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HUMAN:MGA
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MGAM (synonyms: MGA, MGAML) | |
| Protein Name(s) | Maltase-glucoamylase, intestinal
Maltase Alpha-glucosidase Glucoamylase Glucan 1,4-alpha-glucosidase | |
| External Links | ||
| UniProt | O43451 | |
| EMBL | AF016833 AC091684 AC073647 AC091742 BC120872 | |
| CCDS | CCDS47727.1 | |
| RefSeq | NP_004659.2 | |
| UniGene | Hs.122785 | |
| PDB | 2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP | |
| PDBsum | 2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP | |
| ProteinModelPortal | O43451 | |
| SMR | O43451 | |
| BioGrid | 114462 | |
| IntAct | O43451 | |
| STRING | 9606.ENSP00000373973 | |
| BindingDB | O43451 | |
| ChEMBL | CHEMBL2074 | |
| DrugBank | DB00284 DB00491 DB04878 | |
| GuidetoPHARMACOLOGY | 2627 | |
| CAZy | GH31 | |
| PhosphoSite | O43451 | |
| PaxDb | O43451 | |
| PRIDE | O43451 | |
| Ensembl | ENST00000549489 ENST00000620571 | |
| GeneID | 8972 | |
| KEGG | hsa:8972 | |
| UCSC | uc003vwy.3 | |
| CTD | 8972 | |
| GeneCards | GC07P141607 | |
| H-InvDB | HIX0025263 | |
| HGNC | HGNC:7043 | |
| HPA | HPA002270 | |
| MIM | 154360 | |
| neXtProt | NX_O43451 | |
| PharmGKB | PA30778 | |
| eggNOG | COG1501 | |
| GeneTree | ENSGT00760000119229 | |
| HOGENOM | HOG000067936 | |
| HOVERGEN | HBG080721 | |
| InParanoid | O43451 | |
| KO | K12047 | |
| PhylomeDB | O43451 | |
| TreeFam | TF314577 | |
| Reactome | REACT_9472 | |
| EvolutionaryTrace | O43451 | |
| GeneWiki | Maltase-glucoamylase | |
| GenomeRNAi | 8972 | |
| NextBio | 33667 | |
| PRO | PR:O43451 | |
| Proteomes | UP000005640 | |
| Bgee | O43451 | |
| CleanEx | HS_MGA HS_MGAM | |
| ExpressionAtlas | O43451 | |
| Genevestigator | O43451 | |
| GO | GO:0016324 GO:0070062 GO:0016021 GO:0005886 GO:0004558 GO:0016160 GO:0030246 GO:0003824 GO:0004339 GO:0032450 GO:0005975 GO:0044245 GO:0044281 GO:0005983 | |
| Gene3D | 4.10.110.10 | |
| InterPro | IPR011013 IPR000322 IPR017853 IPR000519 IPR017957 | |
| Pfam | PF01055 PF00088 | |
| SMART | SM00018 | |
| SUPFAM | SSF51445 SSF74650 | |
| PROSITE | PS00129 PS00707 PS00025 PS51448 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004558 |
alpha-1,4-glucosidase activity |
ECO:0000314 |
F |
Degradation of maltose: made more stable and catalytic via immobilization using agar |
complete | |||||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000023 |
maltose metabolic process |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0032450 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016160 |
amylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5THE2 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004558 |
alpha-1,4-glucosidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B5THE2 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004553 |
hydrolase activity, hydrolyzing O-glycosyl compounds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032450 |
maltose alpha-glucosidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004339 |
glucan 1,4-alpha-glucosidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090599 |
alpha-glucosidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004558 |
alpha-1,4-glucosidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005983 |
starch catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0101003 |
ficolin-1-rich granule membrane |
Reactome:R-HSA-6800426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070821 |
tertiary granule membrane |
Reactome:R-HSA-6798747 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044245 |
polysaccharide digestion |
Reactome:R-HSA-189085 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-6800426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Nawaz, MA et al. (2015) Continuous degradation of maltose: improvement in stability and catalytic properties of maltase (α-glucosidase) through immobilization using agar-agar gel as a support. Bioprocess Biosyst Eng 38 631-8 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 3.0 3.1 Nichols, BL et al. (1998) Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. J. Biol. Chem. 273 3076-81 PubMed GONUTS page
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