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HUMAN:MTRR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MTRR
Protein Name(s) Methionine synthase reductase

MSR

External Links
UniProt Q9UBK8
EMBL AF121213
AF121202
AF121203
AF121204
AF121205
AF121206
AF121207
AF121208
AF121209
AF121210
AF121211
AF121212
AF121214
AF121213
AF121202
AF121203
AF121204
AF121205
AF121206
AF121207
AF121208
AF121209
AF121210
AF121211
AF121212
AF025794
AC010346
AC025174
BC054816
BC109216
CCDS CCDS3874.1
CCDS47190.1
RefSeq NP_002445.2
NP_076915.2
UniGene Hs.481551
PDB 2QTL
2QTZ
PDBsum 2QTL
2QTZ
ProteinModelPortal Q9UBK8
SMR Q9UBK8
BioGrid 110645
STRING 9606.ENSP00000264668
DrugBank DB00115
DB00200
DB00134
PhosphoSite Q9UBK8
DMDM 296439300
MaxQB Q9UBK8
PaxDb Q9UBK8
PRIDE Q9UBK8
Ensembl ENST00000264668
ENST00000440940
ENST00000510279
ENST00000514369
GeneID 4552
KEGG hsa:4552
UCSC uc003jed.3
CTD 4552
GeneCards GC05P007851
GeneReviews MTRR
H-InvDB HIX0031952
HGNC HGNC:7473
HPA HPA038113
MIM 236270
601634
602568
neXtProt NX_Q9UBK8
Orphanet 2169
PharmGKB PA31277
eggNOG COG0369
GeneTree ENSGT00620000087711
HOGENOM HOG000007485
HOVERGEN HBG108376
InParanoid Q9UBK8
KO K00597
OMA AKDVNDT
OrthoDB EOG7NCV31
PhylomeDB Q9UBK8
TreeFam TF105716
BioCyc MetaCyc:HS04756-MONOMER
Reactome REACT_115639
REACT_163862
REACT_169149
REACT_169439
REACT_6946
SABIO-RK Q9UBK8
EvolutionaryTrace Q9UBK8
GeneWiki MTRR_(gene)
GenomeRNAi 4552
NextBio 17541
PRO PR:Q9UBK8
Proteomes UP000005640
Bgee Q9UBK8
CleanEx HS_MTRR
ExpressionAtlas Q9UBK8
Genevestigator Q9UBK8
GO GO:0005737
GO:0005829
GO:0045111
GO:0005634
GO:0030586
GO:0050660
GO:0010181
GO:0005506
GO:0050661
GO:0016709
GO:0016723
GO:0034641
GO:0009235
GO:0006306
GO:0046655
GO:0009086
GO:0006555
GO:0032259
GO:0055114
GO:0044281
GO:0000096
GO:0006766
GO:0006767
GO:0006805
Gene3D 1.20.990.10
3.40.50.360
InterPro IPR003097
IPR017927
IPR001094
IPR008254
IPR001709
IPR029039
IPR023173
IPR001433
IPR017938
Pfam PF00667
PF00258
PF00175
PRINTS PR00369
PR00371
SUPFAM SSF52218
SSF63380
PROSITE PS51384
PS50902

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0033353

S-adenosylmethionine cycle

PMID:17369066[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8C1A3

P

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070402

NADPH binding

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003958

NADPH-hemoprotein reductase activity

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030586

[methionine synthase] reductase activity

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043418

homocysteine catabolic process

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904042

negative regulation of cystathionine beta-synthase activity

PMID:24416422[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046655

folic acid metabolic process

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0071949

FAD binding

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

PMID:11466310[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050444

aquacobalamin reductase (NADPH) activity

PMID:16769880[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:17892308[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046655

folic acid metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8C1A3

P

Seeded From UniProt

complete

enables

GO:0016723

oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

PMID:17892308[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006306

DNA methylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8C1A3

P

Seeded From UniProt

complete

involved_in

GO:0050667

homocysteine metabolic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891037
PANTHER:PTN001834647

P

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10191
MGI:MGI:97361
PANTHER:PTN000453956
RGD:3184
RGD:68335
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:Q9UBK8
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

enables

GO:0030586

[methionine synthase] reductase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891037
PANTHER:PTN001834647
UniProtKB:Q9UBK8

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97744
PANTHER:PTN000453956
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

GO:0050444

aquacobalamin reductase (NADPH) activity

PMID:16769880[4]

ECO:0000314

F

Figure 5: used differential molecular extinction coefficient of aqCbl to cob(II)alamin at 525 nm in the presence of hMSR

complete
CACAO 6879

enables

GO:0010181

FMN binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10191
MGI:MGI:97361
PANTHER:PTN000453956
RGD:3184
RGD:68335
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:Q9UBK8
UniProtKB:Q9UHB4

F

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891037
PANTHER:PTN001834647
UniProtKB:Q9UBK8

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453956
RGD:3184
RGD:3185
RGD:3186
UniProtKB:P35228
UniProtKB:Q9SB48
UniProtKB:Q9UHB4

C

Seeded From UniProt

complete

enables

GO:0003958

NADPH-hemoprotein reductase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000453763
PomBase:SPBC29A10.01
RGD:68335
SGD:S000001084
TAIR:locus:2128951
UniProtKB:A0A1D8PLR7
UniProtKB:O08336
UniProtKB:O08394
UniProtKB:P16435
UniProtKB:Q9UBK8

F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001094
InterPro:IPR008254

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001433
InterPro:IPR001709
InterPro:IPR003097
InterPro:IPR017927
InterPro:IPR023173

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001094
InterPro:IPR001433
InterPro:IPR001709
InterPro:IPR003097
InterPro:IPR017927
InterPro:IPR023173

P

Seeded From UniProt

complete

enables

GO:0030586

[methionine synthase] reductase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.16.1.8

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:9501215[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:9501215[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:9501215[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030586

[methionine synthase] reductase activity

PMID:17892308[5]
PMID:9501215[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

enables

GO:0010181

FMN binding

PMID:9501215[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006555

methionine metabolic process

PMID:9501215[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9501215[7]
Reactome:R-HSA-3322140
Reactome:R-HSA-3321918
Reactome:R-HSA-3318563
Reactome:R-HSA-3204318
Reactome:R-HSA-3149539
Reactome:R-HSA-3149518
Reactome:R-HSA-174374

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

Reactome:R-HSA-156581

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009235

cobalamin metabolic process

Reactome:R-HSA-196741

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000096

sulfur amino acid metabolic process

Reactome:R-HSA-1614635

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0486

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Elmore, CL et al. (2007) Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol. Genet. Metab. 91 85-97 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Olteanu, H & Banerjee, R (2001) Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation. J. Biol. Chem. 276 35558-63 PubMed GONUTS page
  3. ↑ Gherasim, C et al. (2014) Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase. PLoS ONE 9 e85544 PubMed GONUTS page
  4. ↑ 4.0 4.1 Yamada, K et al. (2006) Human methionine synthase reductase is a molecular chaperone for human methionine synthase. Proc. Natl. Acad. Sci. U.S.A. 103 9476-81 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Wolthers, KR et al. (2007) Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry 46 11833-44 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Leclerc, D et al. (1998) Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc. Natl. Acad. Sci. U.S.A. 95 3059-64 PubMed GONUTS page
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