GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:LPH
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LCT (synonyms: LPH) | |
| Protein Name(s) | Lactase-phlorizin hydrolase
Lactase-glycosylceramidase Lactase Phlorizin hydrolase | |
| External Links | ||
| UniProt | P09848 | |
| EMBL | X07994 M61850 M61834 M61835 M61836 M61837 M61838 M61839 M61840 M61841 M61842 M61843 M61844 M61845 M61846 M61847 M61848 M61849 AC011893 | |
| CCDS | CCDS2178.1 | |
| PIR | S01168 | |
| RefSeq | NP_002290.2 | |
| UniGene | Hs.551506 | |
| ProteinModelPortal | P09848 | |
| BioGrid | 110130 | |
| IntAct | P09848 | |
| MINT | MINT-3380713 | |
| STRING | 9606.ENSP00000264162 | |
| ChEMBL | CHEMBL1075131 | |
| DrugBank | DB00126 | |
| CAZy | GH1 | |
| PhosphoSite | P09848 | |
| DMDM | 311033425 | |
| MaxQB | P09848 | |
| PaxDb | P09848 | |
| PRIDE | P09848 | |
| Ensembl | ENST00000264162 | |
| GeneID | 3938 | |
| KEGG | hsa:3938 | |
| UCSC | uc002tuu.1 | |
| CTD | 3938 | |
| GeneCards | GC02M136567 | |
| H-InvDB | HIX0030024 HIX0117702 | |
| HGNC | HGNC:6530 | |
| HPA | HPA007408 | |
| MIM | 223000 603202 | |
| neXtProt | NX_P09848 | |
| Orphanet | 53690 319681 | |
| PharmGKB | PA30315 | |
| eggNOG | COG2723 | |
| GeneTree | ENSGT00550000074452 | |
| HOGENOM | HOG000024957 | |
| HOVERGEN | HBG006290 | |
| InParanoid | P09848 | |
| KO | K01229 | |
| OMA | FADYATF | |
| PhylomeDB | P09848 | |
| TreeFam | TF314803 | |
| BioCyc | MetaCyc:HS03945-MONOMER | |
| Reactome | REACT_9472 | |
| ChiTaRS | LCT | |
| GenomeRNAi | 3938 | |
| NextBio | 15465 | |
| PRO | PR:P09848 | |
| Proteomes | UP000005640 | |
| Bgee | P09848 | |
| CleanEx | HS_LCT | |
| ExpressionAtlas | P09848 | |
| Genevestigator | P09848 | |
| GO | GO:0016324 GO:0005887 GO:0016020 GO:0005886 GO:0017042 GO:0000016 GO:0005975 GO:0044245 GO:0044281 | |
| Gene3D | 3.20.20.80 | |
| InterPro | IPR001360 IPR018120 IPR013781 IPR017853 | |
| PANTHER | PTHR10353 | |
| Pfam | PF00232 | |
| PRINTS | PR00131 | |
| SUPFAM | SSF51445 | |
| PROSITE | PS00572 PS00653 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008422 |
beta-glucosidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000039458 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000016 |
lactase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000039544 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004553 |
hydrolase activity, hydrolyzing O-glycosyl compounds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000016 |
lactase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017042 |
glycosylceramidase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000016 |
lactase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044245 |
polysaccharide digestion |
Reactome:R-HSA-189085 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-189062 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Mantei, N et al. (1988) Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme. EMBO J. 7 2705-13 PubMed GONUTS page
c
h
