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HUMAN:KIFA3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KIFAP3 (synonyms: KIF3AP, SMAP)
Protein Name(s) Kinesin-associated protein 3

KAP-3 KAP3 Smg GDS-associated protein

External Links
UniProt Q92845
EMBL U59919
AK297368
AK303052
AK315586
AL356475
AL121714
AL356475
AL121714
AL121714
AL356475
AL121714
AL356475
CH471067
CH471067
CH471067
BC028679
CCDS CCDS1288.1
CCDS55659.1
CCDS55660.1
CCDS55661.1
RefSeq NP_001191443.1
NP_001191445.1
NP_001191446.1
NP_055785.2
UniGene Hs.433442
ProteinModelPortal Q92845
BioGrid 116582
IntAct Q92845
MINT MINT-6942059
STRING 9606.ENSP00000354560
PhosphoSite Q92845
DMDM 73920216
MaxQB Q92845
PaxDb Q92845
PRIDE Q92845
DNASU 22920
Ensembl ENST00000361580
ENST00000367765
ENST00000367767
ENST00000538366
GeneID 22920
KEGG hsa:22920
UCSC uc001ggv.3
uc001ggw.2
CTD 22920
GeneCards GC01M169890
HGNC HGNC:17060
HPA HPA023738
HPA023742
MIM 601836
neXtProt NX_Q92845
PharmGKB PA30111
eggNOG NOG283482
GeneTree ENSGT00390000003574
HOGENOM HOG000012952
HOVERGEN HBG052257
InParanoid Q92845
OMA KCKLIHP
OrthoDB EOG7B5WVK
PhylomeDB Q92845
TreeFam TF314964
Reactome REACT_121399
REACT_147867
REACT_25201
SignaLink Q92845
ChiTaRS KIFAP3
GeneWiki KIFAP3
GenomeRNAi 22920
NextBio 43621
PRO PR:Q92845
Proteomes UP000005640
Bgee Q92845
CleanEx HS_KIFAP3
ExpressionAtlas Q92845
Genevestigator Q92845
GO GO:0005813
GO:0000794
GO:0005829
GO:0005783
GO:0070062
GO:0030990
GO:0016939
GO:0015630
GO:0019894
GO:0019886
GO:0007596
GO:0061024
GO:0007018
GO:0007017
GO:0043066
GO:0008285
GO:0072383
GO:0046587
GO:0006461
GO:0008104
GO:0007165
Gene3D 1.25.10.10
InterPro IPR011989
IPR016024
IPR000225
IPR008658
PANTHER PTHR15605
SMART SM00185
SUPFAM SSF48371
PROSITE PS50176

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005813

centrosome

PMID:16298999[1]

ECO:0000314

C

Immunoblotting during cell cycle show KAP3 at centosomes during interphase fig 4

complete

GO:0042301

phosphate binding

PMID:16298999[1]

ECO:0000314

F

Figure 1 shows larger molecule in presence in mitotic cells, which are reduced by BAP but not in presence of phosphatatse inhibitors

complete

GO:0005515

protein binding

PMID:16298999[1]

ECO:0000021

UniProtKB:Q9Y496


F

Figure 2 shows immunopptation of KIF3a/3b complex with KAP3 and fig 3 shows separate immunoppt of kif3a

complete

GO:0008022

protein C-terminus binding

PMID:16298999[1]

ECO:0000021

UniProtKB:Q9Y496


F

Fig 3a shows failed immunoppt with mutant lacking c terminus of KIF3a, also inferred from mutant phenotype Species confirmed in PMID11912492

complete

GO:0005515

protein binding

PMID:16298999[1]

ECO:0000021

UniProtKB:Q9NQT8


F

Figure 2 shows immunopptation of KIF3a/3b complex with KAP3 and fig 3 shows separate immunoppt of kif3b

complete

GO:0008022

protein C-terminus binding

PMID:16298999[1]

ECO:0000021

UniProtKB:Q9NQT8


F

Fig 3a shows failed immunoppt with mutant lacking c terminus of KIF3b, also inferred from mutant phenotype Species confirmed in PMID11912492

complete

GO:0006461

protein complex assembly

ECO:0000304

P

Source: ProtInc

Missing: reference

enables

GO:0019903

protein phosphatase binding

PMID:24338362[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8WY54

F

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

PMID:24338362[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49593

F

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:16298999[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y496

F

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

PMID:16298999[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O15066

F

Seeded From UniProt

complete

part_of

GO:0016939

kinesin II complex

PMID:16298999[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

PMID:16298999[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005876

spindle microtubule

PMID:16298999[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:16298999[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:16298999[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016939

kinesin II complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P70188

C

Seeded From UniProt

complete

involved_in

GO:0007017

microtubule-based process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P70188

P

Seeded From UniProt

complete

part_of

GO:1990075

periciliary membrane compartment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

enables

GO:0120170

intraciliary transport particle B binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

F

Seeded From UniProt

complete

involved_in

GO:0046587

positive regulation of calcium-dependent cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

P

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

part_of

GO:0032391

photoreceptor connecting cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

part_of

GO:0016939

kinesin II complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

P

Seeded From UniProt

complete

involved_in

GO:0008104

protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

P

Seeded From UniProt

complete

involved_in

GO:0007017

microtubule-based process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

P

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70188
ensembl:ENSMUSP00000027877

C

Seeded From UniProt

complete

part_of

GO:0005871

kinesin complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008658

C

Seeded From UniProt

complete

enables

GO:0019894

kinesin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008658

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:8900189[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

PMID:8900189[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:8900189[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072383

plus-end-directed vesicle transport along microtubule

PMID:16298999[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0097542

ciliary tip

Reactome:R-HSA-5625426
Reactome:R-HSA-5625421
Reactome:R-HSA-5625416
Reactome:R-HSA-5624952

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

Reactome:R-HSA-5620924

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

Reactome:R-HSA-2132295

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007018

microtubule-based movement

Reactome:R-HSA-983189

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006890

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reactome:R-HSA-6811434

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

Reactome:R-HSA-5625426
Reactome:R-HSA-5625424
Reactome:R-HSA-5625416
Reactome:R-HSA-5624949

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-983266
Reactome:R-HSA-983259
Reactome:R-HSA-6811426
Reactome:R-HSA-6811423
Reactome:R-HSA-2213248

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Haraguchi, K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J. Biol. Chem. 281 4094-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Phang, HQ et al. (2014) POPX2 phosphatase regulates the KIF3 kinesin motor complex. J. Cell. Sci. 127 727-39 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Shimizu, K et al. (1996) SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. J. Biol. Chem. 271 27013-7 PubMed GONUTS page
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