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HUMAN:KIRR3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KIRREL3 (ECO:0000312 with HGNC:HGNC:23204)
Protein Name(s) Kin of IRRE-like protein 3

Kin of irregular chiasm-like protein 3 Nephrin-like protein 2 (ECO:0000303 with PMID:12424224[1]) Processed kin of IRRE-like protein 3 (ECO:0000250 with UniProtKB:Q8BR86)

External Links
UniProt Q8IZU9
EMBL AF480410
AB058770
AY358743
AY358760
BC101775
BC101801
CCDS CCDS53723.1
CCDS55796.1
RefSeq NP_001155179.1
NP_115920.1
XP_011541333.1
XP_016873909.1
UniGene Hs.376015
PDB 2CRY
PDBsum 2CRY
ProteinModelPortal Q8IZU9
SMR Q8IZU9
STRING 9606.ENSP00000435466
iPTMnet Q8IZU9
PhosphoSitePlus Q8IZU9
BioMuta KIRREL3
DMDM 55736065
PaxDb Q8IZU9
PeptideAtlas Q8IZU9
PRIDE Q8IZU9
Ensembl ENST00000525144
ENST00000525704
GeneID 84623
KEGG hsa:84623
UCSC uc001qea.4
CTD 84623
DisGeNET 84623
GeneCards KIRREL3
HGNC HGNC:23204
HPA HPA053324
HPA056320
MalaCards KIRREL3
MIM 607761
612581
neXtProt NX_Q8IZU9
OpenTargets ENSG00000149571
Orphanet 178469
PharmGKB PA134958283
eggNOG KOG3510
ENOG410XPX0
GeneTree ENSGT00550000074545
HOGENOM HOG000020211
HOVERGEN HBG052260
InParanoid Q8IZU9
OMA GTEMKSG
OrthoDB EOG091G02BJ
PhylomeDB Q8IZU9
TreeFam TF327139
Reactome [www.reactome.org/content/detail/R-HSA-373753 R-HSA-373753]
ChiTaRS KIRREL3
EvolutionaryTrace Q8IZU9
GeneWiki KIRREL3
GenomeRNAi 84623
PRO PR:Q8IZU9
Proteomes UP000005640
Bgee ENSG00000149571
CleanEx HS_KIRREL3
ExpressionAtlas Q8IZU9
Genevisible Q8IZU9
GO GO:0030424
GO:0030425
GO:0043198
GO:0005576
GO:0016021
GO:0005886
GO:0072102
GO:0030097
GO:0021766
GO:0007156
GO:0002121
GO:0001764
GO:0048812
GO:0021740
GO:0007416
Gene3D 2.60.40.10
InterPro IPR007110
IPR013783
IPR013098
IPR003599
IPR003598
Pfam PF07679
PF13895
SMART SM00409
SM00408
SUPFAM SSF48726
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008021

synaptic vesicle

PMID:25902260[2]

ECO:0000314

C

Organism: Homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3

Fig 7 KIRREL3 colocalizes with the synaptic vesicles marker synaptophysin.

complete
CACAO 12564

Colocalizes with

GO:0043005

neuron projection

PMID:25902260[2]

ECO:0000316

UniProtKB:P46821


C

Organism: Homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3 w/ Protein: MAP1BLC1//MAP1B Figure 4: The co-localization occurs in punctuate structures across the length of entire neurite processes

complete
CACAO 12565

Colocalizes with

GO:0043005

neuron projection

PMID:25902260[2]

ECO:0000316

UniProtKB:Q9Y6X6


C

Organism: Homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3 w/ MYO16//MYO16 Figure 4: The colocalization across in punctuate structures across the length of entire neurite processes.

complete
CACAO 12566

Colocalizes with

GO:0005737

cytoplasm

PMID:25902260[2]

