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HUMAN:LICH
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LIPA | |
| Protein Name(s) | Lysosomal acid lipase/cholesteryl ester hydrolase
Acid cholesteryl ester hydrolase LAL Cholesteryl esterase Lipase A Sterol esterase | |
| External Links | ||
| UniProt | P38571 | |
| EMBL | M74775 U04285 U04286 U04287 U04288 U04290 U04291 U04292 U04293 X76488 Z31690 U08464 AK314665 AK222760 AL353751 AL353146 AL513533 AL353751 AL513533 AL353146 AL353751 AL513533 AL513533 AL353146 AL353751 AL513533 AL353751 CH471066 CH471066 CH471066 BC012287 | |
| CCDS | CCDS7401.1 | |
| PIR | G01416 S41408 | |
| RefSeq | NP_000226.2 NP_001121077.1 NP_001275908.1 | |
| UniGene | Hs.643030 | |
| ProteinModelPortal | P38571 | |
| SMR | P38571 | |
| BioGrid | 110176 | |
| STRING | 9606.ENSP00000337354 | |
| BindingDB | P38571 | |
| ChEMBL | CHEMBL4184 | |
| MEROPS | S33.017 | |
| PhosphoSite | P38571 | |
| DMDM | 68067636 | |
| MaxQB | P38571 | |
| PaxDb | P38571 | |
| PRIDE | P38571 | |
| DNASU | 3988 | |
| Ensembl | ENST00000336233 ENST00000371837 | |
| GeneID | 3988 | |
| KEGG | hsa:3988 | |
| UCSC | uc001kga.4 uc001kgb.4 | |
| CTD | 3988 | |
| GeneCards | GC10M090963 | |
| HGNC | HGNC:6617 | |
| HPA | CAB034892 | |
| MIM | 278000 613497 | |
| neXtProt | NX_P38571 | |
| Orphanet | 75234 75233 | |
| PharmGKB | PA30391 | |
| eggNOG | COG0596 | |
| GeneTree | ENSGT00550000074328 | |
| HOVERGEN | HBG006265 | |
| InParanoid | P38571 | |
| KO | K01052 | |
| OMA | FCTSPLA | |
| OrthoDB | EOG71RXJN | |
| PhylomeDB | P38571 | |
| TreeFam | TF315485 | |
| SABIO-RK | P38571 | |
| ChiTaRS | LIPA | |
| GenomeRNAi | 3988 | |
| NextBio | 15646 | |
| PRO | PR:P38571 | |
| Proteomes | UP000005640 | |
| Bgee | P38571 | |
| CleanEx | HS_LIPA | |
| ExpressionAtlas | P38571 | |
| Genevestigator | P38571 | |
| GO | GO:0070062 GO:0005764 GO:0016298 GO:0004771 GO:0000902 GO:0008283 GO:0001816 GO:0048873 GO:0006954 GO:0016042 GO:0030324 GO:0048771 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR000073 IPR006693 IPR025483 | |
| Pfam | PF04083 PF00561 | |
| PIRSF | PIRSF000862 | |
| SUPFAM | SSF53474 | |
| PROSITE | PS00120 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0016298 |
lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004771 |
sterol esterase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044255 |
cellular lipid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002591693 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000109216 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016298 |
lipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002591693 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016125 |
sterol metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001335706 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004771 |
sterol esterase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001335706 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001650 |
fibrillar center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048873 |
homeostasis of number of cells within a tissue |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048771 |
tissue remodeling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030324 |
lung development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001816 |
cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000902 |
cell morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z0M5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016788 |
hydrolase activity, acting on ester bonds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004771 |
sterol esterase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043202 |
lysosomal lumen |
Reactome:R-HSA-8865667 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034383 |
low-density lipoprotein particle clearance |
Reactome:R-HSA-8964038 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004771 |
sterol esterase activity |
Reactome:R-HSA-8865667 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Anderson, RA & Sando, GN (1991) Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases. J. Biol. Chem. 266 22479-84 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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