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HUMAN:NEUR3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NEU3 | |
| Protein Name(s) | Sialidase-3
Ganglioside sialidase Membrane sialidase N-acetyl-alpha-neuraminidase 3 | |
| External Links | ||
| UniProt | Q9UQ49 | |
| EMBL | AB008185 Y18563 AK022450 AK290442 AP001992 CH471076 BC136397 BC144059 | |
| CCDS | CCDS44682.1 | |
| RefSeq | NP_006647.3 | |
| UniGene | Hs.191074 | |
| ProteinModelPortal | Q9UQ49 | |
| SMR | Q9UQ49 | |
| STRING | 9606.ENSP00000294064 | |
| BindingDB | Q9UQ49 | |
| ChEMBL | CHEMBL3046 | |
| CAZy | GH33 | |
| PhosphoSite | Q9UQ49 | |
| DMDM | 17369720 | |
| MaxQB | Q9UQ49 | |
| PaxDb | Q9UQ49 | |
| PRIDE | Q9UQ49 | |
| Ensembl | ENST00000294064 ENST00000531509 | |
| GeneID | 10825 | |
| KEGG | hsa:10825 | |
| UCSC | uc001ovv.3 uc010rrl.2 | |
| CTD | 10825 | |
| GeneCards | GC11P074699 | |
| HGNC | HGNC:7760 | |
| HPA | HPA038729 HPA038730 | |
| MIM | 604617 | |
| neXtProt | NX_Q9UQ49 | |
| eggNOG | NOG84455 | |
| GeneTree | ENSGT00390000011171 | |
| HOVERGEN | HBG052608 | |
| InParanoid | Q9UQ49 | |
| KO | K12357 | |
| OMA | VYLFFIC | |
| OrthoDB | EOG7MSMNP | |
| PhylomeDB | Q9UQ49 | |
| BRENDA | 3.2.1.18 | |
| Reactome | REACT_116105 REACT_200874 | |
| SABIO-RK | Q9UQ49 | |
| GeneWiki | NEU3 | |
| GenomeRNAi | 10825 | |
| NextBio | 41116 | |
| PRO | PR:Q9UQ49 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UQ49 | |
| CleanEx | HS_NEU3 | |
| ExpressionAtlas | Q9UQ49 | |
| Genevestigator | Q9UQ49 | |
| GO | GO:0005887 GO:0005886 GO:0016997 GO:0052794 GO:0052795 GO:0052796 GO:0004308 GO:0005975 GO:0006689 GO:0006687 GO:0009313 GO:0044281 GO:0006665 | |
| Gene3D | 2.120.10.10 | |
| InterPro | IPR026944 IPR026856 IPR011040 | |
| PANTHER | PTHR10628 PTHR10628:SF7 | |
| SUPFAM | SSF50939 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0052796 |
exo-alpha-(2->8)-sialidase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052794 |
exo-alpha-(2->3)-sialidase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009313 |
oligosaccharide catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006689 |
ganglioside catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004308 |
exo-alpha-sialidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000066595 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000066595 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009313 |
oligosaccharide catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000066595 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006689 |
ganglioside catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000066595 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000066595 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004308 |
exo-alpha-sialidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2661364 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016997 |
alpha-sialidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004308 |
exo-alpha-sialidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052796 |
exo-alpha-(2->8)-sialidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052795 |
exo-alpha-(2->6)-sialidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052794 |
exo-alpha-(2->3)-sialidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004308 |
exo-alpha-sialidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006687 |
glycosphingolipid metabolic process |
Reactome:R-HSA-1660662 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-4084994 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0004308 |
exo-alpha-sialidase activity |
Reactome:R-HSA-4084994 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Monti, E et al. (2000) Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem. J. 349 343-51 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Sasaki, A et al. (2003) Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice. J. Biol. Chem. 278 27896-902 PubMed GONUTS page
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