ECO:0000316

UniProtKB:P46821


C

Organism: Homo sapiens Protein: Kirrel3// Kin of IRRE-like protein 3 w/ Protein: MAP1BLC1//MAP1B Figure 4: Together, both visual inspection, as well as quantitative colocalization analyses of the images confirmed the colocalization of KIRREL3 with MAP1BLC1 in selected areas of the cytoplasm

complete
CACAO 12567

Colocalizes with

GO:0005737

cytoplasm

PMID:25902260[2]

ECO:0000316

UniProtKB:P05026


C

Organism: homo sapiens Protein: Kirrel 3// Kin of IRRE-like protein 3 w/ Protein: ATP1B1//ATP1B1 Figure 5: Immunostaining revealed the partial colocalization of KIRREL3 with ATP1B1 in selected areas in the cytoplasm

complete
CACAO 12568

Colocalizes with

GO:0043005

neuron projection

PMID:25902260[2]

ECO:0000316

UniProtKB:P05026


C

Organism: Homo sapiens Protein: Kirrel3// Kin of IRRE-like protein 3 w/ Protein: ATP1B1//ATP1B1 Figure 5: Immunostaining revealed the partial colocalization of KIRREL3 with ATP1B1 in punctate structures along the entire length of neurite processes.

complete
CACAO 12569

Colocalizes with

GO:0005737

cytoplasm

PMID:25902260[2]

ECO:0000316

UniProtKB:Q9Y3C8


C

Organism: homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3 w/ Protein UFC1//UFC1 Figure 5: Immunostaining revealed the partial colocalization of KIRREL3 with UFC1 in selected areas of the cytoplasm

complete
CACAO 12570

part_of

GO:0030425

dendrite

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

C

Seeded From UniProt

complete

Colocalizes with

GO:0043005

neuron projection

PMID:25902260[2]

ECO:0000316

UniProtKB:Q9Y3C8


C

Organism: homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3 w/ Protein: UFC1//UFC1 Figure 5: Immunostaining revealed the partial colocalization of KIRREL3 with UFC1 inpunctate structures along the entire length of neurite processes

complete
CACAO 12571

part_of

GO:0030424

axon

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

C

Seeded From UniProt

complete

Colocalizes with

GO:0005737

cytoplasm

PMID:25902260[2]

ECO:0000316

UniProtKB:P34897


C

Organism: homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3 w/ Protein: SHMT2//SHMT2 Figure 5: Immunostaining revealed the partial colocalization of KIRREL3 with SHMT2 in selected regions of the cytoplasm.

complete
CACAO 12572

involved_in

GO:0007416

synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

P

Seeded From UniProt

complete

Colocalizes with

GO:0043005

neuron projection

PMID:25902260[2]

ECO:0000316

UniProtKB:P34897


C

Organism: homo sapiens Protein: Kirrel3//Kin of IRRE-like protein 3 w/ Protein: SHMT2//SHMT2 Figure 5: Immunostaining revealed the partial colocalization of KIRREL3 with SHMT2 in punctate structures along the entire length of neurite processes.

complete
CACAO 12573

involved_in

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

P

Seeded From UniProt

complete

involved_in

GO:0021766

hippocampus development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

P

Seeded From UniProt

complete

involved_in

GO:0030097

hemopoiesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BR86

C

Seeded From UniProt

complete

involved_in

GO:0072102

glomerulus morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

involved_in

GO:0048812

neuron projection morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

part_of

GO:0043198

dendritic shaft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

C

Seeded From UniProt

complete

involved_in

GO:0030097

hemopoiesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

involved_in

GO:0021766

hippocampus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

involved_in

GO:0021740

principal sensory nucleus of trigeminal nerve development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

C

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

involved_in

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

C

Seeded From UniProt

complete

involved_in

GO:0002121

inter-male aggressive behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BR86
ensembl:ENSMUSP00000140219

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-451757

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Sellin, L et al. (2003) NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 17 115-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Liu, YF et al. (2015) Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment. PLoS ONE 10 e0123106 PubMed GONUTS page
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