HUMAN:KIT

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KIT (synonyms: SCFR)
Protein Name(s)	Mast/stem cell growth factor receptor Kit SCFR Piebald trait protein PBT Proto-oncogene c-Kit Tyrosine-protein kinase Kit p145 c-kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
External Links
UniProt	P10721
EMBL	X06182 X69301 X69302 X69303 X69304 X69305 X69306 X69307 X69308 X69309 X69310 X69311 X69312 X69313 X69314 X69315 X69316 U63834 U63834 EU826594 GU983671 HM015525 HM015526 AK304031 AC006552 AC092545 BC071593 S67773
CCDS	CCDS3496.1 CCDS47058.1
PIR	S01426
RefSeq	NP_000213.1 NP_001087241.1
UniGene	Hs.479754
PDB	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4U0I
PDBsum	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4U0I
ProteinModelPortal	P10721
SMR	P10721
BioGrid	110015
DIP	DIP-1055N
IntAct	P10721
MINT	MINT-146746
STRING	9606.ENSP00000288135
BindingDB	P10721
ChEMBL	CHEMBL1936
DrugBank	DB01254 DB00619 DB04868 DB06589 DB08901 DB08896 DB00398 DB01268
GuidetoPHARMACOLOGY	1805
PhosphoSite	P10721
DMDM	125472
MaxQB	P10721
PaxDb	P10721
PRIDE	P10721
DNASU	3815
Ensembl	ENST00000288135 ENST00000412167
GeneID	3815
KEGG	hsa:3815
UCSC	uc010igr.3 uc010igs.3
CTD	3815
GeneCards	GC04P055524
HGNC	HGNC:6342
HPA	CAB003288 HPA004471
MIM	164920 172800 273300 601626 606764
neXtProt	NX_P10721
Orphanet	98834 98829 102724 158799 280785 158796 79455 44890 158778 158793 158772 2884 158769 280794 158775 98849 90389 158766
PharmGKB	PA30128
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000112008
HOVERGEN	HBG104348
InParanoid	P10721
KO	K05091
OMA	YFCPGTE
OrthoDB	EOG7S7SCZ
PhylomeDB	P10721
TreeFam	TF325768
BRENDA	2.7.10.1
Reactome	REACT_111040 REACT_111225 REACT_147727 REACT_75829
SignaLink	P10721
ChiTaRS	KIT
EvolutionaryTrace	P10721
GeneWiki	CD117
GenomeRNAi	3815
NextBio	14995
PRO	PR:P10721
Proteomes	UP000005640
Bgee	P10721
CleanEx	HS_KIT
ExpressionAtlas	P10721
Genevestigator	P10721
GO	GO:0001669 GO:0005911 GO:0009898 GO:0009897 GO:0005615 GO:0016021 GO:0042629 GO:0005886 GO:0005524 GO:0019955 GO:0046872 GO:0042803 GO:0004713 GO:0004716 GO:0005020 GO:0004714 GO:0031532 GO:0000187 GO:0060326 GO:0097067 GO:0019221 GO:0002371 GO:0050910 GO:0048565 GO:0035234 GO:0035162 GO:0007173 GO:0050673 GO:0030218 GO:0038162 GO:0038093 GO:0038095 GO:0008543 GO:0008354 GO:0006687 GO:0030097 GO:0002327 GO:0006954 GO:0045087 GO:0038109 GO:0030032 GO:0002320 GO:0008584 GO:0002551 GO:0032762 GO:0043303 GO:0060374 GO:0070662 GO:0035855 GO:0097326 GO:0030318 GO:0097324 GO:0002318 GO:0043069 GO:0048011 GO:0001541 GO:0018108 GO:0048015 GO:0043473 GO:0030335 GO:0008284 GO:0010628 GO:0046427 GO:0048170 GO:0043410 GO:0045747 GO:0043552 GO:0014068 GO:0010863 GO:0031274 GO:0051091 GO:0042511 GO:0042517 GO:0042523 GO:0046777 GO:0042127 GO:0008360 GO:0048070 GO:0007165 GO:0023014 GO:0048103 GO:0035019 GO:0007286 GO:0007283 GO:0048863 GO:0019827 GO:0030217 GO:0008542
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR003599 IPR003598 IPR013151 IPR011009 IPR000719 IPR017441 IPR027263 IPR001245 IPR008266 IPR020635 IPR016243 IPR001824
Pfam	PF00047 PF07714
PIRSF	PIRSF500951 PIRSF000615
SMART	SM00409 SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109 PS00240

