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HUMAN:MRP5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ABCC5 (synonyms: MRP5)
Protein Name(s) Multidrug resistance-associated protein 5

ATP-binding cassette sub-family C member 5 Multi-specific organic anion transporter C MOAT-C SMRP pABC11

External Links
UniProt O15440
EMBL AF104942
AF146074
AB019002
U83661
AY754874
AY754875
AY754876
AY196484
AC068644
CH471052
CH471052
BC050744
BC140771
BC142719
AB005659
CCDS CCDS33898.1
CCDS43176.1
PIR JC5667
RefSeq NP_001018881.1
NP_005679.2
XP_005247115.1
XP_005247116.1
UniGene Hs.368563
Hs.743953
ProteinModelPortal O15440
SMR O15440
BioGrid 115368
IntAct O15440
STRING 9606.ENSP00000333926
BindingDB O15440
ChEMBL CHEMBL2046258
DrugBank DB00718
DB00770
DB01076
DB00515
DB00917
DB00975
DB00544
DB00143
DB01033
DB01032
DB01045
DB00203
DB01138
DB00495
TCDB 3.A.1.208.15
PhosphoSite O15440
MaxQB O15440
PaxDb O15440
PRIDE O15440
Ensembl ENST00000265586
ENST00000334444
ENST00000382494
ENST00000392579
ENST00000443376
GeneID 10057
KEGG hsa:10057
UCSC uc003fmg.3
uc003fmh.3
uc010hxl.3
uc010hxn.3
CTD 10057
GeneCards GC03M183637
HGNC HGNC:56
HPA HPA052295
MIM 605251
neXtProt NX_O15440
PharmGKB PA395
eggNOG COG1132
GeneTree ENSGT00770000120514
HOGENOM HOG000116132
HOVERGEN HBG108314
InParanoid O15440
KO K05668
OMA PHMQYYA
OrthoDB EOG7MWGW0
PhylomeDB O15440
TreeFam TF105202
Reactome REACT_121301
REACT_15480
ChiTaRS ABCC5
GeneWiki ABCC5
GenomeRNAi 10057
NextBio 37997
PRO PR:O15440
Proteomes UP000005640
Bgee O15440
CleanEx HS_ABCC5
ExpressionAtlas O15440
Genevestigator O15440
GO GO:0005887
GO:0016020
GO:0005886
GO:0005524
GO:0042626
GO:0008514
GO:0005975
GO:0030203
GO:0030213
GO:0030212
GO:0015711
GO:0044281
GO:0055085
GO:0006810
Gene3D 3.40.50.300
InterPro IPR003593
IPR011527
IPR003439
IPR017871
IPR030238
IPR027417
PANTHER PTHR24223:SF196
Pfam PF00664
PF00005
SMART SM00382
SUPFAM SSF52540
SSF90123
PROSITE PS50929
PS00211
PS50893

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0055085

transmembrane transport

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000657997
RGD:3112
SGD:S000002542
TAIR:locus:2061559
UniProtKB:A7KVC2
UniProtKB:Q10RX7

P

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000657997
RGD:71101
TAIR:locus:2061559
UniProtKB:Q9LK64

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352447
PANTHER:PTN000657997
RGD:2366
RGD:3112
RGD:620268
UniProtKB:O15439
UniProtKB:O15440

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:15297306[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR011527
InterPro:IPR017871
InterPro:IPR030238
InterPro:IPR036640

F

Seeded From UniProt

complete

enables

GO:0008514

organic anion transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030238

F

Seeded From UniProt

complete

involved_in

GO:0015711

organic anion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030238

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527
InterPro:IPR030238
InterPro:IPR036640

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR017871

F

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527
InterPro:IPR030238

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:9827529[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008514

organic anion transmembrane transporter activity

PMID:9827529[3]
Reactome:R-HSA-2142859

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9827529[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:9325169[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

Reactome:R-HSA-382556

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030213

hyaluronan biosynthetic process

Reactome:R-HSA-2142850

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2142859
Reactome:R-HSA-1454916

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Jedlitschky, G et al. (2004) The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 104 3603-10 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Belinsky, MG et al. (1998) Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. J. Natl. Cancer Inst. 90 1735-41 PubMed GONUTS page
  4. ↑ Suzuki, T et al. (1997) cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line. Biochem. Biophys. Res. Commun. 238 790-4 PubMed GONUTS page
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