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HUMAN:LIPC

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LIPC (synonyms: HTGL)
Protein Name(s) Hepatic triacylglycerol lipase

HL Hepatic lipase Lipase member C

External Links
UniProt P11150
EMBL D83548
X07228
J03540
J03895
M29194
M29186
M29187
M29188
M29189
M29190
M29191
M29192
M29193
D83062
M35433
M35425
M35426
M35427
M35429
M35430
M35431
M35432
AK292631
AK315306
AC018904
AC084781
BC132825
BC136495
AF037404
CCDS CCDS10166.1
PIR A28997
RefSeq NP_000227.2
XP_005254429.1
UniGene Hs.654472
ProteinModelPortal P11150
SMR P11150
BioGrid 110178
IntAct P11150
STRING 9606.ENSP00000299022
BindingDB P11150
ChEMBL CHEMBL2127
ESTHER human-LIPC
PhosphoSite P11150
BioMuta LIPC
DMDM 317373430
PaxDb P11150
PRIDE P11150
DNASU 3990
Ensembl ENST00000299022
ENST00000356113
GeneID 3990
KEGG hsa:3990
UCSC uc002afa.2
CTD 3990
GeneCards GC15P058702
H-InvDB HIX0038150
HGNC HGNC:6619
HPA CAB016141
MIM 125853
151670
612797
614025
neXtProt NX_P11150
Orphanet 140905
PharmGKB PA230
eggNOG NOG81747
GeneTree ENSGT00760000119069
HOGENOM HOG000038553
HOVERGEN HBG002259
InParanoid P11150
KO K01046
OrthoDB EOG757CX5
PhylomeDB P11150
TreeFam TF324997
ChiTaRS LIPC
GeneWiki Hepatic_lipase
GenomeRNAi 3990
NextBio 15652
PRO PR:P11150
Proteomes UP000005640
Bgee P11150
CleanEx HS_LIPC
ExpressionAtlas P11150
Genevisible P11150
GO GO:0005615
GO:0034364
GO:0034185
GO:0008201
GO:0030169
GO:0004620
GO:0004806
GO:0042632
GO:0008203
GO:0034382
GO:0006633
GO:0034375
GO:0034373
GO:0034374
GO:0034638
GO:0043691
GO:0019433
GO:0070328
GO:0034372
Gene3D 2.60.60.20
3.40.50.1820
InterPro IPR029058
IPR002333
IPR016272
IPR008976
IPR013818
IPR001024
IPR000734
PANTHER PTHR11610
PTHR11610:SF2
Pfam PF00151
PF01477
PIRSF PIRSF000865
PRINTS PR00824
PR00821
SMART SM00308
SUPFAM SSF49723
SSF53474
PROSITE PS00120
PS50095

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070328

triglyceride homeostasis

PMID:1883393[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043691

reverse cholesterol transport

PMID:14531818[2]

ECO:0000305

curator inference used in manual assertion

GO:0019433

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

PMID:1883393[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

PMID:3244012[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034374

low-density lipoprotein particle remodeling

PMID:3244012[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034372

very-low-density lipoprotein particle remodeling

PMID:8640403[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0034185

apolipoprotein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07867

F

Seeded From UniProt

complete

enables

GO:0030169

low-density lipoprotein particle binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07867

F

Seeded From UniProt

complete

involved_in

GO:0019433

triglyceride catabolic process

PMID:182536[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019433

triglyceride catabolic process

PMID:8640403[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019433

triglyceride catabolic process

PMID:2839510[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

PMID:182536[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:2839510[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004806

triglyceride lipase activity

PMID:182536[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004806

triglyceride lipase activity

PMID:2839510[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27656
ensembl:ENSMUSP00000034731

P

Seeded From UniProt

complete

involved_in

GO:0030301

cholesterol transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27656
ensembl:ENSMUSP00000034731

P

Seeded From UniProt

complete

enables

GO:0016298

lipase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27656
ensembl:ENSMUSP00000034731

F

Seeded From UniProt

complete

involved_in

GO:0008203

cholesterol metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27656
ensembl:ENSMUSP00000034731

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P27656
ensembl:ENSMUSP00000034731

C

Seeded From UniProt

complete

enables

GO:0004806

triglyceride lipase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002333

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002333
InterPro:IPR016272
InterPro:IPR033906

P

Seeded From UniProt

complete

enables

GO:0052689

carboxylic ester hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000734
InterPro:IPR016272

F

Seeded From UniProt

complete

enables

GO:0004806

triglyceride lipase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.3

F

Seeded From UniProt

complete

involved_in

GO:0034638

phosphatidylcholine catabolic process

PMID:2839510[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034382

chylomicron remnant clearance

PMID:9685400[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034373

intermediate-density lipoprotein particle remodeling

PMID:2839510[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004620

phospholipase activity

PMID:3244012[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051004

regulation of lipoprotein lipase activity

Reactome:R-HSA-8963889

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-6785181
Reactome:R-HSA-6785178

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6785213
Reactome:R-HSA-6785178
Reactome:R-HSA-5694109

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0345

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0442

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Hegele, RA et al. (1991) Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency. Biochem. Biophys. Res. Commun. 179 78-84 PubMed GONUTS page
  2. ↑ Kimura, H et al. (2003) Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels. Kidney Int. 64 1829-37 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Demant, T et al. (1988) Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein. J. Lipid Res. 29 1603-11 PubMed GONUTS page
  4. ↑ 4.0 4.1 Mowri, HO et al. (1996) Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase. Arterioscler. Thromb. Vasc. Biol. 16 755-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Kinnunen, PK & Ehnolm, C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett. 65 354-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Martin, GA et al. (1988) Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase. J. Biol. Chem. 263 10907-14 PubMed GONUTS page
  7. ↑ Choi, SY et al. (1998) Interaction between ApoB and hepatic lipase mediates the uptake of ApoB-containing lipoproteins. J. Biol. Chem. 273 20456-62 PubMed GONUTS page
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