HUMAN:LIPL

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LPL (synonyms: LIPD)
Protein Name(s)	Lipoprotein lipase LPL
External Links
UniProt	P06858
EMBL	M15856 X14390 X54516 M76722 S76076 S76077 BT006726 AK312311 CH471080 BC011353 X68111
CCDS	CCDS6012.1
PIR	A26082
RefSeq	NP_000228.1
UniGene	Hs.180878
ProteinModelPortal	P06858
SMR	P06858
BioGrid	110205
IntAct	P06858
MINT	MINT-1369348
STRING	9606.ENSP00000309757
BindingDB	P06858
ChEMBL	CHEMBL2060
DrugBank	DB05269 DB06439
PhosphoSite	P06858
DMDM	126314
MaxQB	P06858
PaxDb	P06858
PRIDE	P06858
DNASU	4023
Ensembl	ENST00000311322
GeneID	4023
KEGG	hsa:4023
UCSC	uc003wzk.4
CTD	4023
GeneCards	GC08P019759
GeneReviews	LPL
HGNC	HGNC:6677
HPA	HPA048749
MIM	238600 609708
neXtProt	NX_P06858
Orphanet	309015 70470
PharmGKB	PA232
eggNOG	NOG40923
GeneTree	ENSGT00760000119069
HOGENOM	HOG000038553
HOVERGEN	HBG002259
InParanoid	P06858
KO	K01059
OMA	ESVANCH
PhylomeDB	P06858
TreeFam	TF324997
BRENDA	3.1.1.34
Reactome	REACT_24968 REACT_27161 REACT_6841
GeneWiki	Lipoprotein_lipase
GenomeRNAi	4023
NextBio	15776
PRO	PR:P06858
Proteomes	UP000005640
Bgee	P06858
CleanEx	HS_LPL
ExpressionAtlas	P06858
Genevestigator	P06858
GO	GO:0031225 GO:0009986 GO:0042627 GO:0031012 GO:0005576 GO:0005615 GO:0070062 GO:0005886 GO:0034361 GO:0034185 GO:0008201 GO:0004465 GO:0004620 GO:0005102 GO:0017129 GO:0004806 GO:0034371 GO:0006633 GO:0042157 GO:0006644 GO:0007603 GO:0010886 GO:0010744 GO:0010890 GO:0009409 GO:0042493 GO:0001523 GO:0044281 GO:0019432 GO:0019433 GO:0070328 GO:0006641 GO:0034372
Gene3D	2.60.60.20 3.40.50.1820
InterPro	IPR029058 IPR016272 IPR008976 IPR013818 IPR002330 IPR001024 IPR000734
PANTHER	PTHR11610 PTHR11610:SF3
Pfam	PF00151 PF01477
PIRSF	PIRSF000865
PRINTS	PR00822 PR00821
SMART	SM00308
SUPFAM	SSF49723 SSF53474
TIGRFAMs	TIGR03230
PROSITE	PS00120 PS50095

