HUMAN:MA1B1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAN1B1
Protein Name(s)	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase ER alpha-1,2-mannosidase ER mannosidase 1 ERMan1 Man9GlcNAc2-specific-processing alpha-mannosidase Mannosidase alpha class 1B member 1
External Links
UniProt	Q9UKM7
EMBL	AF148509 AF145732 AY358465 AL929554 AL807752 AL807752 AL929554 BC002953 BC006079
CCDS	CCDS7029.1
RefSeq	NP_057303.2
UniGene	Hs.279881
PDB	1FMI 1FO2 1FO3 1X9D
PDBsum	1FMI 1FO2 1FO3 1X9D
ProteinModelPortal	Q9UKM7
SMR	Q9UKM7
BioGrid	116414
IntAct	Q9UKM7
MINT	MINT-6610355
STRING	9606.ENSP00000360645
BindingDB	Q9UKM7
ChEMBL	CHEMBL2308
CAZy	GH47
PhosphoSite	Q9UKM7
DMDM	93195043
MaxQB	Q9UKM7
PaxDb	Q9UKM7
PRIDE	Q9UKM7
DNASU	11253
Ensembl	ENST00000371589
GeneID	11253
KEGG	hsa:11253
UCSC	uc004cld.3
CTD	11253
GeneCards	GC09P139981
H-InvDB	HIX0035043
HGNC	HGNC:6823
HPA	HPA051516
MIM	604346 614202
neXtProt	NX_Q9UKM7
Orphanet	88616 397941
PharmGKB	PA30572
eggNOG	NOG300315
GeneTree	ENSGT00390000016529
HOGENOM	HOG000181987
HOVERGEN	HBG052389
InParanoid	Q9UKM7
KO	K01230
OMA	KEFAWGH
OrthoDB	EOG7ZGX2S
PhylomeDB	Q9UKM7
TreeFam	TF354274
BRENDA	3.2.1.113
Reactome	REACT_25091
UniPathway	UPA00378
ChiTaRS	MAN1B1
EvolutionaryTrace	Q9UKM7
GeneWiki	MAN1B1
GenomeRNAi	11253
NextBio	42822
PRO	PR:Q9UKM7
Proteomes	UP000005640
Bgee	Q9UKM7
CleanEx	HS_MAN1B1
ExpressionAtlas	Q9UKM7
Genevestigator	Q9UKM7
GO	GO:0005783 GO:0005789 GO:0044322 GO:0016021 GO:0016020 GO:0031982 GO:0005509 GO:0004571 GO:0044267 GO:0030433 GO:0009311 GO:0043687 GO:0006457 GO:0006487 GO:0018279
Gene3D	1.50.10.50
InterPro	IPR001382
PANTHER	PTHR11742
Pfam	PF01532
PRINTS	PR00747
SUPFAM	SSF48225

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0036509	trimming of terminal mannose on B branch	PMID:10521544^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	PMID:21062743^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0005783)	Seeded From UniProt	complete
involved_in	GO:0036509	trimming of terminal mannose on B branch	PMID:18003979^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904380	endoplasmic reticulum mannose trimming	PMID:18003979^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	PMID:18003979^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0044322)	Seeded From UniProt	complete
part_of	GO:0044322	endoplasmic reticulum quality control compartment	PMID:18003979^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	PMID:18003979^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	part_of:(GO:0097466)	Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	PMID:22160784^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0036508	protein alpha-1,2-demannosylation	PMID:22160784^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:24769233^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036508	protein alpha-1,2-demannosylation	PMID:10521544^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	PMID:10521544^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	PMID:18003979^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18003979^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036508	protein alpha-1,2-demannosylation	PMID:10521544^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:18003979^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	PMID:12090241^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2684954 PANTHER:PTN002482736 PomBase:SPAC2E1P5.01c SGD:S000003892 UniProtKB:Q9UKM7	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002482736 UniProtKB:A0A1D8PD38 UniProtKB:Q9UKM7	C		Seeded From UniProt	complete
involved_in	GO:0006491	N-glycan processing	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000201533 TAIR:locus:2017597 TAIR:locus:2092965 TAIR:locus:2198299 UniProtKB:A0A1D8PD38	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000201533 SGD:S000003892 SGD:S000004047 UniProtKB:A0A1D8PD38 UniProtKB:Q9UKM7	C		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259170 MGI:MGI:2684954 PANTHER:PTN000201533 PomBase:SPAC2E1P5.01c SGD:S000003892 UniProtKB:A0A1D5PBZ7 UniProtKB:A0A1D8PD38 UniProtKB:Q9UKM7	F		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2AJ15 ensembl:ENSMUSP00000036996	P		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A2AJ15 ensembl:ENSMUSP00000036996	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012341	F		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001382 InterPro:IPR036026	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001382 InterPro:IPR036026	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001382 InterPro:IPR036026	C		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.1.113	F		Seeded From UniProt	complete
part_of	GO:0044322	endoplasmic reticulum quality control compartment	PMID:21062743^[2] Reactome:R-HSA-901074 Reactome:R-HSA-901039 Reactome:R-HSA-901036 Reactome:R-HSA-901024	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:22160784^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:22160784^[4] PMID:10409699^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	PMID:22160784^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009311	oligosaccharide metabolic process	PMID:10409699^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	PMID:10409699^[9] PMID:10521544^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10521544^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:10521544^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0036512	trimming of second mannose on A branch	Reactome:R-HSA-901036	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036511	trimming of first mannose on A branch	Reactome:R-HSA-901024	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036510	trimming of terminal mannose on C branch	Reactome:R-HSA-901039	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036509	trimming of terminal mannose on B branch	Reactome:R-HSA-901074	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
involved_in	GO:0006486	protein glycosylation	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00378	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Tremblay, LO & Herscovics, A (1999) Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis. Glycobiology 9 1073-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Groisman, B et al. (2011) Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J. Biol. Chem. 286 1292-300 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Avezov, E et al. (2008) Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Mol. Biol. Cell 19 216-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Aikawa, J et al. (2012) In vitro mannose trimming property of human ER α-1,2 mannosidase I. Glycoconj. J. 29 35-45 PubMed GONUTS page
↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Herscovics, A et al. (2002) The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported. Glycobiology 12 14G-15G PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Gonzalez, DS et al. (1999) Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J. Biol. Chem. 274 21375-86 PubMed GONUTS page

[PMID:10521544-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Tremblay, LO & Herscovics, A (1999) Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis. Glycobiology 9 1073-8 PubMed GONUTS page

[PMID:21062743-2] 2.0 ^2.1 Groisman, B et al. (2011) Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J. Biol. Chem. 286 1292-300 PubMed GONUTS page

[PMID:18003979-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Avezov, E et al. (2008) Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Mol. Biol. Cell 19 216-25 PubMed GONUTS page

[PMID:22160784-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Aikawa, J et al. (2012) In vitro mannose trimming property of human ER α-1,2 mannosidase I. Glycoconj. J. 29 35-45 PubMed GONUTS page

[PMID:24769233-5] Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page

[PMID:19946888-6] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:12090241-7] Herscovics, A et al. (2002) The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported. Glycobiology 12 14G-15G PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10409699-9] 9.0 ^9.1 ^9.2 Gonzalez, DS et al. (1999) Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J. Biol. Chem. 274 21375-86 PubMed GONUTS page

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HUMAN:MA1B1

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References

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