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HUMAN:MLP3C

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MAP1LC3C
Protein Name(s) Microtubule-associated proteins 1A/1B light chain 3C

Autophagy-related protein LC3 C Autophagy-related ubiquitin-like modifier LC3 C MAP1 light chain 3-like protein 3 MAP1A/MAP1B light chain 3 C MAP1A/MAP1B LC3 C Microtubule-associated protein 1 light chain 3 gamma

External Links
UniProt Q9BXW4
EMBL AF276659
BX571673
BC127722
BC132986
BC132988
CCDS CCDS31074.1
RefSeq NP_001004343.1
XP_005273196.1
UniGene Hs.534971
PDB 2NCN
3VVW
3WAM
3WAP
5DPW
PDBsum 2NCN
3VVW
3WAM
3WAP
5DPW
ProteinModelPortal Q9BXW4
SMR Q9BXW4
BioGrid 136855
DIP DIP-57020N
ELM Q9BXW4
IntAct Q9BXW4
STRING 9606.ENSP00000349785
BioMuta MAP1LC3C
DMDM 84028113
PaxDb Q9BXW4
PRIDE Q9BXW4
Ensembl ENST00000357246
GeneID 440738
KEGG hsa:440738
UCSC uc001hzk.3
CTD 440738
DisGeNET 440738
EuPathDB HostDB:ENSG00000197769.5
GeneCards MAP1LC3C
HGNC HGNC:13353
HPA HPA072670
MIM 609605
neXtProt NX_Q9BXW4
OpenTargets ENSG00000197769
PharmGKB PA142671482
eggNOG KOG1654
ENOG4111JAT
GeneTree ENSGT00390000012937
HOGENOM HOG000232034
HOVERGEN HBG051706
InParanoid Q9BXW4
KO K10435
OMA TQFVTII
OrthoDB EOG091G18ST
PhylomeDB Q9BXW4
TreeFam TF312964
Reactome R-HSA-1632852
SIGNOR Q9BXW4
GenomeRNAi 440738
PRO PR:Q9BXW4
Proteomes UP000005640
Bgee ENSG00000197769
CleanEx HS_MAP1LC3C
Genevisible Q9BXW4
GO GO:0005776
GO:0000421
GO:0036464
GO:0031410
GO:0005829
GO:0012505
GO:0005874
GO:0031090
GO:0031625
GO:0035973
GO:0000045
GO:0097352
GO:0000422
GO:0006995
GO:0009267
GO:0016236
CDD cd01611
InterPro IPR004241
IPR027731
IPR029071
PANTHER PTHR10969
PTHR10969:SF41
Pfam PF02991
SUPFAM SSF54236

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005776

autophagosome

PMID:28223137[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097352

autophagosome maturation

PMID:28223137[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:28223137[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:28223137[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:25127057[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9C035

F

Seeded From UniProt

complete

involved_in

GO:0035973

aggrephagy

PMID:28404643[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031090

organelle membrane

PMID:12740394[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9H492

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

PMID:12740394[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9H492

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000861056
RGD:621315

F

Seeded From UniProt

complete

involved_in

GO:0006995

cellular response to nitrogen starvation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103522
dictyBase:DDB_G0286191

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103525
RGD:735183
UniProtKB:P60519
UniProtKB:Q9H492

C

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103525
UniProtKB:Q9GZQ8
UniProtKB:Q9H492

P

Seeded From UniProt

complete

part_of

GO:0000421

autophagosome membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1915661
PANTHER:PTN000103525
RGD:621315
RGD:735183
UniProtKB:O95166
UniProtKB:P60520
WB:WBGene00002980
WB:WBGene00002981

C

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000103525
RGD:735183
UniProtKB:Q9H492

P

Seeded From UniProt

complete

part_of

GO:0036464

cytoplasmic ribonucleoprotein granule

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027731

P

Seeded From UniProt

complete

involved_in

GO:0097352

autophagosome maturation

Reactome:R-HSA-5682388

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5683593
Reactome:R-HSA-5682896
Reactome:R-HSA-5682388
Reactome:R-HSA-5682377
Reactome:R-HSA-5682011
Reactome:R-HSA-5681987
Reactome:R-HSA-5681981
Reactome:R-HSA-5678490

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0000421

autophagosome membrane

Reactome:R-HSA-5682388

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

part_of

GO:0000421

autophagosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0022

C

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0147

C

Seeded From UniProt

complete

GO:0032527

protein exit from endoplasmic reticulum

PMID:26431026[6]

ECO:0000315

P

Immunofluorescence was employed to target the export of MAN2A1-SFB-GFP from the ER to the Golgi upon knockdown of MAP1LC3C. Results as shown in Fig 6E show significant reduction of ER export of MAN2A1-SFB-GFP.

complete
CACAO 13066

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Tam, RC et al. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Exp. Cell Res. 352 304-312 PubMed GONUTS page
  2. ↑ Mandell, MA et al. (2014) TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev. Cell 30 394-409 PubMed GONUTS page
  3. ↑ Liu, X et al. (2017) The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J. Cell Biol. 216 1301-1320 PubMed GONUTS page
  4. ↑ 4.0 4.1 He, H et al. (2003) Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J. Biol. Chem. 278 29278-87 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Stadel, D et al. (2015) TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export. Mol. Cell 60 89-104 PubMed GONUTS page
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