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HUMAN:MAP4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MAP4
Protein Name(s) Microtubule-associated protein 4

MAP-4

External Links
UniProt P27816
EMBL M64571
U19727
AK054696
AK125245
AB209377
AC124916
AC139667
CH471055
BC008715
BC012794
BC015149
BC051843
CR749544
CCDS CCDS33750.1
CCDS46818.1
CCDS46821.1
PIR A41206
RefSeq NP_001127836.1
NP_002366.2
NP_112147.2
UniGene Hs.517949
ProteinModelPortal P27816
BioGrid 110306
IntAct P27816
MINT MINT-1425668
STRING 9606.ENSP00000353375
DrugBank DB01248
DB01229
PhosphoSite P27816
DMDM 269849673
MaxQB P27816
PaxDb P27816
PRIDE P27816
DNASU 4134
Ensembl ENST00000360240
ENST00000395734
ENST00000434267
ENST00000439356
GeneID 4134
KEGG hsa:4134
UCSC uc003csb.2
uc003csc.3
uc003csd.2
uc003cse.1
uc003csg.3
CTD 4134
GeneCards GC03M047892
HGNC HGNC:6862
HPA HPA038149
HPA038150
MIM 157132
neXtProt NX_P27816
PharmGKB PA30608
eggNOG NOG148882
GeneTree ENSGT00530000063491
HOGENOM HOG000139406
HOVERGEN HBG006323
InParanoid P27816
KO K10431
OrthoDB EOG7FFMR7
PhylomeDB P27816
TreeFam TF316358
ChiTaRS MAP4
GeneWiki MAP4
GenomeRNAi 4134
NextBio 16232
PMAP-CutDB P27816
PRO PR:P27816
Proteomes UP000005640
Bgee P27816
CleanEx HS_MAP4
ExpressionAtlas P27816
Genevestigator P27816
GO GO:0005737
GO:0070062
GO:0005874
GO:0005875
GO:0015630
GO:0072686
GO:0005886
GO:0044822
GO:0005198
GO:0051301
GO:0051294
GO:0051012
GO:0007052
InterPro IPR027324
IPR027323
IPR001084
PANTHER PTHR11501
PTHR11501:SF16
Pfam PF00418
PROSITE PS00229
PS51491

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032604

granulocyte macrophage colony-stimulating factor production

PMID:10336453[1]

ECO:0000314

P

Figure 4

complete
CACAO 6120

involved_in

GO:0000226

microtubule cytoskeleton organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P27546

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5M7W5

C

part_of:(CL:1001451)

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

PMID:23572511[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002586)

Seeded From UniProt

complete

involved_in

GO:1902856

negative regulation of non-motile cilium assembly

PMID:23572511[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002586)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97175
PANTHER:PTN000161190
RGD:3044
RGD:69329
WB:WBGene00004212

C

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000161190
UniProtKB:P11137

P

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266579
MGI:MGI:97175
MGI:MGI:97178
MGI:MGI:97180
PANTHER:PTN000161190
RGD:3044
RGD:69329
UniProtKB:P10636
WB:WBGene00004212

F

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0266579
MGI:MGI:97175
MGI:MGI:97178
MGI:MGI:97180
PANTHER:PTN000161190
UniProtKB:P10636

P

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

PMID:21822276[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

PMID:21822276[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051294

establishment of spindle orientation

PMID:21822276[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q7Z460

P

Seeded From UniProt

complete

involved_in

GO:0051294

establishment of spindle orientation

PMID:21822276[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051012

microtubule sliding

PMID:21822276[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

PMID:21822276[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051294

establishment of spindle orientation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27546
ensembl:ENSMUSP00000035055

P

Seeded From UniProt

complete

involved_in

GO:0051012

microtubule sliding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27546
ensembl:ENSMUSP00000035055

P

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27546
ensembl:ENSMUSP00000035055

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27546
ensembl:ENSMUSP00000035055

F

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27546
ensembl:ENSMUSP00000035055

P

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27546
ensembl:ENSMUSP00000035055

P

Seeded From UniProt

complete

enables

GO:0015631

tubulin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001084

F

Seeded From UniProt

complete

part_of

GO:0005875

microtubule associated complex

PMID:1905296[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:1905296[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yamaguchi, T et al. (1999) The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3. J. Biol. Chem. 274 15575-81 PubMed GONUTS page
  2. ↑ 2.0 2.1 Ghossoub, R et al. (2013) Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. J. Cell. Sci. 126 2583-94 PubMed GONUTS page
  3. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  4. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Samora, CP et al. (2011) MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Nat. Cell Biol. 13 1040-50 PubMed GONUTS page
  7. ↑ 7.0 7.1 Chapin, SJ & Bulinski, JC (1991) Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. J. Cell. Sci. 98 ( Pt 1) 27-36 PubMed GONUTS page
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