HUMAN:MICU1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MICU1 (synonyms: CALC, CBARA1)
Protein Name(s)	Calcium uptake protein 1, mitochondrial Atopy-related autoantigen CALC ara CALC Calcium-binding atopy-related autoantigen 1
External Links
UniProt	Q9BPX6
EMBL	AK023318 AK296086 AK298347 AL117423 AL513185 AC091769 AL356009 CH471083 BC004190 BC004216 BC016641 AK022697 Y17711
CCDS	CCDS55714.1 CCDS55715.1
PIR	T17225
RefSeq	NP_001182447.1 NP_001182448.1 NP_006068.2
UniGene	Hs.524367
PDB	4NSC 4NSD
PDBsum	4NSC 4NSD
ProteinModelPortal	Q9BPX6
SMR	Q9BPX6
BioGrid	115646
DIP	DIP-53438N
IntAct	Q9BPX6
STRING	9606.ENSP00000381748
Allergome	3325 414
TCDB	8.A.44.1.1
PhosphoSite	Q9BPX6
DMDM	74761192
MaxQB	Q9BPX6
PaxDb	Q9BPX6
PRIDE	Q9BPX6
DNASU	10367
Ensembl	ENST00000361114 ENST00000398763 ENST00000418483
GeneID	10367
KEGG	hsa:10367
UCSC	uc001jtb.2 uc010qjw.2 uc010qjx.2
CTD	10367
GeneCards	GC10M074128
HGNC	HGNC:1530
HPA	HPA037480
MIM	605084 615673
neXtProt	NX_Q9BPX6
Orphanet	401768
PharmGKB	PA26110
eggNOG	NOG327412
GeneTree	ENSGT00530000063089
HOVERGEN	HBG107586
InParanoid	Q9BPX6
PhylomeDB	Q9BPX6
TreeFam	TF313815
GeneWiki	CBARA1
GenomeRNAi	10367
NextBio	39295
PRO	PR:Q9BPX6
Proteomes	UP000005640
Bgee	Q9BPX6
CleanEx	HS_CBARA1
ExpressionAtlas	Q9BPX6
Genevestigator	Q9BPX6
GO	GO:0034704 GO:0032592 GO:0005622 GO:0005743 GO:0005758 GO:1990246 GO:0005509 GO:0042802 GO:0046982 GO:0070509 GO:0036444 GO:0006952 GO:0051560 GO:0006851 GO:0051561 GO:0051260
Gene3D	1.10.238.10
InterPro	IPR011992 IPR018247 IPR002048
Pfam	PF13202
SMART	SM00054
PROSITE	PS00018 PS50222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1900069	regulation of cellular hyperosmotic salinity response	PMID:26975899^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051561	positive regulation of mitochondrial calcium ion concentration	PMID:26975899^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:26387864^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IYU8	F	Seeded From UniProt	complete
involved_in	GO:0051560	mitochondrial calcium ion homeostasis	PMID:26903221^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036444	calcium import into the mitochondrion	PMID:26903221^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006851	mitochondrial calcium ion transmembrane transport	PMID:27099988^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051560	mitochondrial calcium ion homeostasis	PMID:27099988^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:27099988^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990246	uniplex complex	PMID:24560927^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990246	uniplex complex	PMID:24231807^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:20693986^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051561	positive regulation of mitochondrial calcium ion concentration	PMID:24560927^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051560	mitochondrial calcium ion homeostasis	PMID:23101630^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051560	mitochondrial calcium ion homeostasis	PMID:20693986^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:24514027^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:24560927^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IYU8	F	Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VCX5	C	Seeded From UniProt	complete
part_of	GO:0032592	integral component of mitochondrial membrane	PMID:23101630^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006851	mitochondrial calcium ion transmembrane transport	PMID:23101630^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006851	mitochondrial calcium ion transmembrane transport	PMID:24560927^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:24560927^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:24231807^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:20693986^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:24514027^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:23101630^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:1990246	uniplex complex	PMID:22925203^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0036444	calcium import into the mitochondrion	PMID:22925203^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24514027^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BPX6	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048 InterPro:IPR039800	F	Seeded From UniProt	complete
involved_in	GO:0006851	mitochondrial calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039800	P	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:26975899^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:26975899^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:9806765^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005622	intracellular	PMID:9806765^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006851	mitochondrial calcium ion transmembrane transport	Reactome:R-HSA-8949215	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	Reactome:R-HSA-8953461 Reactome:R-HSA-8949178	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0169	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hou, T et al. (2016) Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation. Cell Calcium 59 262-70 PubMed GONUTS page
↑ Petrungaro, C et al. (2015) The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake. Cell Metab. 22 721-33 PubMed GONUTS page
↑ ^3.0 ^3.1 Matesanz-Isabel, J et al. (2016) Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. Biochim. Biophys. Acta 1858 1110-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Tsai, MF et al. (2016) Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife 5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Patron, M et al. (2014) MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol. Cell 53 726-37 PubMed GONUTS page
↑ ^6.0 ^6.1 Sancak, Y et al. (2013) EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 342 1379-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Perocchi, F et al. (2010) MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature 467 291-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Mallilankaraman, K et al. (2012) MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell 151 630-44 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Wang, L et al. (2014) Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. EMBO J. 33 594-604 PubMed GONUTS page
↑ ^10.0 ^10.1 Tsai, LC et al. (2012) Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 11 837-47 PubMed GONUTS page
↑ ^11.0 ^11.1 Natter, S et al. (1998) Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J. 12 1559-69 PubMed GONUTS page

[PMID:26975899-1] 1.0 ^1.1 ^1.2 ^1.3 Hou, T et al. (2016) Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation. Cell Calcium 59 262-70 PubMed GONUTS page

[PMID:26387864-2] Petrungaro, C et al. (2015) The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake. Cell Metab. 22 721-33 PubMed GONUTS page

[PMID:26903221-3] 3.0 ^3.1 Matesanz-Isabel, J et al. (2016) Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. Biochim. Biophys. Acta 1858 1110-7 PubMed GONUTS page

[PMID:27099988-4] 4.0 ^4.1 ^4.2 Tsai, MF et al. (2016) Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife 5 PubMed GONUTS page

[PMID:24560927-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Patron, M et al. (2014) MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol. Cell 53 726-37 PubMed GONUTS page

[PMID:24231807-6] 6.0 ^6.1 Sancak, Y et al. (2013) EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 342 1379-82 PubMed GONUTS page

[PMID:20693986-7] 7.0 ^7.1 ^7.2 Perocchi, F et al. (2010) MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature 467 291-6 PubMed GONUTS page

[PMID:23101630-8] 8.0 ^8.1 ^8.2 ^8.3 Mallilankaraman, K et al. (2012) MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell 151 630-44 PubMed GONUTS page

[PMID:24514027-9] 9.0 ^9.1 ^9.2 Wang, L et al. (2014) Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. EMBO J. 33 594-604 PubMed GONUTS page

[PMID:22925203-10] 10.0 ^10.1 Tsai, LC et al. (2012) Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 11 837-47 PubMed GONUTS page

[PMID:9806765-11] 11.0 ^11.1 Natter, S et al. (1998) Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J. 12 1559-69 PubMed GONUTS page

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HUMAN:MICU1

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