HUMAN:LCAT

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LCAT
Protein Name(s)	Phosphatidylcholine-sterol acyltransferase Lecithin-cholesterol acyltransferase Phospholipid-cholesterol acyltransferase
External Links
UniProt	P04180
EMBL	X04981 M12625 AY422210 BT009748 AC040162 CH471092 BC014781 M26268 X06537 M17959
CCDS	CCDS10854.1
PIR	A00571
RefSeq	NP_000220.1
UniGene	Hs.387239
PDB	4X96
PDBsum	4X96
ProteinModelPortal	P04180
SMR	P04180
BioGrid	110123
DIP	DIP-29620N
IntAct	P04180
STRING	9606.ENSP00000264005
BindingDB	P04180
ChEMBL	CHEMBL5942
ESTHER	human-LCAT
PhosphoSite	P04180
UniCarbKB	P04180
BioMuta	LCAT
DMDM	125993
MaxQB	P04180
PaxDb	P04180
PeptideAtlas	P04180
PRIDE	P04180
DNASU	3931
Ensembl	ENST00000264005
GeneID	3931
KEGG	hsa:3931
UCSC	uc002euy.1
CTD	3931
GeneCards	GC16M067973
H-InvDB	HIX0134431
HGNC	HGNC:6522
HPA	HPA044767
MIM	136120 245900 606967
neXtProt	NX_P04180
Orphanet	79293 79292
PharmGKB	PA226
eggNOG	NOG322613
GeneTree	ENSGT00390000004902
HOGENOM	HOG000238654
HOVERGEN	HBG017055
InParanoid	P04180
KO	K00650
OMA	FEDGWYM
PhylomeDB	P04180
TreeFam	TF313258
BRENDA	2.3.1.43
Reactome	REACT_13621
ChiTaRS	LCAT
GeneWiki	Lecithin%E2%80%94cholesterol_acyltransferase
GenomeRNAi	3931
NextBio	15437
PRO	PR:P04180
Proteomes	UP000005640
Bgee	P04180
CleanEx	HS_LCAT
ExpressionAtlas	P04180
Genevisible	P04180
GO	GO:0070062 GO:0005576 GO:0005615 GO:0034364 GO:0034186 GO:0004607 GO:0004623 GO:0034435 GO:0042632 GO:0008203 GO:0030301 GO:0034375 GO:0042158 GO:0042157 GO:0006656 GO:0006644 GO:0090107 GO:0046688 GO:0051384 GO:0043691 GO:0044281 GO:0034372
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR003386
Pfam	PF02450
SUPFAM	SSF53474
PROSITE	PS00120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0046470	phosphatidylcholine metabolic process	PMID:26195816^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:26195816^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	PMID:26195816^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034435	cholesterol esterification	PMID:26195816^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034435	cholesterol esterification	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034435	cholesterol esterification	PMID:3458198^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:15210842^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:12167653^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:15654758^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:3104518^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0034186	apolipoprotein A-I binding	PMID:1587806^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006656	phosphatidylcholine biosynthetic process	PMID:11966470^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:3458198^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	PMID:4335615^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:10722751^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	PMID:11966470^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	PMID:10559507^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:10559507^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10559507^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	PMID:10559507^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090107	regulation of high-density lipoprotein particle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16301 ensembl:ENSMUSP00000038232	P	Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16301 ensembl:ENSMUSP00000038232	P	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16301 ensembl:ENSMUSP00000038232	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16301 ensembl:ENSMUSP00000038232	C	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16301 ensembl:ENSMUSP00000038232	F	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003386	P	Seeded From UniProt	complete
enables	GO:0008374	O-acyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003386	F	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.43	F	Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	Reactome:R-HSA-8964058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-266315 Reactome:R-HSA-266310 Reactome:R-HSA-264695 Reactome:R-HSA-264689 Reactome:R-HSA-264678	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Reactome:R-HSA-264695	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P	Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Piper, DE et al. (2015) The high-resolution crystal structure of human LCAT. J. Lipid Res. 56 1711-9 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Fielding, CJ et al. (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem. Biophys. Res. Commun. 46 1493-8 PubMed GONUTS page
↑ ^4.0 ^4.1 McLean, J et al. (1986) Cloning and expression of human lecithin-cholesterol acyltransferase cDNA. Proc. Natl. Acad. Sci. U.S.A. 83 2335-9 PubMed GONUTS page
↑ Webb, NR et al. (2004) Remodeling of HDL remnants generated by scavenger receptor class B type I. J. Lipid Res. 45 1666-73 PubMed GONUTS page
↑ Li, HH et al. (2002) ApoA-I structure on discs and spheres. Variable helix registry and conformational states. J. Biol. Chem. 277 39093-101 PubMed GONUTS page
↑ Zhao, Y et al. (2005) Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry 44 1013-25 PubMed GONUTS page
↑ Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page
↑ Furukawa, Y et al. (1992) Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles. J. Biochem. 111 413-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Wang, K & Subbaiah, PV (2002) Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase. Biochem. J. 365 649-57 PubMed GONUTS page
↑ Clay, MA et al. (2000) Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase. J. Biol. Chem. 275 9019-25 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Fournier, N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147 227-35 PubMed GONUTS page

[PMID:26195816-1] 1.0 ^1.1 ^1.2 ^1.3 Piper, DE et al. (2015) The high-resolution crystal structure of human LCAT. J. Lipid Res. 56 1711-9 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:4335615-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Fielding, CJ et al. (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem. Biophys. Res. Commun. 46 1493-8 PubMed GONUTS page

[PMID:3458198-4] 4.0 ^4.1 McLean, J et al. (1986) Cloning and expression of human lecithin-cholesterol acyltransferase cDNA. Proc. Natl. Acad. Sci. U.S.A. 83 2335-9 PubMed GONUTS page

[PMID:15210842-5] Webb, NR et al. (2004) Remodeling of HDL remnants generated by scavenger receptor class B type I. J. Lipid Res. 45 1666-73 PubMed GONUTS page

[PMID:12167653-6] Li, HH et al. (2002) ApoA-I structure on discs and spheres. Variable helix registry and conformational states. J. Biol. Chem. 277 39093-101 PubMed GONUTS page

[PMID:15654758-7] Zhao, Y et al. (2005) Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry 44 1013-25 PubMed GONUTS page

[PMID:3104518-8] Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page

[PMID:1587806-9] Furukawa, Y et al. (1992) Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles. J. Biochem. 111 413-8 PubMed GONUTS page

[PMID:11966470-10] 10.0 ^10.1 Wang, K & Subbaiah, PV (2002) Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase. Biochem. J. 365 649-57 PubMed GONUTS page

[PMID:10722751-11] Clay, MA et al. (2000) Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase. J. Biol. Chem. 275 9019-25 PubMed GONUTS page

[PMID:10559507-12] 12.0 ^12.1 ^12.2 ^12.3 Fournier, N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147 227-35 PubMed GONUTS page

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HUMAN:LCAT

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