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034371	chylomicron remodeling	PMID:11342582^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	PMID:11342582^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:11342582^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:11342582^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11342582^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:11342582^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:11342582^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:11342582^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	PMID:29794473^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	part_of:(GO:0031670) occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0031670	cellular response to nutrient	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11152	P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:30559189^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:30559189^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:30559189^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:30559189^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16179346^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:16179346^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:27578112^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:27578112^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:27578112^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:27578112^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:2110364^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:2110364^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:2110364^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:2340307^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2340307^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:2340307^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055096	low-density lipoprotein particle mediated signaling	PMID:25149060^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:25149060^[8]	ECO:0000305	curator inference used in manual assertion	GO:0090197	P	occurs_in:(CL:0000235) part_of:(GO:0055096)	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:25149060^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235) part_of:(GO:0055096)	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:25149060^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	PMID:25149060^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235) part_of:(GO:0055096)	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:17018885^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P02655	P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:3973011^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	P		Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	PMID:3973011^[11]	ECO:0000305	curator inference used in manual assertion	GO:0004465	P		Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	PMID:15178420^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6Q788	F		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:182536^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:3973011^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	P		Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	PMID:12573449^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010886	positive regulation of cholesterol storage	PMID:12573449^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PMID:12573449^[14]	ECO:0000305	curator inference used in manual assertion	GO:0010890	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:12573449^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	PMID:10727238^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	P		Seeded From UniProt	complete
involved_in	GO:0006641	triglyceride metabolic process	PMID:10727238^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:182536^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:3973011^[11]	ECO:0000305	curator inference used in manual assertion	GO:0004465	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12573449^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:10085125^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99523	F		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	PMID:182536^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	PMID:12573449^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	PMID:10727238^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	F		Seeded From UniProt	complete
enables	GO:0004620	phospholipase activity	PMID:10727238^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	F		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:3973011^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:10727238^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11151	F		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:0031670	cellular response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	C		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	C		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	F		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	F		Seeded From UniProt	complete
involved_in	GO:1900077	negative regulation of cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	P		Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	P		Seeded From UniProt	complete
enables	GO:0017129	triglyceride binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	F		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	P		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	C		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06000 ensembl:ENSRNOP00000016543	F		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002330	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002330 InterPro:IPR016272 InterPro:IPR033906	P		Seeded From UniProt	complete
enables	GO:0052689	carboxylic ester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000734 InterPro:IPR016272	F		Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.1.34	F		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:24608080^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000235) has_agent:(GO:1990777) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0043495	protein membrane anchor	PMID:24608080^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	occurs_in:(CL:0000235) has_input:(GO:1990777) part_of:(GO:0010884)	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:1969408^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051004	regulation of lipoprotein lipase activity	Reactome:R-HSA-8963889	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	Reactome:R-HSA-8963901	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8857928 Reactome:R-HSA-6784861 Reactome:R-HSA-6784676 Reactome:R-HSA-6784628 Reactome:R-HSA-560498 Reactome:R-HSA-2395768 Reactome:R-HSA-174757	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0850	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0162	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Lutz, EP et al. (2001) Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues. J. Clin. Invest. 107 1183-92 PubMed GONUTS page
↑ Hu, X et al. (2018) MiR-27b Impairs Adipocyte Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting LPL. Cell. Physiol. Biochem. 47 545-555 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Birrane, G et al. (2018) Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc. Natl. Acad. Sci. U.S.A. PubMed GONUTS page
↑ ^4.0 ^4.1 Zhang, L et al. (2005) Calcium triggers folding of lipoprotein lipase into active dimers. J. Biol. Chem. 280 42580-91 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Pingitore, P et al. () Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia. J Clin Lipidol 10 816-823 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Beg, OU et al. (1990) Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity. Proc. Natl. Acad. Sci. U.S.A. 87 3474-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Zechner, R (1990) Rapid and simple isolation procedure for lipoprotein lipase from human milk. Biochim. Biophys. Acta 1044 20-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 He, PP et al. (2014) MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages. Biochimie 106 81-90 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Pulawa, LK et al. (2007) Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J. Lipid Res. 48 145-51 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Wang, CS et al. (1985) Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J. Clin. Invest. 75 384-90 PubMed GONUTS page
↑ Fruchart-Najib, J et al. (2004) Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem. Biophys. Res. Commun. 319 397-404 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kinnunen, PK & Ehnolm, C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett. 65 354-7 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Milosavljevic, D et al. (2003) VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass. Biochim. Biophys. Acta 1631 51-60 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 MacPhee, CE et al. (2000) Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Biochemistry 39 3433-40 PubMed GONUTS page
↑ Nielsen, MS et al. (1999) Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem. 274 8832-6 PubMed GONUTS page
↑ ^17.0 ^17.1 Zhang, M et al. (2014) MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Atherosclerosis 234 54-64 PubMed GONUTS page
↑ Emi, M et al. (1990) Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency. J. Biol. Chem. 265 5910-6 PubMed GONUTS page

[PMID:11342582-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Lutz, EP et al. (2001) Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues. J. Clin. Invest. 107 1183-92 PubMed GONUTS page

[PMID:29794473-2] Hu, X et al. (2018) MiR-27b Impairs Adipocyte Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting LPL. Cell. Physiol. Biochem. 47 545-555 PubMed GONUTS page

[PMID:30559189-3] 3.0 ^3.1 ^3.2 ^3.3 Birrane, G et al. (2018) Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc. Natl. Acad. Sci. U.S.A. PubMed GONUTS page

[PMID:16179346-4] 4.0 ^4.1 Zhang, L et al. (2005) Calcium triggers folding of lipoprotein lipase into active dimers. J. Biol. Chem. 280 42580-91 PubMed GONUTS page

[PMID:27578112-5] 5.0 ^5.1 ^5.2 ^5.3 Pingitore, P et al. () Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia. J Clin Lipidol 10 816-823 PubMed GONUTS page

[PMID:2110364-6] 6.0 ^6.1 ^6.2 Beg, OU et al. (1990) Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity. Proc. Natl. Acad. Sci. U.S.A. 87 3474-8 PubMed GONUTS page

[PMID:2340307-7] 7.0 ^7.1 ^7.2 Zechner, R (1990) Rapid and simple isolation procedure for lipoprotein lipase from human milk. Biochim. Biophys. Acta 1044 20-5 PubMed GONUTS page

[PMID:25149060-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 He, PP et al. (2014) MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages. Biochimie 106 81-90 PubMed GONUTS page

[PMID:16502470-9] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:17018885-10] Pulawa, LK et al. (2007) Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J. Lipid Res. 48 145-51 PubMed GONUTS page

[PMID:3973011-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Wang, CS et al. (1985) Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J. Clin. Invest. 75 384-90 PubMed GONUTS page

[PMID:15178420-12] Fruchart-Najib, J et al. (2004) Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem. Biophys. Res. Commun. 319 397-404 PubMed GONUTS page

[PMID:182536-13] 13.0 ^13.1 ^13.2 Kinnunen, PK & Ehnolm, C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett. 65 354-7 PubMed GONUTS page

[PMID:12573449-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Milosavljevic, D et al. (2003) VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass. Biochim. Biophys. Acta 1631 51-60 PubMed GONUTS page

[PMID:10727238-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 MacPhee, CE et al. (2000) Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Biochemistry 39 3433-40 PubMed GONUTS page

[PMID:10085125-16] Nielsen, MS et al. (1999) Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem. 274 8832-6 PubMed GONUTS page

[PMID:24608080-17] 17.0 ^17.1 Zhang, M et al. (2014) MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages. Atherosclerosis 234 54-64 PubMed GONUTS page

[PMID:1969408-18] Emi, M et al. (1990) Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency. J. Biol. Chem. 265 5910-6 PubMed GONUTS page

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