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HUMAN:MYO7A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MYO7A (synonyms: USH1B)
Protein Name(s) Unconventional myosin-VIIa
External Links
UniProt Q13402
EMBL U39226
U55208
U55209
AP000752
AP001855
L29146
U34227
BF869194
AH006665
CCDS CCDS53683.1
CCDS53684.1
PIR A59255
A59257
I61697
RefSeq NP_000251.3
NP_001120651.2
NP_001120652.1
UniGene Hs.370421
ProteinModelPortal Q13402
SMR Q13402
BioGrid 110731
IntAct Q13402
MINT MINT-1895479
STRING 9606.ENSP00000386331
PhosphoSite Q13402
DMDM 460018219
MaxQB Q13402
PaxDb Q13402
PRIDE Q13402
DNASU 4647
Ensembl ENST00000409619
ENST00000409709
ENST00000458637
GeneID 4647
KEGG hsa:4647
UCSC uc001oyb.2
CTD 4647
GeneCards GC11P076839
GeneReviews MYO7A
H-InvDB HIX0035966
HGNC HGNC:7606
HPA CAB034059
HPA028918
MIM 276900
276903
600060
601317
neXtProt NX_Q13402
Orphanet 90635
90636
231169
231178
PharmGKB PA31411
eggNOG COG5022
GeneTree ENSGT00770000120461
HOGENOM HOG000007836
HOVERGEN HBG052557
InParanoid Q13402
KO K10359
OMA YTHYHEL
OrthoDB EOG7QG433
PhylomeDB Q13402
TreeFam TF335306
Reactome REACT_160156
ChiTaRS MYO7A
GeneWiki MYO7A
GenomeRNAi 4647
NextBio 17912
PRO PR:Q13402
Proteomes UP000005640
Bgee Q13402
CleanEx HS_MYO7A
ExpressionAtlas Q13402
Genevestigator Q13402
GO GO:0016324
GO:0005938
GO:0005737
GO:0005829
GO:0005765
GO:0042470
GO:0031477
GO:0032391
GO:0001917
GO:0001750
GO:0032420
GO:0045202
GO:0051015
GO:0030898
GO:0043531
GO:0005524
GO:0005516
GO:0000146
GO:0030507
GO:0030048
GO:0060088
GO:0050957
GO:0042462
GO:0006886
GO:0007040
GO:0001845
GO:0051904
GO:0048563
GO:0050953
GO:0007605
GO:0007601
Gene3D 1.20.80.10
2.30.29.30
InterPro IPR019749
IPR014352
IPR019748
IPR000299
IPR018979
IPR000048
IPR001609
IPR000857
IPR027417
IPR011993
IPR001452
IPR029071
Pfam PF00373
PF09379
PF00612
PF00063
PF00784
PRINTS PR00193
SMART SM00295
SM00015
SM00242
SM00139
SM00326
SUPFAM SSF47031
SSF50044
SSF52540
SSF54236
PROSITE PS50057
PS50096
PS51456
PS51016
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0032420

stereocilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97479

C

Seeded From UniProt

complete

involved_in

GO:0034613

cellular protein localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97479

P

Seeded From UniProt

complete

part_of

GO:0120044

stereocilium base

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97479

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042490

mechanoreceptor differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97479

P

Seeded From UniProt

complete

involved_in

GO:0050957

equilibrioception

PMID:7870171[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050953

sensory perception of light stimulus

PMID:11398101[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:11398101[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:21687988[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:8842737[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042462

eye photoreceptor cell development

PMID:8842737[4]

ECO:0000305

curator inference used in manual assertion

GO:0001917

P

Seeded From UniProt

complete

involved_in

GO:0030048

actin filament-based movement

PMID:21687988[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:7870171[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

PMID:7870171[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007040

lysosome organization

PMID:16001398[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15300860[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

PMID:16001398[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

PMID:15300860[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0001917

photoreceptor inner segment

PMID:8842737[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

PMID:8842737[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000146

microfilament motor activity

PMID:21687988[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030507

spectrin binding

PMID:23704327[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:7870171[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:23704327[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0120044

stereocilium base

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

involved_in

GO:0060122

inner ear receptor cell stereocilium organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0060113

inner ear receptor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0060088

auditory receptor cell stereocilium organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0051904

pigment granule transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0051875

pigment granule localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0050953

sensory perception of light stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0048839

inner ear development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0048563

post-embryonic animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

involved_in

GO:0042491

inner ear auditory receptor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0042490

mechanoreceptor differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0042472

inner ear morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

part_of

GO:0042470

melanosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

involved_in

GO:0034613

cellular protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

part_of

GO:0032420

stereocilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

part_of

GO:0032391

photoreceptor connecting cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0007600

sensory perception

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

C

Seeded From UniProt

complete

involved_in

GO:0001845

phagolysosome assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97479
ensembl:ENSMUSP00000102745

P

Seeded From UniProt

complete

part_of

GO:1990435

upper tip-link density

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

C

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0043531

ADP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

part_of

GO:0031477

myosin VII complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

C

Seeded From UniProt

complete

enables

GO:0030898

actin-dependent ATPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

involved_in

GO:0030048

actin filament-based movement

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

P

Seeded From UniProt

complete

part_of

GO:0016459

myosin complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0003774

motor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CJE3
ensembl:ENSRNOP00000019053

F

Seeded From UniProt

complete

enables

GO:0003774

motor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001609
InterPro:IPR008989

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001609
InterPro:IPR008989

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000299
InterPro:IPR000857

C

Seeded From UniProt

complete

part_of

GO:0016459

myosin complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001609

C

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008989

F

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016459

myosin complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0518

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1009

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0138

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Weil, D et al. (1995) Defective myosin VIIA gene responsible for Usher syndrome type 1B. Nature 374 60-1 PubMed GONUTS page
  2. 2.0 2.1 Ahmed, ZM et al. (2001) Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F. Am. J. Hum. Genet. 69 25-34 PubMed GONUTS page
  3. 3.0 3.1 3.2 Heissler, SM & Manstein, DJ (2012) Functional characterization of the human myosin-7a motor domain. Cell. Mol. Life Sci. 69 299-311 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 el-Amraoui, A et al. (1996) Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells. Hum. Mol. Genet. 5 1171-8 PubMed GONUTS page
  5. 5.0 5.1 Soni, LE et al. (2005) The unconventional myosin-VIIa associates with lysosomes. Cell Motil. Cytoskeleton 62 13-26 PubMed GONUTS page
  6. 6.0 6.1 Bolz, H et al. (2004) Impaired calmodulin binding of myosin-7A causes autosomal dominant hearing loss (DFNA11). Hum. Mutat. 24 274-5 PubMed GONUTS page
  7. 7.0 7.1 Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page