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HUMAN:MYP0

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MPZ
Protein Name(s) Myelin protein P0

Myelin peripheral protein MPP Myelin protein zero

External Links
UniProt P25189
EMBL D10537
D14720
L24893
L24894
AK313555
BT006765
AL592295
CH471121
BC006491
S66705
U10018
U10017
CCDS CCDS1229.2
PIR JH0252
RefSeq NP_000521.2
UniGene Hs.591486
PDB 1N2P
3OAI
PDBsum 1N2P
3OAI
ProteinModelPortal P25189
SMR P25189
BioGrid 110499
IntAct P25189
MINT MINT-1390651
STRING 9606.ENSP00000353634
PhosphoSite P25189
DMDM 127721
MaxQB P25189
PaxDb P25189
PRIDE P25189
DNASU 4359
Ensembl ENST00000463290
ENST00000533357
GeneID 4359
KEGG hsa:4359
UCSC uc001gaf.4
CTD 4359
GeneCards GC01M161274
GeneReviews MPZ
HGNC HGNC:7225
MIM 103100
118200
145900
159440
180800
605253
607677
607736
607791
neXtProt NX_P25189
Orphanet 99942
99943
100046
324585
101082
64748
3115
PharmGKB PA30930
eggNOG NOG47065
GeneTree ENSGT00640000091161
HOGENOM HOG000232144
HOVERGEN HBG096384
InParanoid P25189
KO K06770
OrthoDB EOG7G1V80
PhylomeDB P25189
TreeFam TF331728
GeneWiki Myelin_protein_zero
GenomeRNAi 4359
NextBio 17155
PRO PR:P25189
Proteomes UP000005640
Bgee P25189
CleanEx HS_MPZ
ExpressionAtlas P25189
Genevestigator P25189
GO GO:0005887
GO:0043209
GO:0005886
GO:0005198
GO:0045217
GO:0007268
Gene3D 2.60.40.10
InterPro IPR007110
IPR013783
IPR013106
IPR003596
IPR019566
IPR019738
IPR000920
IPR029869
PANTHER PTHR13869
PTHR13869:SF7
Pfam PF10570
PF07686
PRINTS PR00213
SMART SM00406
PROSITE PS50835
PS00568

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0042552

myelination

PMID:10545037[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098743

cell aggregation

PMID:18337304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

PMID:18337304[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18337304[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:7693130[3]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:7693129[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06907
ensembl:ENSRNOP00000004279

P

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06907
ensembl:ENSRNOP00000004279

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06907
ensembl:ENSRNOP00000004279

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06907
ensembl:ENSRNOP00000004279

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06907
ensembl:ENSRNOP00000004279

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029869

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000920

C

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029869

C

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:7693129[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7506095[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0176

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Lagueny, A et al. (1999) Peripheral myelin modification in CMT1B correlates with MPZ gene mutations. Neuromuscul. Disord. 9 361-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Grandis, M et al. (2008) Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations. Hum. Mol. Genet. 17 1877-89 PubMed GONUTS page
  3. ↑ Kulkens, T et al. (1993) Deletion of the serine 34 codon from the major peripheral myelin protein P0 gene in Charcot-Marie-Tooth disease type 1B. Nat. Genet. 5 35-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 Hayasaka, K et al. (1993) Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene. Nat. Genet. 5 31-4 PubMed GONUTS page
  5. ↑ Hayasaka, K et al. (1993) De novo mutation of the myelin P0 gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III). Nat. Genet. 5 266-8 PubMed GONUTS page
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