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1905065	positive regulation of vascular smooth muscle cell differentiation	PMID:19088079^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0002591)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:14625290^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097326	melanocyte adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0097324	melanocyte migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0060374	mast cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:1721869^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:21135090^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:21640708^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:21135090^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21640708^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043303	mast cell degranulation	PMID:20100931^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21640708^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10721	F		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:21135090^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038162	erythropoietin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0038109	Kit signaling pathway	PMID:17662946^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038093	Fc receptor signaling pathway	PMID:20100931^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035855	megakaryocyte development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0032762	mast cell cytokine production	PMID:20100931^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:1721869^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:21640708^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21640708^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:21640708^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:17848411^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21640708^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002551	mast cell chemotaxis	PMID:20100931^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002371	dendritic cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0002327	immature B cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05532	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21640708^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:97531 PANTHER:PTN001230896 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814378 UniProtKB:P10721	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 MGI:MGI:1339758 MGI:MGI:96677 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96677 PANTHER:PTN002814378 UniProtKB:P10721	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0038109	Kit signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96677 PANTHER:PTN002814378 UniProtKB:P10721	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814378 RGD:620568	P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96677 PANTHER:PTN002814378	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 RGD:2965 RGD:3284 RGD:3285 RGD:620568 UniProtKB:P07333 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95559 MGI:MGI:96677 MGI:MGI:97530 PANTHER:PTN001230732	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043303	C		Seeded From UniProt	complete
involved_in	GO:0097326	melanocyte adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0097324	melanocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0097067	cellular response to thyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0060374	mast cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0048070	regulation of developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0043069	negative regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	F		Seeded From UniProt	complete
involved_in	GO:0038162	erythropoietin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0035855	megakaryocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0035701	hematopoietic stem cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0035234	ectopic germ cell programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0007286	spermatid development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0006687	glycosphingolipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	C		Seeded From UniProt	complete
enables	GO:0005020	stem cell factor receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	F		Seeded From UniProt	complete
involved_in	GO:0002573	myeloid leukocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0002371	dendritic cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0002327	immature B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0002320	lymphoid progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:0002318	myeloid progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	F		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05532 ensembl:ENSMUSP00000005815	P		Seeded From UniProt	complete
involved_in	GO:1904349	positive regulation of small intestine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:1904343	positive regulation of colon smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:1904251	regulation of bile acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0120072	positive regulation of pyloric antrum smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0050673	epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0048103	somatic stem cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0043586	tongue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0031274	positive regulation of pseudopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0008354	germ cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	F		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63116 ensembl:ENSRNOP00000003050	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824 InterPro:IPR027263	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001824 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR001824 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	P		Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027263	F		Seeded From UniProt	complete
involved_in	GO:0038093	Fc receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027263	P		Seeded From UniProt	complete
involved_in	GO:0038109	Kit signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027263	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9990072^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1717985^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070662	mast cell proliferation	PMID:21057534^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060374	mast cell differentiation	PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21057534^[12] PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	PMID:21057534^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:21057534^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010863	positive regulation of phospholipase C activity	PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:16129412^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	Reactome:R-HSA-8866910	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8864698 Reactome:R-HSA-5672965 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-205328 Reactome:R-HSA-205321 Reactome:R-HSA-205319 Reactome:R-HSA-205306 Reactome:R-HSA-205289 Reactome:R-HSA-205286 Reactome:R-HSA-205262 Reactome:R-HSA-205244 Reactome:R-HSA-205238 Reactome:R-HSA-205234 Reactome:R-HSA-205231 Reactome:R-HSA-1562641 Reactome:R-HSA-1562640 Reactome:R-HSA-1472121 Reactome:R-HSA-1470012 Reactome:R-HSA-1470010 Reactome:R-HSA-1470009 Reactome:R-HSA-1433542 Reactome:R-HSA-1433514 Reactome:R-HSA-1433508 Reactome:R-HSA-1433506 Reactome:R-HSA-1433501 Reactome:R-HSA-1433488 Reactome:R-HSA-1433471 Reactome:R-HSA-1433456 Reactome:R-HSA-1433454 Reactome:R-HSA-1433451 Reactome:R-HSA-1433428 Reactome:R-HSA-1433423 Reactome:R-HSA-1433418	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Davis, BN et al. (2009) Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J. Biol. Chem. 284 3728-38 PubMed GONUTS page
↑ Cruz, AC et al. (2004) Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells. J. Biol. Chem. 279 5612-20 PubMed GONUTS page
↑ ^3.0 ^3.1 Blume-Jensen, P et al. (1991) Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J. 10 4121-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Chaix, A et al. (2011) Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. J. Biol. Chem. 286 5956-66 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Kim, SY et al. (2011) Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816. Biochem. Biophys. Res. Commun. 410 224-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Kataoka, TR et al. (2010) CD72 negatively regulates KIT-mediated responses in human mast cells. J. Immunol. 184 2468-75 PubMed GONUTS page
↑ Yuzawa, S et al. (2007) Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell 130 323-34 PubMed GONUTS page
↑ O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Longley, BJ Jr et al. (1999) Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc. Natl. Acad. Sci. U.S.A. 96 1609-14 PubMed GONUTS page
↑ Giebel, LB & Spritz, RA (1991) Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc. Natl. Acad. Sci. U.S.A. 88 8696-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Pittoni, P et al. (2011) Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors. Oncogene 30 757-69 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Roskoski, R Jr (2005) Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. Biochem. Biophys. Res. Commun. 337 1-13 PubMed GONUTS page

