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HUMAN:MYLK
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MYLK (synonyms: MLCK, MLCK1, MYLK1) | |
| Protein Name(s) | Myosin light chain kinase, smooth muscle
MLCK smMLCK Kinase-related protein KRP Telokin Myosin light chain kinase, smooth muscle, deglutamylated form | |
| External Links | ||
| UniProt | Q15746 | |
| EMBL | X85337 U48959 AF069601 AF069602 AF069603 AF069604 AF096771 AF096766 AF096767 AF096768 AF096769 AF096770 AF096771 AF096769 AF096770 AF096773 AF096774 AF096775 AY424269 AY424270 AY339601 AB037663 AK300610 AK314412 AK314443 AC020634 AC023165 CH471052 CH471052 CH471052 CH471052 BC100761 BC100762 BC100763 BC064420 X90870 | |
| CCDS | CCDS3023.1 CCDS43141.1 CCDS46896.1 CCDS46897.1 CCDS58849.1 | |
| RefSeq | NP_444253.3 NP_444254.3 NP_444255.3 NP_444256.3 NP_444259.1 NP_444260.1 | |
| UniGene | Hs.477375 | |
| PDB | 2CQV 2K0F 2YR3 | |
| PDBsum | 2CQV 2K0F 2YR3 | |
| ProteinModelPortal | Q15746 | |
| SMR | Q15746 | |
| BioGrid | 110722 | |
| IntAct | Q15746 | |
| MINT | MINT-2807402 | |
| BindingDB | Q15746 | |
| ChEMBL | CHEMBL2428 | |
| GuidetoPHARMACOLOGY | 1552 | |
| MEROPS | I43.001 | |
| PhosphoSite | Q15746 | |
| DMDM | 300669714 | |
| MaxQB | Q15746 | |
| PaxDb | Q15746 | |
| PRIDE | Q15746 | |
| DNASU | 4638 | |
| Ensembl | ENST00000346322 ENST00000354792 ENST00000359169 ENST00000360304 ENST00000360772 ENST00000418370 ENST00000475616 ENST00000578202 ENST00000583087 | |
| GeneID | 4638 | |
| KEGG | hsa:4638 | |
| UCSC | uc003egl.3 uc003egm.3 uc003ego.3 uc003egp.3 uc003egq.3 uc003egr.3 uc011bjv.2 uc011bjw.2 | |
| CTD | 4638 | |
| GeneCards | GC03M123281 | |
| GeneReviews | MYLK | |
| HGNC | HGNC:7590 | |
| HPA | CAB009628 CAB020789 HPA031677 | |
| MIM | 600922 613780 | |
| neXtProt | NX_Q15746 | |
| Orphanet | 91387 | |
| PharmGKB | PA31388 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000118877 | |
| HOGENOM | HOG000049287 | |
| HOVERGEN | HBG052551 | |
| InParanoid | Q15746 | |
| KO | K00907 | |
| OMA | KFIILSQ | |
| OrthoDB | EOG7WQ7RC | |
| PhylomeDB | Q15746 | |
| TreeFam | TF314166 | |
| BRENDA | 2.7.11.18 | |
| Reactome | REACT_20558 | |
| SignaLink | Q15746 | |
| ChiTaRS | MYLK | |
| EvolutionaryTrace | Q15746 | |
| GeneWiki | MYLK | |
| GenomeRNAi | 4638 | |
| NextBio | 17860 | |
| PRO | PR:Q15746 | |
| Proteomes | UP000005640 | |
| Bgee | Q15746 | |
| ExpressionAtlas | Q15746 | |
| Genevestigator | Q15746 | |
| GO | GO:0005911 GO:0032154 GO:0005737 GO:0005829 GO:0070062 GO:0030027 GO:0001725 GO:0005524 GO:0004683 GO:0046872 GO:0004687 GO:0007015 GO:0060414 GO:0032060 GO:0071476 GO:0006936 GO:0051928 GO:0030335 GO:0090303 GO:0006468 GO:0006939 GO:0014820 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR011009 IPR020675 IPR000719 IPR017441 IPR002290 IPR008271 IPR015725 | |
| PANTHER | PTHR22964 PTHR22964:SF44 | |
| Pfam | PF00041 PF07679 PF00069 | |
| SMART | SM00060 SM00409 SM00408 SM00220 | |
| SUPFAM | SSF49265 SSF56112 | |
| PROSITE | PS50853 PS50835 PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060414 |
aorta smooth muscle tissue morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090303 |
positive regulation of wound healing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071476 |
cellular hypotonic response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051928 |
positive regulation of calcium ion transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032154 |
cleavage furrow |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032060 |
bleb assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014820 |
tonic smooth muscle contraction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006939 |
smooth muscle contraction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004687 |
myosin light chain kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001725 |
stress fiber |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072358 |
cardiovascular system development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109282 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032154 |
cleavage furrow |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000539685 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000539685 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014820 |
tonic smooth muscle contraction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:894806 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006939 |
smooth muscle contraction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:894806 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000539685 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004687 |
myosin light chain kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000539685 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2681862 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001725 |
stress fiber |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000539685 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004687 |
myosin light chain kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004687 |
myosin light chain kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006936 |
muscle contraction |
Reactome:R-HSA-445355 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5668984 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032154 |
cleavage furrow |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Wang, L et al. (2010) Mutations in myosin light chain kinase cause familial aortic dissections. Am. J. Hum. Genet. 87 701-7 PubMed GONUTS page
- ↑ Russo, JM et al. (2005) Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology 128 987-1001 PubMed GONUTS page
- ↑ Shen, MR et al. (2002) Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. Pflugers Arch. 444 276-85 PubMed GONUTS page
- ↑ 4.0 4.1 Shimizu, S et al. (2006) Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. J. Physiol. (Lond.) 570 219-35 PubMed GONUTS page
- ↑ 5.0 5.1 Dulyaninova, NG et al. (2004) The N-terminus of the long MLCK induces a disruption in normal spindle morphology and metaphase arrest. J. Cell. Sci. 117 1481-93 PubMed GONUTS page
- ↑ Godin, CM & Ferguson, SS (2010) The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase. Mol. Pharmacol. 77 903-11 PubMed GONUTS page
- ↑ Shin, DH et al. (2009) Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase. PLoS ONE 4 e7451 PubMed GONUTS page
- ↑ 8.0 8.1 Brown, M et al. (2010) Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. Microvasc. Res. 80 75-88 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 10.0 10.1 Potier, MC et al. (1995) The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. Genomics 29 562-70 PubMed GONUTS page
a
c
m
p
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0051928 ! positive regulation of calcium ion transport
- GO:0030335 ! positive regulation of cell migration
- GO:0090303 ! positive regulation of wound healing
- Primates
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
