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HUMAN:MO2R1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CD200R1 (synonyms: CD200R, CRTR2, MOX2R, OX2R)
Protein Name(s) Cell surface glycoprotein CD200 receptor 1

CD200 cell surface glycoprotein receptor Cell surface glycoprotein OX2 receptor 1

External Links
UniProt Q8TD46
EMBL AY284975
AF283760
AF497548
AF497549
AF497550
AF495380
AY358910
AK126349
AK293071
AC074044
CH471052
CH471052
BC069661
BC069721
BC069743
BC093890
CCDS CCDS2969.1
CCDS2970.1
CCDS46889.1
CCDS54623.1
RefSeq NP_620161.1
NP_620385.1
NP_620386.1
NP_740750.1
UniGene Hs.309158
ProteinModelPortal Q8TD46
SMR Q8TD46
BioGrid 126281
IntAct Q8TD46
PhosphoSite Q8TD46
DMDM 26006823
PaxDb Q8TD46
PRIDE Q8TD46
DNASU 131450
Ensembl ENST00000308611
ENST00000440122
ENST00000471858
ENST00000490004
GeneID 131450
KEGG hsa:131450
UCSC uc003dzj.1
uc003dzk.1
uc003dzl.1
uc003dzm.1
CTD 131450
GeneCards GC03M112640
HGNC HGNC:24235
MIM 607546
neXtProt NX_Q8TD46
PharmGKB PA134922446
eggNOG NOG25299
GeneTree ENSGT00390000014496
HOVERGEN HBG108141
InParanoid Q8TD46
OrthoDB EOG7RZ5QQ
PhylomeDB Q8TD46
TreeFam TF335960
Reactome REACT_11152
GeneWiki CD200R1
GenomeRNAi 131450
NextBio 82912
PRO PR:Q8TD46
Proteomes UP000005640
Bgee Q8TD46
CleanEx HS_CD200R1
ExpressionAtlas Q8TD46
Genevestigator Q8TD46
GO GO:0005576
GO:0016021
GO:0005886
GO:0043235
GO:0050776
GO:0016032
Gene3D 2.60.40.10
InterPro IPR013162
IPR007110
IPR013783
IPR003599
Pfam PF08205
SMART SM00409
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0150077

regulation of neuroinflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

occurs_in:(UBERON:0001016)

Seeded From UniProt

complete

involved_in

GO:0034113

heterotypic cell-cell adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

  • has_agent:(CL:0000893)
  • has_agent:(CL:0000581)
  • occurs_in:(CL:0000581)
  • occurs_in:(GO:0009986)

Seeded From UniProt

complete

involved_in

GO:0034113

heterotypic cell-cell adhesion

PMID:11260322[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

has_agent:(CL:0000581)

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:19151626[2]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000881)
  • part_of:(UBERON:0002037)|part_of:(CL:0000881)
  • part_of:(UBERON:0002240)|part_of:(CL:0000881)
  • part_of:(UBERON:0002316)|part_of:(CL:0000129)
  • part_of:(UBERON:0002336)

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

C

part_of:(CL:0000581)

Seeded From UniProt

complete

involved_in

GO:2000405

negative regulation of T cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

Seeded From UniProt

complete

involved_in

GO:1905522

negative regulation of macrophage migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

  • occurs_in:(UBERON:0002240)
  • part_of:(GO:0002862)
  • regulates_o_results_in_movement_of:(CL:0000863)

Seeded From UniProt

complete

involved_in

GO:1901215

negative regulation of neuron death

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

  • part_of:(GO:0002862)
  • regulates_o_occurs_in:(CL:0002608)
  • occurs_in:(CL:0000581)

Seeded From UniProt

complete

involved_in

GO:1900165

negative regulation of interleukin-6 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

  • part_of:(GO:0002862)
  • regulates_o_occurs_in:(CL:0000581)
  • occurs_in:(CL:0000581)
  • negatively_regulates:(GO:0070997)

Seeded From UniProt

complete

involved_in

GO:0150079

negative regulation of neuroinflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9ES58

P

occurs_in:(UBERON:0001017)

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1889024
MGI:MGI:1921853
MGI:MGI:3036289
MGI:MGI:3042847
PANTHER:PTN001087295

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1889024
MGI:MGI:1921853
MGI:MGI:3036289
MGI:MGI:3042847
PANTHER:PTN001087295

C

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:23382219[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0038093

Fc receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019763

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040012

F

Seeded From UniProt

complete

involved_in

GO:0150077

regulation of neuroinflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040012

P

Seeded From UniProt

complete

enables

GO:0140081

glycosylated region protein binding

PMID:10981966[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

has_input:(UniProtKB:P41217)

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:10981966[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:12072366[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019763

immunoglobulin receptor activity

PMID:10981966[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

part_of:(CL:0000581)

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

Reactome:R-HSA-198933

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-199154

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Wright, GJ et al. (2001) The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Immunology 102 173-9 PubMed GONUTS page
  2. ↑ Koning, N et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J. Neuropathol. Exp. Neurol. 68 159-67 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Wright, GJ et al. (2000) Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13 233-42 PubMed GONUTS page
  6. ↑ Barclay, AN et al. (2002) CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol. 23 285-90 PubMed GONUTS page
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