[PMID:19088079-1] Davis, BN et al. (2009) Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J. Biol. Chem. 284 3728-38 PubMed GONUTS page

[PMID:14625290-2] Cruz, AC et al. (2004) Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells. J. Biol. Chem. 279 5612-20 PubMed GONUTS page

[PMID:1721869-3] 3.0 ^3.1 Blume-Jensen, P et al. (1991) Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J. 10 4121-8 PubMed GONUTS page

[PMID:21135090-4] 4.0 ^4.1 ^4.2 Chaix, A et al. (2011) Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. J. Biol. Chem. 286 5956-66 PubMed GONUTS page

[PMID:21640708-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Kim, SY et al. (2011) Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816. Biochem. Biophys. Res. Commun. 410 224-8 PubMed GONUTS page

[PMID:20100931-6] 6.0 ^6.1 ^6.2 ^6.3 Kataoka, TR et al. (2010) CD72 negatively regulates KIT-mediated responses in human mast cells. J. Immunol. 184 2468-75 PubMed GONUTS page

[PMID:17662946-7] Yuzawa, S et al. (2007) Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell 130 323-34 PubMed GONUTS page

[PMID:17848411-8] O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9990072-10] Longley, BJ Jr et al. (1999) Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc. Natl. Acad. Sci. U.S.A. 96 1609-14 PubMed GONUTS page

[PMID:1717985-11] Giebel, LB & Spritz, RA (1991) Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc. Natl. Acad. Sci. U.S.A. 88 8696-9 PubMed GONUTS page

[PMID:21057534-12] 12.0 ^12.1 ^12.2 ^12.3 Pittoni, P et al. (2011) Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors. Oncogene 30 757-69 PubMed GONUTS page

[PMID:16129412-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Roskoski, R Jr (2005) Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. Biochem. Biophys. Res. Commun. 337 1-13 PubMed GONUTS page

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HUMAN:KIT

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