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HUMAN:NLGN3
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | NLGN3 (synonyms: KIAA1480, NL3) | |
Protein Name(s) | Neuroligin-3
Gliotactin homolog | |
External Links | ||
UniProt | Q9NZ94 | |
EMBL | AF217411 AF217412 AF217413 AF217413 GQ489207 AK074814 AK314699 AL590764 CH471132 CH471132 CH471132 CH471132 CH471132 CH471132 BC051715 AB040913 | |
CCDS | CCDS14407.1 CCDS55441.1 CCDS55442.1 | |
RefSeq | NP_001160132.1 NP_061850.2 NP_851820.1 | |
UniGene | Hs.438877 | |
DisProt | DP00553 | |
ProteinModelPortal | Q9NZ94 | |
SMR | Q9NZ94 | |
BioGrid | 119944 | |
IntAct | Q9NZ94 | |
MINT | MINT-199096 | |
STRING | 9606.ENSP00000363163 | |
MEROPS | S09.987 | |
PhosphoSite | Q9NZ94 | |
DMDM | 31076855 | |
PaxDb | Q9NZ94 | |
PRIDE | Q9NZ94 | |
DNASU | 54413 | |
Ensembl | ENST00000358741 ENST00000374051 ENST00000536169 | |
GeneID | 54413 | |
KEGG | hsa:54413 | |
UCSC | uc004dzb.3 uc004dzd.2 uc011mps.2 | |
CTD | 54413 | |
GeneCards | GC0XP070364 | |
GeneReviews | NLGN3 | |
HGNC | HGNC:14289 | |
HPA | HPA003183 | |
MIM | 300336 300425 300494 | |
neXtProt | NX_Q9NZ94 | |
Orphanet | 1162 106 | |
PharmGKB | PA31649 | |
eggNOG | COG2272 | |
HOVERGEN | HBG008839 | |
InParanoid | Q9NZ94 | |
KO | K07378 | |
OMA | KPNKKIC | |
OrthoDB | EOG7RBZ7R | |
PhylomeDB | Q9NZ94 | |
TreeFam | TF326187 | |
ChiTaRS | NLGN3 | |
GeneWiki | NLGN3 | |
GenomeRNAi | 54413 | |
NextBio | 35468089 | |
PRO | PR:Q9NZ94 | |
Proteomes | UP000005640 | |
Bgee | Q9NZ94 | |
CleanEx | HS_NLGN3 | |
ExpressionAtlas | Q9NZ94 | |
Genevestigator | Q9NZ94 | |
GO | GO:0030054 GO:0009986 GO:0030139 GO:0060076 GO:0005887 GO:0045202 GO:0050839 GO:0042043 GO:0004872 GO:0030534 GO:0048675 GO:0007612 GO:0007158 GO:0048709 GO:2000969 GO:2000463 GO:0051965 GO:0051968 GO:0097104 GO:0097105 GO:0006898 GO:0061001 GO:0060080 GO:1900271 GO:2000310 GO:0002087 GO:0050804 GO:2000331 GO:0060024 GO:0035176 GO:0007416 GO:0050808 GO:0008542 GO:0071625 | |
Gene3D | 3.40.50.1820 | |
InterPro | IPR029058 IPR002018 IPR019819 IPR000460 IPR030024 | |
PANTHER | PTHR11559:SF145 | |
Pfam | PF00135 | |
PRINTS | PR01090 | |
SUPFAM | SSF53474 | |
PROSITE | PS00941 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000969 |
positive regulation of AMPA receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000463 |
positive regulation of excitatory postsynaptic potential |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097105 |
presynaptic membrane assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097104 |
postsynaptic membrane assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071625 |
vocalization behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060080 |
inhibitory postsynaptic potential |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0060076 |
excitatory synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060024 |
rhythmic synaptic transmission |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051965 |
positive regulation of synapse assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050839 |
cell adhesion molecule binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048675 |
axon extension |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042043 |
neurexin family protein binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030534 |
adult behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030139 |
endocytic vesicle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007612 |
learning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007416 |
synapse assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007158 |
neuron cell-cell adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006898 |
receptor-mediated endocytosis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0099055 |
integral component of postsynaptic membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002087 |
regulation of respiratory gaseous exchange by neurological system process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050808 |
synapse organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035176 |
social behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097105 |
presynaptic membrane assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097104 |
postsynaptic membrane assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048488 |
synaptic vesicle endocytosis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0083963 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0042043 |
neurexin family protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0031866 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000168538 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007158 |
neuron cell-cell adhesion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2179435 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098793 |
presynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048488 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000969 |
positive regulation of AMPA receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000809 |
positive regulation of synaptic vesicle clustering |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000463 |
positive regulation of excitatory postsynaptic potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000331 |
regulation of terminal button organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000311 |
regulation of AMPA receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000310 |
regulation of NMDA receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900271 |
regulation of long-term synaptic potentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097104 |
postsynaptic membrane assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090394 |
negative regulation of excitatory postsynaptic potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061002 |
negative regulation of dendritic spine morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061001 |
regulation of dendritic spine morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060291 |
long-term synaptic potentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060080 |
inhibitory postsynaptic potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051965 |
positive regulation of synapse assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050808 |
synapse organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048709 |
oligodendrocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035176 |
social behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008542 |
visual learning |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002087 |
regulation of respiratory gaseous exchange by neurological system process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYM5 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0042043 |
neurexin family protein binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050808 |
synapse organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0098985 |
asymmetric, glutamatergic, excitatory synapse |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098983 |
symmetric, GABA-ergic, inhibitory synapse |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0089717 |
spanning component of membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0099054 |
presynapse assembly |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-6797568 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Yamakawa, H et al. (2007) Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations. Biochem. Biophys. Res. Commun. 355 41-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Jamain, S et al. (2003) Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat. Genet. 34 27-9 PubMed GONUTS page
- ↑ Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
- ↑ 4.0 4.1 Comoletti, D et al. (2004) The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J. Neurosci. 24 4889-93 PubMed GONUTS page
- ↑ 5.0 5.1 Chih, B et al. (2004) Disorder-associated mutations lead to functional inactivation of neuroligins. Hum. Mol. Genet. 13 1471-7 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Dinamarca, MC et al. (2011) The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry 50 8127-37 PubMed GONUTS page
a
c
e
i
n
o
p
- GO:0005886 ! plasma membrane
- GO:2000969 ! positive regulation of AMPA receptor activity
- GO:0051965 ! positive regulation of synapse assembly
- GO:2000809 ! positive regulation of synaptic vesicle clustering
- GO:0051968 ! positive regulation of synaptic transmission, glutamatergic
- GO:2000463 ! positive regulation of excitatory postsynaptic potential
- GO:0097104 ! postsynaptic membrane assembly
- GO:0098793 ! presynapse
- GO:0099054 ! presynapse assembly
- GO:0097105 ! presynaptic membrane assembly
- Primates
r
- GO:0006898 ! receptor-mediated endocytosis
- GO:2000310 ! regulation of NMDA receptor activity
- GO:0002087 ! regulation of respiratory gaseous exchange by nervous system process
- GO:0051966 ! regulation of synaptic transmission, glutamatergic
- GO:0061001 ! regulation of dendritic spine morphogenesis
- GO:1900271 ! regulation of long-term synaptic potentiation
- GO:2000311 ! regulation of AMPA receptor activity
- GO:2000331 ! regulation of terminal button organization
- GO:0060024 ! rhythmic synaptic transmission
s