HUMAN:MAP1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAP1A (synonyms: MAP1L)
Protein Name(s)	Microtubule-associated protein 1A MAP-1A Proliferation-related protein p80 MAP1A heavy chain MAP1 light chain LC2
External Links
UniProt	P78559
EMBL	U38291 U38292 AC019011 AF200415 U80458 Z47038 U14577
CCDS	CCDS42031.1
PIR	I38857
RefSeq	NP_002364.5
UniGene	Hs.194301 Hs.619338
ProteinModelPortal	P78559
BioGrid	110303
IntAct	P78559
MINT	MINT-1203375
STRING	9606.ENSP00000300231
DrugBank	DB01196
PhosphoSite	P78559
DMDM	313104325
MaxQB	P78559
PaxDb	P78559
PRIDE	P78559
Ensembl	ENST00000300231
GeneID	4130
KEGG	hsa:4130
UCSC	uc001zrt.3
CTD	4130
GeneCards	GC15P043803
HGNC	HGNC:6835
HPA	HPA039063 HPA039064
MIM	600178
neXtProt	NX_P78559
eggNOG	NOG12793
GeneTree	ENSGT00550000074593
HOGENOM	HOG000231839
HOVERGEN	HBG052408
InParanoid	P78559
KO	K10429
PhylomeDB	P78559
TreeFam	TF350229
ChiTaRS	MAP1A
GeneWiki	MAP1A
GenomeRNAi	4130
NextBio	16214
PRO	PR:P78559
Proteomes	UP000005640
Bgee	P78559
CleanEx	HS_MAP1A
ExpressionAtlas	P78559
Genevestigator	P78559
GO	GO:0005829 GO:0005874 GO:0005875 GO:0005198 GO:0000226 GO:0007605
Gene3D	3.60.15.10
InterPro	IPR001279 IPR026074 IPR015656
PANTHER	PTHR13843 PTHR13843:SF6
SUPFAM	SSF56281

