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HUMAN:MA1A1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MAN1A1
Protein Name(s) Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

Man(9)-alpha-mannosidase Man9-mannosidase Mannosidase alpha class 1A member 1 Processing alpha-1,2-mannosidase IA Alpha-1,2-mannosidase IA

External Links
UniProt P33908
EMBL AL022722
AL078600
AL078600
AL138886
CH471051
BC065827
X74837
CCDS CCDS5122.1
PIR S38965
RefSeq NP_005898.2
UniGene Hs.102788
Hs.742378
ProteinModelPortal P33908
SMR P33908
BioGrid 110294
STRING 9606.ENSP00000357453
ChEMBL CHEMBL5915
CAZy GH47
PhosphoSite P33908
DMDM 62906886
MaxQB P33908
PaxDb P33908
PRIDE P33908
Ensembl ENST00000368468
GeneID 4121
KEGG hsa:4121
UCSC uc003pym.2
uc010kei.3
CTD 4121
GeneCards GC06M119540
HGNC HGNC:6821
HPA CAB037058
MIM 604344
neXtProt NX_P33908
PharmGKB PA30570
eggNOG NOG300315
GeneTree ENSGT00390000016529
HOGENOM HOG000181988
HOVERGEN HBG052389
InParanoid P33908
KO K01230
OMA YARTTLK
OrthoDB EOG7X0VH1
PhylomeDB P33908
TreeFam TF313420
Reactome REACT_25396
UniPathway UPA00378
ChiTaRS MAN1A1
GeneWiki MAN1A1
GenomeRNAi 4121
NextBio 16180
PRO PR:P33908
Proteomes UP000005640
Bgee P33908
CleanEx HS_MAN1A1
Genevestigator P33908
GO GO:0005783
GO:0005793
GO:0070062
GO:0000139
GO:0016021
GO:0016020
GO:0005509
GO:0015923
GO:0004571
GO:0044267
GO:0043687
GO:0018279
Gene3D 1.50.10.50
InterPro IPR001382
PANTHER PTHR11742
Pfam PF01532
PRINTS PR00747
SUPFAM SSF48225

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

PMID:15308636[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006491

N-glycan processing

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201533
TAIR:locus:2017597
TAIR:locus:2092965
TAIR:locus:2198299
UniProtKB:A0A1D8PD38

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201533
SGD:S000003892
SGD:S000004047
UniProtKB:A0A1D8PD38
UniProtKB:Q9UKM7

C

Seeded From UniProt

complete

enables

GO:0004571

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259170
MGI:MGI:2684954
PANTHER:PTN000201533
PomBase:SPAC2E1P5.01c
SGD:S000003892
UniProtKB:A0A1D5PBZ7
UniProtKB:A0A1D8PD38
UniProtKB:Q9UKM7

F

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104676
MGI:MGI:104677
PANTHER:PTN000201534

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P45700
ensembl:ENSMUSP00000003843

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012341

F

Seeded From UniProt

complete

enables

GO:0004571

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001382
InterPro:IPR036026

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001382
InterPro:IPR036026

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001382
InterPro:IPR036026

C

Seeded From UniProt

complete

enables

GO:0004571

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.113

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:8223597[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0015923

mannosidase activity

PMID:8223597[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:8223597[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:8223597[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004571

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

PMID:8223597[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1904381

Golgi apparatus mannose trimming

Reactome:R-HSA-964827

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

Reactome:R-HSA-964830
Reactome:R-HSA-964825
Reactome:R-HSA-964737

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

involved_in

GO:0006486

protein glycosylation

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00378

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ Breuza, L et al. (2004) Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. J. Biol. Chem. 279 47242-53 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Bause, E et al. (1993) Molecular cloning and primary structure of Man9-mannosidase from human kidney. Eur. J. Biochem. 217 535-40 PubMed GONUTS page
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