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HUMAN:METH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MTR
Protein Name(s) Methionine synthase

5-methyltetrahydrofolate--homocysteine methyltransferase Vitamin-B12 dependent methionine synthase MS

External Links
UniProt Q99707
EMBL U71285
U75743
U73338
AL359185
AL359259
AL359259
AL359185
CH471098
BC130616
BC136440
BC144095
CCDS CCDS1614.1
RefSeq NP_000245.2
NP_001278869.1
UniGene Hs.498187
PDB 2O2K
4CCZ
PDBsum 2O2K
4CCZ
ProteinModelPortal Q99707
SMR Q99707
BioGrid 110642
IntAct Q99707
STRING 9606.ENSP00000355536
BindingDB Q99707
ChEMBL CHEMBL2150844
DrugBank DB00115
DB00200
DB00134
DB00116
PhosphoSite Q99707
DMDM 2842762
MaxQB Q99707
PaxDb Q99707
PRIDE Q99707
Ensembl ENST00000366577
GeneID 4548
KEGG hsa:4548
UCSC uc001hyi.4
CTD 4548
GeneCards GC01P236958
GeneReviews MTR
HGNC HGNC:7468
HPA HPA044474
MIM 156570
250940
601634
603174
neXtProt NX_Q99707
Orphanet 2170
PharmGKB PA31272
eggNOG COG1410
GeneTree ENSGT00420000029824
HOGENOM HOG000251409
HOVERGEN HBG006347
InParanoid Q99707
KO K00548
OMA DYNSIMV
OrthoDB EOG7TF786
PhylomeDB Q99707
TreeFam TF312829
BioCyc MetaCyc:HS04076-MONOMER
Reactome REACT_115639
REACT_163862
REACT_169149
REACT_169439
REACT_6946
UniPathway UPA00051
ChiTaRS MTR
EvolutionaryTrace Q99707
GeneWiki Methionine_synthase
GenomeRNAi 4548
NextBio 17533
PRO PR:Q99707
Proteomes UP000005640
Bgee Q99707
CleanEx HS_MTR
ExpressionAtlas Q99707
Genevestigator Q99707
GO GO:0005829
GO:0031419
GO:0008705
GO:0008898
GO:0008270
GO:0034641
GO:0009235
GO:0032259
GO:0007399
GO:0042558
GO:0044281
GO:0000096
GO:0006766
GO:0006767
GO:0006805
Gene3D 1.10.1240.10
3.10.196.10
3.20.20.20
3.20.20.330
3.40.50.280
InterPro IPR003759
IPR006158
IPR011005
IPR011822
IPR000489
IPR003726
IPR004223
Pfam PF02310
PF02607
PF02965
PF00809
PF02574
PIRSF PIRSF000381
SMART SM01018
SUPFAM SSF47644
SSF51717
SSF52242
SSF56507
SSF82282
TIGRFAMs TIGR02082
PROSITE PS50974
PS51332
PS51337
PS50970
PS50972

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008705

methionine synthase activity

PMID:16769880[1]

ECO:0000314

F

Figure 2: shows methionine formed by hMS in the presence of increasing concentrations of hMSR

complete
CACAO 6995

involved_in

GO:0071732

cellular response to nitric oxide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:G3V8A4

P

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:G3V8A4

P

Seeded From UniProt

complete

involved_in

GO:0031103

axon regeneration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:G3V8A4

P

part_of:(GO:0048678)

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

PMID:23825108[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

PMID:23825108[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002620)

Seeded From UniProt

complete

involved_in

GO:0009235

cobalamin metabolic process

PMID:23825108[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002620)

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

PMID:16769880[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10587
MGI:MGI:894292
PANTHER:PTN001464934
RGD:621283
UniProtKB:Q99707

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10587
PANTHER:PTN001464934
UniProtKB:O33259
UniProtKB:Q99707

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A6H5Y3
ensembl:ENSMUSP00000097442

P

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A6H5Y3
ensembl:ENSMUSP00000097442

F

Seeded From UniProt

complete

involved_in

GO:0071732

cellular response to nitric oxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V8A4
ensembl:ENSRNOP00000023973

P

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V8A4
ensembl:ENSRNOP00000023973

P

Seeded From UniProt

complete

involved_in

GO:0031103

axon regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V8A4
ensembl:ENSRNOP00000023973

P

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V8A4
ensembl:ENSRNOP00000023973

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011822

F

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004223
InterPro:IPR011822
InterPro:IPR037010

F

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004223
InterPro:IPR011822
InterPro:IPR037010

P

Seeded From UniProt

complete

enables

GO:0031419

cobalamin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006158
InterPro:IPR011822
InterPro:IPR033706
InterPro:IPR036724

F

Seeded From UniProt

complete

involved_in

GO:0042558

pteridine-containing compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000489

P

Seeded From UniProt

complete

involved_in

GO:0044237

cellular metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011005

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006158
InterPro:IPR036724

F

Seeded From UniProt

complete

enables

GO:0008705

methionine synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.13

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:8968737[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

Reactome:R-HSA-156581

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009235

cobalamin metabolic process

Reactome:R-HSA-196741

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-3322140
Reactome:R-HSA-3321918
Reactome:R-HSA-3318563
Reactome:R-HSA-3204318
Reactome:R-HSA-3149539
Reactome:R-HSA-3149518
Reactome:R-HSA-174374

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0000096

sulfur amino acid metabolic process

Reactome:R-HSA-1614635

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0031419

cobalamin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0846

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0486

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Yamada, K et al. (2006) Human methionine synthase reductase is a molecular chaperone for human methionine synthase. Proc. Natl. Acad. Sci. U.S.A. 103 9476-81 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Fofou-Caillierez, MB et al. (2013) Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia. Hum. Mol. Genet. 22 4591-601 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Leclerc, D et al. (1996) Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum. Mol. Genet. 5 1867-74 PubMed GONUTS page
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