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HUMAN:MIPT3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRAF3IP1 (synonyms: IFT54, MIPT3)
Protein Name(s) TRAF3-interacting protein 1

Interleukin-13 receptor alpha 1-binding protein 1 Intraflagellar transport protein 54 homolog Microtubule-interacting protein associated with TRAF3 MIP-T3

External Links
UniProt Q8TDR0
EMBL AF230877
AF242456
AC012485
CH471063
BC059174
AL080153
CCDS CCDS33415.1
CCDS46557.1
PIR T12536
RefSeq NP_001132962.1
NP_056465.2
UniGene Hs.631898
PDB 2EQO
PDBsum 2EQO
ProteinModelPortal Q8TDR0
SMR Q8TDR0
BioGrid 117577
IntAct Q8TDR0
STRING 9606.ENSP00000362424
PhosphoSite Q8TDR0
DMDM 74727348
MaxQB Q8TDR0
PaxDb Q8TDR0
PRIDE Q8TDR0
Ensembl ENST00000373327
ENST00000391993
GeneID 26146
KEGG hsa:26146
UCSC uc002vye.3
uc002vyf.3
CTD 26146
GeneCards GC02P239229
HGNC HGNC:17861
HPA HPA037857
HPA037858
MIM 607380
neXtProt NX_Q8TDR0
PharmGKB PA134943602
eggNOG NOG304934
GeneTree ENSGT00720000108822
HOGENOM HOG000007159
HOVERGEN HBG101388
InParanoid Q8TDR0
OMA NGEHSRD
OrthoDB EOG7BKCV3
PhylomeDB Q8TDR0
TreeFam TF315473
ChiTaRS TRAF3IP1
EvolutionaryTrace Q8TDR0
GenomeRNAi 26146
NextBio 48201
PRO PR:Q8TDR0
Proteomes UP000005640
Bgee Q8TDR0
CleanEx HS_TRAF3IP1
ExpressionAtlas Q8TDR0
Genevestigator Q8TDR0
GO GO:0005930
GO:0005813
GO:0036064
GO:0005929
GO:0030992
GO:0042384
GO:0031076
GO:0042733
GO:0035050
GO:0042073
GO:0050687
GO:0032688
GO:1901621
GO:0021532
GO:0036342
InterPro IPR018799
PANTHER PTHR31363

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050687

negative regulation of defense response to virus

PMID:22079989[1]

ECO:0000315

P

Fig. 7ABC

complete
CACAO 3043

GO:0001933

negative regulation of protein phosphorylation

PMID:22079989[1]

ECO:0000315

P

Fig. 6

complete
CACAO 3044

GO:0032480

negative regulation of type I interferon production

PMID:22079989[1]

ECO:0000315

P

Fig. 1

complete
CACAO 3045

GO:0031333

negative regulation of protein complex assembly

PMID:22079989[1]

ECO:0000315

P

Fig. 4(A-D), and Fig. 5

complete
CACAO 3046

part_of

GO:0097546

ciliary base

PMID:26487268[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097542

ciliary tip

PMID:26487268[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035869

ciliary transition zone

PMID:26487268[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070507

regulation of microtubule cytoskeleton organization

PMID:26487268[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001738

morphogenesis of a polarized epithelium

PMID:26487268[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:26487268[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031333

negative regulation of protein complex assembly

PMID:22079989[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032480

negative regulation of type I interferon production

PMID:22079989[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

PMID:22079989[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050687

negative regulation of defense response to virus

PMID:22079989[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q149C2

C

Seeded From UniProt

complete

involved_in

GO:0042073

intraciliary transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000773545
WB:WBGene00001127

P

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921269
PANTHER:PTN000773545
WB:WBGene00001127

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921269
PANTHER:PTN000773545

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921269
PANTHER:PTN000773545

C

Seeded From UniProt

complete

involved_in

GO:1901621

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0070507

regulation of microtubule cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0050687

negative regulation of defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0042733

embryonic digit morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0036342

post-anal tail morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

C

Seeded From UniProt

complete

involved_in

GO:0035050

embryonic heart tube development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0032688

negative regulation of interferon-beta production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

involved_in

GO:0031076

embryonic camera-type eye development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

C

Seeded From UniProt

complete

involved_in

GO:0021532

neural tube patterning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

C

Seeded From UniProt

complete

involved_in

GO:0001738

morphogenesis of a polarized epithelium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q149C2
ensembl:ENSMUSP00000042391

P

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018799

F

Seeded From UniProt

complete

part_of

GO:0097542

ciliary tip

Reactome:R-HSA-5625426
Reactome:R-HSA-5625421
Reactome:R-HSA-5625416
Reactome:R-HSA-5624952

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

Reactome:R-HSA-5620924

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

Reactome:R-HSA-5625426
Reactome:R-HSA-5625424
Reactome:R-HSA-5625416
Reactome:R-HSA-5624949

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969
UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ng, MH et al. (2011) MIP-T3 is a negative regulator of innate type I IFN response. J. Immunol. 187 6473-82 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Bizet, AA et al. (2015) Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Commun 6 8666 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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