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HUMAN:KISS1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KISS1
Protein Name(s) Metastasis-suppressor KiSS-1

Kisspeptin-1 Metastin Kisspeptin-54 Kisspeptin-14 Kisspeptin-13 Kisspeptin-10

External Links
UniProt Q15726
EMBL U43527
AY117143
AF218017
AL592114
AK291695
BC022819
CCDS CCDS41454.1
RefSeq NP_002247.3
UniGene Hs.95008
ProteinModelPortal Q15726
BioGrid 110014
STRING 9606.ENSP00000356162
PhosphoSite Q15726
PaxDb Q15726
PRIDE Q15726
DNASU 3814
Ensembl ENST00000367194
GeneID 3814
KEGG hsa:3814
UCSC uc001har.3
CTD 3814
GeneCards GC01M204159
GeneReviews KISS1
HGNC HGNC:6341
HPA CAB017775
HPA035542
MIM 603286
614842
neXtProt NX_Q15726
Orphanet 432
PharmGKB PA30127
eggNOG NOG28509
GeneTree ENSGT00390000008827
HOGENOM HOG000013123
HOVERGEN HBG052261
InParanoid Q15726
OMA FLCATHF
OrthoDB EOG79GT8B
PhylomeDB Q15726
TreeFam TF338233
Reactome REACT_14819
REACT_18283
ChiTaRS KISS1
GeneWiki Kisspeptin
GenomeRNAi 3814
NextBio 14991
PMAP-CutDB Q15726
PRO PR:Q15726
Proteomes UP000005640
Bgee Q15726
CleanEx HS_KISS1
Genevestigator Q15726
GO GO:0005576
GO:0007010
InterPro IPR020207
Pfam PF15152
ProDom PD088121

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0043005

neuron projection

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002704209
RGD:727850

C

Seeded From UniProt

complete

enables

GO:0031773

kisspeptin receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002704209
RGD:727850

F

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002704209
RGD:727850

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2663985
PANTHER:PTN002704209
RGD:727850

P

Seeded From UniProt

complete

involved_in

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

involved_in

GO:0060112

generation of ovulation cycle rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

involved_in

GO:0050806

positive regulation of synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

involved_in

GO:0043410

positive regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

C

Seeded From UniProt

complete

involved_in

GO:0033686

positive regulation of luteinizing hormone secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

enables

GO:0031773

kisspeptin receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TSB7
ensembl:ENSRNOP00000068332

C

Seeded From UniProt

complete

involved_in

GO:0007010

cytoskeleton organization

PMID:9192814[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-388981
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Lee, JH & Welch, DR (1997) Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res. 57 2384-7 PubMed GONUTS page