13 1471-7 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Dinamarca, MC et al. (2011) The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry 50 8127-37 PubMed GONUTS page