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:1901588	dendritic microtubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	C	part_of:(CL:0000121) part_of:(UBERON:0002979)	Seeded From UniProt	complete
part_of	GO:0043194	axon initial segment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	C	part_of:(CL:0000121) part_of:(UBERON:0002979)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	C	part_of:(CL:0000121) part_of:(UBERON:0002979)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	C	part_of:(CL:0000121) part_of:(UBERON:0002979)	Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0000121) occurs_in:(UBERON:0002979) occurs_at:(GO:0043194)	Seeded From UniProt	complete
part_of	GO:0150001	primary dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(CL:1001611) exists_during:(GO:0048666)	Seeded From UniProt	complete
part_of	GO:0044307	dendritic branch	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(CL:1001611) exists_during:(GO:0048666)	Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(CL:1001611) part_of:(GO:0044307) exists_during:(GO:0048666)\|part_of(CL:1001611) part_of:(GO:0150001) exists_during:(GO:0048666)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(CL:1001611) exists_during:(GO:0048666)	Seeded From UniProt	complete
involved_in	GO:1902817	negative regulation of protein localization to microtubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0000121) occurs_in:(UBERON:0002979) regulates_o_occurs_in:(GO:1901588) occurs_in:(GO:0036477) regulates_o_occurs_in:(GO:0036477) has_regulation_target:(UniProtKB:Q15700)	Seeded From UniProt	complete
involved_in	GO:0070050	neuron cellular homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0000121) occurs_in:(UBERON:0002979)	Seeded From UniProt	complete
involved_in	GO:0050882	voluntary musculoskeletal movement	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0000121) occurs_in:(UBERON:0002979) occurs_at:(GO:1901588)\|occurs_in(CL:0000121) occurs_in:(UBERON:0002979) occurs_at:(GO:0043194)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(CL:1001451)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(UBERON:0009583) exists_during:(GO:0021510)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(UBERON:0000044) exists_during:(GO:0021510)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(UBERON:0009583) exists_during:(GO:0021510)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	C	part_of:(UBERON:0009583) exists_during:(GO:0021510)	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34926	F	occurs_in:(UBERON:0002240) occurs_in:(UBERON:0019248)\|occurs_in:(UBERON:0002240) happens_during:(UBERON:0035946)\|occurs_in(UBERON:0002240) occurs_in:(UBERON:0007023)	Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	F	occurs_in:(UBERON:0001890)	Seeded From UniProt	complete
enables	GO:0008093	cytoskeletal adaptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	F	occurs_at:(GO:0005874) occurs_in:(UBERON:0000955) has_input:(UniProtKB:Q91XM9)\|occurs_at(GO:0005874) occurs_in:(UBERON:0000955) has_input:(UniProtKB:Q62108)	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	F	occurs_in:(UBERON:0001890)	Seeded From UniProt	complete
involved_in	GO:2000010	positive regulation of protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	has_regulation_target:(UniProtKB:P35436) occurs_in:(CL:0000540) regulates_o_occurs_in:(CL:0000540) has_target_end_location:(GO:0097060)\|has_regulation_target(UniProtKB:Q01097) occurs_in:(CL:0000540) regulates_o_occurs_in:(CL:0000540) has_target_end_location:(GO:0097060)	Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	has_regulation_target:(UniProtKB:Q91XM9) occurs_in:(CL:0000540) regulates_o_occurs_in:(CL:0000540) has_target_end_location:(GO:0014069)	Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P		Seeded From UniProt	complete
involved_in	GO:0099641	anterograde axonal protein transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0002608) has_input:(UniProtKB:P35436)\|occurs_in(CL:0002608) has_input:(UniProtKB:Q01097)	Seeded From UniProt	complete
involved_in	GO:0099642	retrograde axonal protein transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0002608) has_input:(UniProtKB:P35436)\|occurs_in(CL:0002608) has_input:(UniProtKB:Q01097)	Seeded From UniProt	complete
involved_in	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P	occurs_in:(CL:0000540) has_regulation_target:(UniProtKB:Q91XM9) part_of:(GO:0035865)	Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYR6	P		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:8812494^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000353807 UniProtKB:Q66K74	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259108 MGI:MGI:2443304 PANTHER:PTN000353807 RGD:3043	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000353807 UniProtKB:Q66K74	C		Seeded From UniProt	complete
involved_in	GO:0031114	regulation of microtubule depolymerization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000353807 UniProtKB:B2ZZ14	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259108 MGI:MGI:2443304 PANTHER:PTN000353807 RGD:3042 RGD:3043	C		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1306778 PANTHER:PTN000353807	P		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1306776 MGI:MGI:2443304 PANTHER:PTN000353807 UniProtKB:Q66K74	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259108 MGI:MGI:1306776 MGI:MGI:2443304 PANTHER:PTN000353807 RGD:3043 UniProtKB:Q66K74	F		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259108 MGI:MGI:1306778 PANTHER:PTN000353807	P		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259108 PANTHER:PTN000353807 RGD:3042 RGD:3043	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000353807 RGD:3043 UniProtKB:Q66K74	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1306776 MGI:MGI:1306778 PANTHER:PTN000353807 UniProtKB:P46821 UniProtKB:Q66K74	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1306776 PANTHER:PTN000353807 RGD:3042 RGD:3043	F		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259108 MGI:MGI:1306776 MGI:MGI:2443304 PANTHER:PTN000353807	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099642	C		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015656 InterPro:IPR026074	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015656 InterPro:IPR026074	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015656 InterPro:IPR026074	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:26609151^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:8812494^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^2.0 ^2.1 Fink, JK et al. (1996) Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. Genomics 35 577-85 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Takei, Y et al. (2015) Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J. Neurosci. 35 15539-54 PubMed GONUTS page

[PMID:28386764-1] Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:8812494-2] 2.0 ^2.1 Fink, JK et al. (1996) Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. Genomics 35 577-85 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26609151-4] Takei, Y et al. (2015) Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J. Neurosci. 35 15539-54 PubMed GONUTS page

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HUMAN:MAP1A

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