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HUMAN:MA2B1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MAN2B1 (synonyms: LAMAN, MANB) | |
| Protein Name(s) | Lysosomal alpha-mannosidase
Laman Lysosomal acid alpha-mannosidase Mannosidase alpha class 2B member 1 Mannosidase alpha-B Lysosomal alpha-mannosidase A peptide Lysosomal alpha-mannosidase B peptide Lysosomal alpha-mannosidase C peptide Lysosomal alpha-mannosidase D peptide Lysosomal alpha-mannosidase E peptide | |
| External Links | ||
| UniProt | O00754 | |
| EMBL | U05572 U60266 U60899 U60885 U60886 U60887 U60888 U60889 U60890 U60891 U60892 U60893 U60894 U60895 U60896 U60897 U60898 AC010422 CH471106 BC000736 U68567 | |
| CCDS | CCDS32919.1 CCDS54224.1 | |
| RefSeq | NP_000519.2 NP_001166969.1 | |
| UniGene | Hs.356769 Hs.657204 | |
| ProteinModelPortal | O00754 | |
| SMR | O00754 | |
| BioGrid | 110298 | |
| IntAct | O00754 | |
| MINT | MINT-253662 | |
| STRING | 9606.ENSP00000395473 | |
| BindingDB | O00754 | |
| ChEMBL | CHEMBL4059 | |
| CAZy | GH38 | |
| PhosphoSite | O00754 | |
| MaxQB | O00754 | |
| PaxDb | O00754 | |
| PRIDE | O00754 | |
| DNASU | 4125 | |
| Ensembl | ENST00000221363 ENST00000456935 | |
| GeneID | 4125 | |
| KEGG | hsa:4125 | |
| UCSC | uc002mub.2 uc010dyv.1 | |
| CTD | 4125 | |
| GeneCards | GC19M012757 | |
| GeneReviews | MAN2B1 | |
| HGNC | HGNC:6826 | |
| HPA | HPA041530 | |
| MIM | 248500 609458 | |
| neXtProt | NX_O00754 | |
| Orphanet | 309288 309282 | |
| PharmGKB | PA30575 | |
| eggNOG | NOG306356 | |
| GeneTree | ENSGT00510000046304 | |
| HOGENOM | HOG000007676 | |
| HOVERGEN | HBG052391 | |
| InParanoid | O00754 | |
| KO | K12311 | |
| OMA | NMQLTVL | |
| OrthoDB | EOG786H2P | |
| PhylomeDB | O00754 | |
| TreeFam | TF313840 | |
| BRENDA | 3.2.1.24 | |
| ChiTaRS | MAN2B1 | |
| GenomeRNAi | 4125 | |
| NextBio | 16196 | |
| PRO | PR:O00754 | |
| Proteomes | UP000005640 | |
| Bgee | O00754 | |
| CleanEx | HS_MAN2B1 | |
| ExpressionAtlas | O00754 | |
| Genevestigator | O00754 | |
| GO | GO:0070062 GO:0005764 GO:0004559 GO:0030246 GO:0008270 GO:0006464 GO:0006013 GO:0006517 | |
| Gene3D | 1.20.1270.50 2.60.40.1180 3.20.110.10 | |
| InterPro | IPR011013 IPR011330 IPR013780 IPR027291 IPR011682 IPR015341 IPR000602 IPR028995 | |
| Pfam | PF09261 PF01074 PF07748 | |
| SMART | SM00872 | |
| SUPFAM | SSF74650 SSF88688 SSF88713 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007311) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006464 |
cellular protein modification process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006517 |
protein deglycosylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0011740 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006013 |
mannose metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107286 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005774 |
vacuolar membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000176485 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004559 |
alpha-mannosidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0027611 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004559 |
alpha-mannosidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000602 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006013 |
mannose metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000602 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004559 |
alpha-mannosidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006517 |
protein deglycosylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004559 |
alpha-mannosidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043202 |
lysosomal lumen |
Reactome:R-HSA-8853686 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035578 |
azurophil granule lumen |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009313 |
oligosaccharide catabolic process |
Reactome:R-HSA-8853383 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Liao, YF et al. (1996) Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase. J. Biol. Chem. 271 28348-58 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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