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HUMAN:MIB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MIB1 (synonyms: DIP1, KIAA1323, ZZANK2)
Protein Name(s) E3 ubiquitin-protein ligase MIB1

DAPK-interacting protein 1 DIP-1 Mind bomb homolog 1 RING-type E3 ubiquitin transferase MIB1 (ECO:0000305) Zinc finger ZZ type with ankyrin repeat domain protein 2

External Links
UniProt Q86YT6
EMBL AY149908
AY147849
EF444995
BC022403
BC110581
BC110582
CR749635
AL713705
AB037744
AK075157
CCDS CCDS11871.1
RefSeq NP_065825.1
UniGene Hs.140903
PDB 4TSE
4XI6
4XI7
4XIB
PDBsum 4TSE
4XI6
4XI7
4XIB
ProteinModelPortal Q86YT6
SMR Q86YT6
BioGrid 121593
IntAct Q86YT6
MINT MINT-2841371
STRING 9606.ENSP00000261537
iPTMnet Q86YT6
PhosphoSitePlus Q86YT6
DMDM 68565512
EPD Q86YT6
MaxQB Q86YT6
PaxDb Q86YT6
PeptideAtlas Q86YT6
PRIDE Q86YT6
Ensembl ENST00000261537
GeneID 57534
KEGG hsa:57534
UCSC uc002ktq.5
CTD 57534
DisGeNET 57534
EuPathDB HostDB:ENSG00000101752.11
GeneCards MIB1
HGNC HGNC:21086
HPA CAB037044
HPA019100
MalaCards MIB1
MIM 608677
615092
neXtProt NX_Q86YT6
OpenTargets ENSG00000101752
Orphanet 54260
PharmGKB PA134862722
eggNOG KOG0504
KOG4582
COG0666
GeneTree ENSGT00900000141005
HOVERGEN HBG068386
InParanoid Q86YT6
KO K10645
OMA CYNERKT
OrthoDB EOG091G00Z0
PhylomeDB Q86YT6
TreeFam TF324147
Reactome [www.reactome.org/content/detail/R-HSA-2122948 R-HSA-2122948]
[www.reactome.org/content/detail/R-HSA-2644606 R-HSA-2644606]
[www.reactome.org/content/detail/R-HSA-2691232 R-HSA-2691232]
[www.reactome.org/content/detail/R-HSA-2894862 R-HSA-2894862]
[www.reactome.org/content/detail/R-HSA-2979096 R-HSA-2979096]
SignaLink Q86YT6
SIGNOR Q86YT6
UniPathway UPA00143
ChiTaRS MIB1
GeneWiki MIB1_(gene)
GenomeRNAi 57534
PRO PR:Q86YT6
Proteomes UP000005640
Bgee ENSG00000101752
CleanEx HS_MIB1
Genevisible Q86YT6
GO GO:0005813
GO:0005737
GO:0031410
GO:0005829
GO:0005886
GO:0014069
GO:0004842
GO:0008270
GO:0001568
GO:0006897
GO:0001947
GO:0001701
GO:0045665
GO:0001841
GO:0007219
GO:0045807
GO:0001756
CDD cd00204
Gene3D 1.25.40.20
3.30.40.10
InterPro IPR002110
IPR020683
IPR036770
IPR010606
IPR001841
IPR013083
IPR000433
Pfam PF12796
PF06701
PF00569
PRINTS PR01415
SMART SM00248
SM00184
SM00291
SUPFAM SSF48403
PROSITE PS50297
PS50088
PS51416
PS50089
PS01357
PS50135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005813

centrosome

PMID:21399614[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2679684
PANTHER:PTN001197468

P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263601
MGI:MGI:2443157
PANTHER:PTN000653843

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263601
PANTHER:PTN000653843

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0086442
FB:FBgn0263601
PANTHER:PTN001197468

C

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001197468
UniProtKB:Q96AX9
ZFIN:ZDB-GENE-030404-2

F

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZUV2
ensembl:ENSRNOP00000018025

C

Seeded From UniProt

complete

involved_in

GO:0045807

positive regulation of endocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0045665

negative regulation of neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:23615451[3]

ECO:0000314

direct assay evidence used in manual assertion

P

The organism is H. Sapiens and the protein is MIB1 (E3 ubiquitin-protein ligase MIB1).. Fig 1C confirms the ubiquitination of SMN by MIB1. Fig 1D: "We found that overexpressing wild-type Mib1 decreased the half-life of newly synthesized radiolabeled SMN by half, from ∼4 to 2 h, compared with the active-site Mib1 mutant." 

Figure 2A shows that this ubiquitination lowers the half life of SMN by targeting it for proteasomal degradation

complete
CACAO 13044

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

C

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0001841

neural tube formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0001756

somitogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

involved_in

GO:0001568

blood vessel development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q80SY4
ensembl:ENSMUSP00000054428

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606
InterPro:IPR037252

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000433

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606
InterPro:IPR037252

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-2900765
Reactome:R-HSA-2769007
Reactome:R-HSA-2737728

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Kwon, DY et al. (2013) The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Mol. Biol. Cell 24 1863-71 PubMed GONUTS page
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