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HUMAN:MINP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MINPP1 (synonyms: MIPP)
Protein Name(s) Multiple inositol polyphosphate phosphatase 1

2,3-bisphosphoglycerate 3-phosphatase 2,3-BPG phosphatase Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase Ins(1,3,4,5)P(4) 3-phosphatase

External Links
UniProt Q9UNW1
EMBL AF084943
AF084944
AF046914
AL050356
AY358938
AK309176
AB209819
AL355334
AL138767
AL138767
AL355334
AL355334
AL138767
AL138767
AL355334
BC032504
CCDS CCDS53551.1
CCDS53552.1
CCDS7384.1
RefSeq NP_001171588.1
NP_001171589.1
NP_004888.2
UniGene Hs.121260
ProteinModelPortal Q9UNW1
SMR Q9UNW1
BioGrid 114932
STRING 9606.ENSP00000361064
DEPOD Q9UNW1
PhosphoSite Q9UNW1
DMDM 68565617
MaxQB Q9UNW1
PaxDb Q9UNW1
PeptideAtlas Q9UNW1
PRIDE Q9UNW1
DNASU 9562
Ensembl ENST00000371994
ENST00000371996
ENST00000536010
GeneID 9562
KEGG hsa:9562
UCSC uc001keu.3
uc001kev.3
CTD 9562
GeneCards GC10P089264
HGNC HGNC:7102
HPA HPA026859
MIM 605391
neXtProt NX_Q9UNW1
PharmGKB PA30820
eggNOG NOG260296
GeneTree ENSGT00390000018409
HOGENOM HOG000113591
HOVERGEN HBG052872
InParanoid Q9UNW1
KO K03103
OMA FKEECEL
OrthoDB EOG7992QC
PhylomeDB Q9UNW1
TreeFam TF324072
BioCyc MetaCyc:HS03025-MONOMER
BRENDA 3.1.3.62
Reactome REACT_150253
SABIO-RK Q9UNW1
ChiTaRS MINPP1
GeneWiki MINPP1
GenomeRNAi 9562
NextBio 35863
PRO PR:Q9UNW1
Proteomes UP000005640
Bgee Q9UNW1
CleanEx HS_MINPP1
ExpressionAtlas Q9UNW1
Genevestigator Q9UNW1
GO GO:0005783
GO:0005788
GO:0070062
GO:0003993
GO:0034417
GO:0052826
GO:0008969
GO:0030282
GO:0016311
GO:0043647
GO:0001503
GO:0006797
GO:0044281
Gene3D 3.40.50.1240
InterPro IPR000560
IPR029033
IPR016274
Pfam PF00328
PIRSF PIRSF000894
SUPFAM SSF53254
PROSITE PS00014

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0034417

bisphosphoglycerate 3-phosphatase activity

PMID:18413611[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030282

bone mineralization

PMID:9923613[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0052745

inositol phosphate phosphatase activity

PMID:9923613[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

PMID:9923613[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0052745

inositol phosphate phosphatase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026061
PANTHER:PTN000469221

F

Seeded From UniProt

complete

enables

GO:0003993

acid phosphatase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001076439
PomBase:SPBC428.03c
PomBase:SPBP4G3.02
SGD:S000000094
SGD:S000000296
SGD:S000000297
SGD:S000001258
UniProtKB:Q5AMR2

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0101006

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016791

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0052745

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030351

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051717

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0052826

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0034417

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0052745

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003993

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0052826

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0034417

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016274

F

Seeded From UniProt

complete

enables

GO:0034417

bisphosphoglycerate 3-phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.80

F

Seeded From UniProt

complete

enables

GO:0052826

inositol hexakisphosphate 2-phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.62

F

Seeded From UniProt

complete

enables

GO:0004446

inositol-hexakisphosphate phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.62

F

Seeded From UniProt

complete

enables

GO:0101006

protein histidine phosphatase activity

PMID:10087200[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006797

polyphosphate metabolic process

PMID:10087200[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:10087200[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0052826

inositol hexakisphosphate 2-phosphatase activity

Reactome:R-HSA-1855225

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051717

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

Reactome:R-HSA-1855200

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043647

inositol phosphate metabolic process

Reactome:R-HSA-1855231

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030351

inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity

Reactome:R-HSA-1855163

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-1855225
Reactome:R-HSA-1855200
Reactome:R-HSA-1855163

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0096

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. Cho, J et al. (2008) Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. U.S.A. 105 5998-6003 PubMed GONUTS page
  3. 3.0 3.1 3.2 Caffrey, JJ et al. (1999) The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. FEBS Lett. 442 99-104 PubMed GONUTS page
  4. 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. 5.0 5.1 5.2 Chi, H et al. (1999) Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics 56 324-36 PubMed GONUTS page