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HUMAN:LAMC1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LAMC1 (synonyms: LAMB2) | |
| Protein Name(s) | Laminin subunit gamma-1
Laminin B2 chain Laminin-1 subunit gamma Laminin-10 subunit gamma Laminin-11 subunit gamma Laminin-2 subunit gamma Laminin-3 subunit gamma Laminin-4 subunit gamma Laminin-6 subunit gamma Laminin-7 subunit gamma Laminin-8 subunit gamma Laminin-9 subunit gamma S-laminin subunit gamma S-LAM gamma | |
| External Links | ||
| UniProt | P11047 | |
| EMBL | J03202 M55210 M55217 M55201 M55211 M55212 M55213 M55214 M55215 M55216 M55192 M55193 M55194 M55195 M55196 M55197 M55198 M55199 M55200 M55202 M55203 M55204 M55205 M55206 M55207 M55208 M55209 AL354953 AL450304 AL450304 AL354953 X13939 M27654 | |
| CCDS | CCDS1351.1 | |
| PIR | S13548 | |
| RefSeq | NP_002284.3 | |
| UniGene | Hs.609663 | |
| ProteinModelPortal | P11047 | |
| SMR | P11047 | |
| BioGrid | 110109 | |
| IntAct | P11047 | |
| MINT | MINT-1184520 | |
| STRING | 9606.ENSP00000258341 | |
| ChEMBL | CHEMBL2364187 | |
| PhosphoSite | P11047 | |
| DMDM | 224471885 | |
| MaxQB | P11047 | |
| PaxDb | P11047 | |
| PRIDE | P11047 | |
| Ensembl | ENST00000258341 | |
| GeneID | 3915 | |
| KEGG | hsa:3915 | |
| UCSC | uc001gpy.4 | |
| CTD | 3915 | |
| GeneCards | GC01P182992 | |
| H-InvDB | HIX0001405 | |
| HGNC | HGNC:6492 | |
| HPA | CAB004486 HPA001908 HPA001909 | |
| MIM | 150290 | |
| neXtProt | NX_P11047 | |
| PharmGKB | PA30280 | |
| eggNOG | NOG235720 | |
| GeneTree | ENSGT00760000118860 | |
| HOGENOM | HOG000019301 | |
| HOVERGEN | HBG100808 | |
| InParanoid | P11047 | |
| KO | K05635 | |
| OMA | ATDYPWR | |
| OrthoDB | EOG7SR4KJ | |
| PhylomeDB | P11047 | |
| TreeFam | TF352481 | |
| Reactome | REACT_118572 REACT_163874 REACT_163906 REACT_169262 REACT_22205 | |
| ChiTaRS | LAMC1 | |
| GeneWiki | Laminin,_gamma_1 | |
| GenomeRNAi | 3915 | |
| NextBio | 15381 | |
| PRO | PR:P11047 | |
| Proteomes | UP000005640 | |
| Bgee | P11047 | |
| CleanEx | HS_LAMB2 HS_LAMC1 | |
| ExpressionAtlas | P11047 | |
| Genevestigator | P11047 | |
| GO | GO:0005604 GO:0031012 GO:0005576 GO:0005615 GO:0070062 GO:0005606 GO:0043259 GO:0043260 GO:0005201 GO:0043208 GO:0007411 GO:0007155 GO:0016477 GO:0007492 GO:0022617 GO:0030198 GO:0031581 GO:0050679 GO:0006461 GO:0034446 | |
| Gene3D | 2.60.120.260 | |
| InterPro | IPR013032 IPR002049 IPR008979 IPR018031 IPR000034 IPR008211 | |
| Pfam | PF00052 PF00053 PF00055 | |
| SMART | SM00180 SM00281 SM00136 | |
| PROSITE | PS00022 PS01186 PS01248 PS50027 PS51115 PS51117 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0001496) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
occurs_in:(UBERON:0002084) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0003688)|part_of:(UBERON:0001911) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0003688)|occurs_in:(UBERON:0001911) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030023 |
extracellular matrix constituent conferring elasticity |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0002107) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057)|part_of:(CL:0002322) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001003) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034446 |
substrate adhesion-dependent cell spreading |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001496) |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
part_of:(UBERON:0002084) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031581 |
hemidesmosome assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022617 |
extracellular matrix disassembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0065003 |
protein-containing complex assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005201 |
extracellular matrix structural constituent |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002367) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005606 |
laminin-1 complex |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1MAA7 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1MAA7 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005606 |
laminin-1 complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:F1MAA7 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007492 |
endoderm development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043260 |
laminin-11 complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043259 |
laminin-10 complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050679 |
positive regulation of epithelial cell proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005606 |
laminin-1 complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
Reactome:R-HSA-1474244 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-8952289 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-4084507 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
- ↑ 2.0 2.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ 3.0 3.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
- ↑ 4.0 4.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
- ↑ 5.0 5.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
- ↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Sage, J et al. (2012) Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PLoS ONE 7 e43494 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Vainionpää, N et al. (2006) Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am. J. Physiol., Cell Physiol. 290 C764-75 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 Breitkreutz, D et al. (2004) Inhibition of basement membrane formation by a nidogen-binding laminin gamma1-chain fragment in human skin-organotypic cocultures. J. Cell. Sci. 117 2611-22 PubMed GONUTS page
- ↑ Ishibashi, M et al. (2005) The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. Exp. Cell Res. 302 244-52 PubMed GONUTS page
- ↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
- ↑ 16.0 16.1 Champliaud, MF et al. (2000) Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta. Exp. Cell Res. 259 326-35 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Virtanen, I et al. (2003) Laminin isoforms in fetal and adult human adrenal cortex. J. Clin. Endocrinol. Metab. 88 4960-6 PubMed GONUTS page
- ↑ 18.0 18.1 Smyth, N et al. (1999) Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J. Cell Biol. 144 151-60 PubMed GONUTS page
c
e
- GO:0007492 ! endoderm development
- GO:0005788 ! endoplasmic reticulum lumen
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0005576 ! extracellular region
- GO:0030198 ! extracellular matrix organization
- GO:0005201 ! extracellular matrix structural constituent
- GO:0005615 ! extracellular space
- GO:0022617 ! extracellular matrix disassembly
- GO:0070062 ! extracellular exosome
- GO:0030023 ! extracellular matrix constituent conferring elasticity
- GO:0031012 ! extracellular matrix
p
