GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:NB5R4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CYB5R4 (synonyms: NCB5OR) | |
| Protein Name(s) | Cytochrome b5 reductase 4
Flavohemoprotein b5/b5R b5+b5R N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein cb5/cb5R | |
| External Links | ||
| UniProt | Q7L1T6 | |
| EMBL | EU448291 AL139232 AL034347 AL034347 AL139232 AL034347 AL139232 AL139232 AL034347 BC025380 AF169803 | |
| CCDS | CCDS5000.2 | |
| RefSeq | NP_057314.2 | |
| UniGene | Hs.5741 | |
| PDB | 3LF5 | |
| PDBsum | 3LF5 | |
| ProteinModelPortal | Q7L1T6 | |
| SMR | Q7L1T6 | |
| BioGrid | 119347 | |
| IntAct | Q7L1T6 | |
| MINT | MINT-4714403 | |
| STRING | 9606.ENSP00000358695 | |
| PhosphoSite | Q7L1T6 | |
| BioMuta | CYB5R4 | |
| EPD | Q7L1T6 | |
| MaxQB | Q7L1T6 | |
| PaxDb | Q7L1T6 | |
| PRIDE | Q7L1T6 | |
| TopDownProteomics | Q7L1T6 | |
| DNASU | 51167 | |
| Ensembl | ENST00000369681 | |
| GeneID | 51167 | |
| KEGG | hsa:51167 | |
| UCSC | uc003pkf.4 | |
| CTD | 51167 | |
| GeneCards | CYB5R4 | |
| HGNC | HGNC:20147 | |
| HPA | HPA018992 | |
| MIM | 608343 | |
| neXtProt | NX_Q7L1T6 | |
| PharmGKB | PA134904907 | |
| eggNOG | KOG0534 KOG0536 COG0543 COG5274 | |
| GeneTree | ENSGT00390000008881 | |
| HOGENOM | HOG000230826 | |
| HOVERGEN | HBG108174 | |
| InParanoid | Q7L1T6 | |
| KO | K00326 | |
| OMA | KDYHEEK | |
| OrthoDB | EOG718KBZ | |
| PhylomeDB | Q7L1T6 | |
| TreeFam | TF313874 | |
| BRENDA | 1.6.2.2 | |
| EvolutionaryTrace | Q7L1T6 | |
| GeneWiki | CYB5R4 | |
| GenomeRNAi | 51167 | |
| NextBio | 54103 | |
| PRO | PR:Q7L1T6 | |
| Proteomes | UP000005640 | |
| Bgee | Q7L1T6 | |
| CleanEx | HS_CYB5R4 | |
| ExpressionAtlas | Q7L1T6 | |
| Genevisible | Q7L1T6 | |
| GO | GO:0005783 GO:0048471 GO:0004128 GO:0050660 GO:0020037 GO:0046872 GO:0016174 GO:0003958 GO:0016653 GO:0048468 GO:0003032 GO:0006091 GO:0042593 GO:0030073 GO:0006739 GO:0055114 GO:0046677 GO:0006801 | |
| Gene3D | 2.60.40.790 3.10.120.10 | |
| InterPro | IPR007052 IPR001199 IPR018506 IPR017927 IPR008978 IPR001834 IPR008333 IPR001433 IPR017938 | |
| Pfam | PF04969 PF00173 PF00970 PF00175 | |
| PRINTS | PR00406 PR00363 | |
| SUPFAM | SSF49764 SSF55856 SSF63380 | |
| PROSITE | PS51203 PS00191 PS50255 PS51384 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048468 |
cell development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030073 |
insulin secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016653 |
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0016174 |
NAD(P)H oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016174 |
NAD(P)H oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006091 |
generation of precursor metabolites and energy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004128 |
cytochrome-b5 reductase activity, acting on NAD(P)H |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003032 |
detection of oxygen |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000452141 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006091 |
generation of precursor metabolites and energy |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000452141 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2386848 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048468 |
cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3TDX8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3TDX8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3TDX8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030073 |
insulin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3TDX8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3TDX8 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004128 |
cytochrome-b5 reductase activity, acting on NAD(P)H |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3TDX8 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0020037 |
heme binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004128 |
cytochrome-b5 reductase activity, acting on NAD(P)H |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015701 |
bicarbonate transport |
Reactome:R-HSA-1237044 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-6806831 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zhu, H et al. (2004) NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J. Biol. Chem. 279 30316-25 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Zhu, H et al. (1999) Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc. Natl. Acad. Sci. U.S.A. 96 14742-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
o
