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HUMAN:MAP2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | METAP2 (ECO:0000255 with HAMAP-Rule:MF_03175) (synonyms: MNPEP, P67EIF2) | |
| Protein Name(s) | Methionine aminopeptidase 2 (ECO:0000255 with HAMAP-Rule:MF_03175)
MAP 2 (ECO:0000255 with HAMAP-Rule:MF_03175) MetAP 2 (ECO:0000255 with HAMAP-Rule:MF_03175) Initiation factor 2-associated 67 kDa glycoprotein (ECO:0000255 with HAMAP-Rule:MF_03175) p67 (ECO:0000255 with HAMAP-Rule:MF_03175) p67eIF2 (ECO:0000255 with HAMAP-Rule:MF_03175) Peptidase M (ECO:0000255 with HAMAP-Rule:MF_03175) | |
| External Links | ||
| UniProt | P50579 | |
| EMBL | U29607 U13261 AK091730 AK300836 AK315559 AC018475 CH471054 CH471054 BC013782 | |
| CCDS | CCDS9052.1 | |
| PIR | S52112 | |
| RefSeq | NP_006829.1 | |
| UniGene | Hs.444986 | |
| PDB | 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ | |
| PDBsum | 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ | |
| ProteinModelPortal | P50579 | |
| SMR | P50579 | |
| BioGrid | 116184 | |
| IntAct | P50579 | |
| MINT | MINT-2803706 | |
| STRING | 9606.ENSP00000325312 | |
| BindingDB | P50579 | |
| ChEMBL | CHEMBL3922 | |
| DrugBank | DB00134 DB01422 | |
| GuidetoPHARMACOLOGY | 1573 | |
| MEROPS | M24.002 | |
| PhosphoSite | P50579 | |
| DMDM | 1703273 | |
| REPRODUCTION-2DPAGE | IPI00033036 | |
| MaxQB | P50579 | |
| PaxDb | P50579 | |
| PeptideAtlas | P50579 | |
| PRIDE | P50579 | |
| DNASU | 10988 | |
| Ensembl | ENST00000261220 ENST00000323666 | |
| GeneID | 10988 | |
| KEGG | hsa:10988 | |
| UCSC | uc001tec.3 uc001tef.3 | |
| CTD | 10988 | |
| GeneCards | GC12P095800 | |
| HGNC | HGNC:16672 | |
| HPA | CAB013025 HPA019095 | |
| MIM | 601870 | |
| neXtProt | NX_P50579 | |
| PharmGKB | PA30765 | |
| eggNOG | COG0024 | |
| GeneTree | ENSGT00530000063220 | |
| HOGENOM | HOG000226278 | |
| HOVERGEN | HBG050495 | |
| InParanoid | P50579 | |
| KO | K01265 | |
| OMA | STRMEED | |
| PhylomeDB | P50579 | |
| TreeFam | TF300426 | |
| BRENDA | 3.4.11.18 | |
| Reactome | REACT_163919 | |
| ChiTaRS | METAP2 | |
| EvolutionaryTrace | P50579 | |
| GeneWiki | METAP2 | |
| GenomeRNAi | 10988 | |
| NextBio | 35517821 | |
| PRO | PR:P50579 | |
| Proteomes | UP000005640 | |
| Bgee | P50579 | |
| CleanEx | HS_METAP2 | |
| ExpressionAtlas | P50579 | |
| Genevestigator | P50579 | |
| GO | GO:0005737 GO:0005829 GO:0005886 GO:0004177 GO:0046872 GO:0070006 GO:0008235 GO:0044822 GO:0031365 GO:0018206 GO:0007603 GO:0070084 GO:0016485 GO:0022400 GO:0016056 | |
| Gene3D | 1.10.10.10 3.90.230.10 | |
| HAMAP | MF_03175 | |
| InterPro | IPR001714 IPR000994 IPR002468 IPR018349 IPR011991 | |
| Pfam | PF00557 | |
| PRINTS | PR00599 | |
| SUPFAM | SSF55920 | |
| TIGRFAMs | TIGR00501 | |
| PROSITE | PS01202 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0031365 |
N-terminal protein amino acid modification |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018206 |
peptidyl-methionine modification |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016485 |
protein processing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008235 |
metalloexopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004177 |
aminopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004177 |
aminopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008235 |
metalloexopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000111476 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070006 |
metalloaminopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000111476 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070084 |
protein initiator methionine removal |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000111476 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022400 |
regulation of rhodopsin mediated signaling pathway |
Reactome:R-HSA-2514859 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-2534096 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004177 |
aminopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Li, X & Chang, YH (1996) Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. Biochem. Biophys. Res. Commun. 227 152-9 PubMed GONUTS page
- ↑ Selvakumar, P et al. (2004) High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas. Clin. Cancer Res. 10 2771-5 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
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