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HUMAN:NEUR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NEU1 (synonyms: NANH)
Protein Name(s) Sialidase-1

Acetylneuraminyl hydrolase G9 sialidase Lysosomal sialidase N-acetyl-alpha-neuraminidase 1

External Links
UniProt Q99519
EMBL AF040958
X78687
U84246
AF134726
BA000025
BT007206
BC000722
BC011900
CCDS CCDS4723.1
RefSeq NP_000425.1
UniGene Hs.520037
ProteinModelPortal Q99519
SMR Q99519
BioGrid 110831
IntAct Q99519
MINT MINT-1389413
STRING 9606.ENSP00000399309
BindingDB Q99519
ChEMBL CHEMBL2726
DrugBank DB00198
CAZy GH33
PhosphoSite Q99519
DMDM 17368612
MaxQB Q99519
PaxDb Q99519
PeptideAtlas Q99519
PRIDE Q99519
DNASU 4758
Ensembl ENST00000229725
ENST00000375631
ENST00000411774
ENST00000422978
ENST00000423382
ENST00000434496
ENST00000437432
ENST00000439648
GeneID 4758
KEGG hsa:4758
UCSC uc003nxq.4
CTD 4758
GeneCards GC06M031825
GC06Mi31836
GC06Mj31813
GC06Mk31807
GC06Ml31865
GC06Mm31901
GC06Mn31815
GC06Mo31817
HGNC HGNC:7758
HPA HPA015634
HPA021506
MIM 256550
608272
neXtProt NX_Q99519
Orphanet 93400
93399
812
PharmGKB PA31560
eggNOG COG4409
GeneTree ENSGT00720000108878
HOGENOM HOG000007651
HOVERGEN HBG057314
InParanoid Q99519
KO K01186
OMA GTEMFAP
PhylomeDB Q99519
TreeFam TF331063
BRENDA 3.2.1.18
Reactome REACT_116105
REACT_200874
SABIO-RK Q99519
ChiTaRS NEU1
GeneWiki NEU1
GenomeRNAi 4758
NextBio 18328
PRO PR:Q99519
Proteomes UP000005640
UP000005640
Bgee Q99519
CleanEx HS_NEU1
ExpressionAtlas Q99519
Genevestigator Q99519
GO GO:0030054
GO:0016023
GO:0070062
GO:0043231
GO:0043202
GO:0005765
GO:0005764
GO:0005886
GO:0052794
GO:0052795
GO:0052796
GO:0004308
GO:0006687
GO:0016042
GO:0009313
GO:0044281
GO:0006665
Gene3D 2.120.10.10
InterPro IPR026856
IPR011040
PANTHER PTHR10628
SUPFAM SSF50939

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005764

lysosome

PMID:25153125[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016997

alpha-sialidase activity

PMID:25153125[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

involved_in

GO:0009313

oligosaccharide catabolic process

PMID:8985184[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:8985184[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004308

exo-alpha-sialidase activity

PMID:8985184[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000066595
UniProtKB:Q99519

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000066595
ZFIN:ZDB-GENE-061103-511

C

Seeded From UniProt

complete

involved_in

GO:0009313

oligosaccharide catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000066595
UniProtKB:Q8WWR8
UniProtKB:Q99519
UniProtKB:Q9UQ49
UniProtKB:Q9Y3R4

P

Seeded From UniProt

complete

involved_in

GO:0006689

ganglioside catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000066595
UniProtKB:O97859
UniProtKB:Q8WWR8
UniProtKB:Q9UQ49
UniProtKB:Q9Y3R4

P

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97305
PANTHER:PTN000835989
RGD:3163
UniProtKB:Q99519

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000066595
RGD:3164

C

Seeded From UniProt

complete

enables

GO:0004308

exo-alpha-sialidase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2661364
MGI:MGI:97305
PANTHER:PTN000066595
RGD:3163
RGD:3164
UniProtKB:Q4WQS0
UniProtKB:Q8WWR8
UniProtKB:Q99519
UniProtKB:Q9UQ49
UniProtKB:Q9Y3R4
ZFIN:ZDB-GENE-040801-262

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35657
ensembl:ENSMUSP00000007253

C

Seeded From UniProt

complete

enables

GO:0004308

exo-alpha-sialidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35657
ensembl:ENSMUSP00000007253

F

Seeded From UniProt

complete

enables

GO:0004308

exo-alpha-sialidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026856

F

Seeded From UniProt

complete

enables

GO:0052795

exo-alpha-(2->6)-sialidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.18

F

Seeded From UniProt

complete

enables

GO:0052796

exo-alpha-(2->8)-sialidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.18

F

Seeded From UniProt

complete

enables

GO:0004308

exo-alpha-sialidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.18

F

Seeded From UniProt

complete

enables

GO:0052794

exo-alpha-(2->3)-sialidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.18

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043202

lysosomal lumen

Reactome:R-HSA-4084999
Reactome:R-HSA-1605724

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0035580

specific granule lumen

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006687

glycosphingolipid metabolic process

Reactome:R-HSA-1660662

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004308

exo-alpha-sialidase activity

Reactome:R-HSA-4084999

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0442

P

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0157

C

Seeded From UniProt

complete

part_of

GO:0043202

lysosomal lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0156

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Bonardi, D et al. (2014) In silico identification of new putative pathogenic variants in the NEU1 sialidase gene affecting enzyme function and subcellular localization. PLoS ONE 9 e104229 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Bonten, E et al. (1996) Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis. Genes Dev. 10 3156-69 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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