HUMAN:KIF3A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KIF3A (synonyms: KIF3)
Protein Name(s)	Kinesin-like protein KIF3A Microtubule plus end-directed kinesin motor 3A
External Links
UniProt	Q9Y496
EMBL	AF041853 AB209780 AC004039 AC004237 BC045542
CCDS	CCDS34235.1
RefSeq	NP_001287720.1 NP_001287721.1 NP_008985.3
UniGene	Hs.43670
ProteinModelPortal	Q9Y496
SMR	Q9Y496
BioGrid	116300
DIP	DIP-33237N
IntAct	Q9Y496
STRING	9606.ENSP00000368020
ChEMBL	CHEMBL5544
PhosphoSite	Q9Y496
DMDM	296439481
MaxQB	Q9Y496
PaxDb	Q9Y496
PRIDE	Q9Y496
Ensembl	ENST00000378746
GeneID	11127
KEGG	hsa:11127
UCSC	uc003kxo.3
CTD	11127
GeneCards	GC05M132059
H-InvDB	HIX0024788
HGNC	HGNC:6319
HPA	CAB037085
MIM	604683
neXtProt	NX_Q9Y496
PharmGKB	PA30102
eggNOG	COG5059
GeneTree	ENSGT00770000120453
HOGENOM	HOG000116164
HOVERGEN	HBG052255
InParanoid	Q9Y496
KO	K10394
OrthoDB	EOG7WX086
PhylomeDB	Q9Y496
TreeFam	TF105223
Reactome	REACT_121399 REACT_147867 REACT_25201 REACT_267634
ChiTaRS	KIF3A
GeneWiki	KIF3A
GenomeRNAi	11127
NextBio	42288
PRO	PR:Q9Y496
Proteomes	UP000005640
Bgee	Q9Y496
CleanEx	HS_KIF3A
ExpressionAtlas	Q9Y496
Genevestigator	Q9Y496
GO	GO:0005813 GO:0005829 GO:0070062 GO:0016939 GO:0005874 GO:0015630 GO:0072372 GO:0005524 GO:0016887 GO:0003777 GO:0008574 GO:0030507 GO:0019886 GO:0006200 GO:0007596 GO:0042384 GO:0060271 GO:0061024 GO:0008152 GO:0007018 GO:0022008 GO:0006996 GO:0072383
Gene3D	3.40.850.10
InterPro	IPR027640 IPR019821 IPR001752 IPR027417
PANTHER	PTHR24115
Pfam	PF00225
PRINTS	PR00380
SMART	SM00129
SUPFAM	SSF52540
PROSITE	PS00411 PS50067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:16298999^[1]	ECO:0000021		UniProtKB:Q9NQT8	F		Figure 2 shows KIF3a and KIF3b as band together on immunoblotting with anti kif3a and antikif3b	complete
involved_in	GO:1902414	protein localization to cell junction	PMID:24338362^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_end_location:(GO:0005911) has_regulation_target:(UniProtKB:P19022)	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	PMID:24338362^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_end_location:(GO:0005911) has_regulation_target:(UniProtKB:P19022) part_of:(GO:1902414)	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:24338362^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49593	F		Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	PMID:26021297^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14966	F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
involved_in	GO:0034454	microtubule anchoring at centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28741	P		Seeded From UniProt	complete
involved_in	GO:0010457	centriole-centriole cohesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28741	P		Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:23386061^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0016939	kinesin II complex	PMID:16298999^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:16298999^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005876	spindle microtubule	PMID:16298999^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:16298999^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28741	C		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28741	P		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107689 PANTHER:PTN001190402 ZFIN:ZDB-GENE-050417-71	P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108426 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:621520 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:C8V3Q8 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 UniProtKB:Q96Q89 dictyBase:DDB_G0280967	F		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004380 PANTHER:PTN000650181	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000352 FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0011606 MGI:MGI:107689 MGI:MGI:108391 MGI:MGI:109564 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c PomBase:SPAC664.10 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:1304996 RGD:1306815 RGD:621538 RGD:621559 SGD:S000006345 TAIR:locus:2129630 TAIR:locus:2136437 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:O00139 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q02241 UniProtKB:Q0IMS9 UniProtKB:Q8NI77 UniProtKB:Q96Q89 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0276369	F		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004380 PANTHER:PTN000650181	P		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0004381 MGI:MGI:108426 MGI:MGI:2447072 PANTHER:PTN000648413 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 WB:WBGene00002222 WB:WBGene00002225 WB:WBGene00002230 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0281555	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000648413 RGD:1303035 RGD:1304996 RGD:621538 TAIR:locus:2089358 UniProtKB:O00139 UniProtKB:P52732 UniProtKB:Q02224 UniProtKB:Q15058 UniProtKB:Q9HAQ2 WB:WBGene00002228 WB:WBGene00003884 ZFIN:ZDB-GENE-991019-4	C		Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0004378 MGI:MGI:109202 MGI:MGI:1098229 PANTHER:PTN000648413 RGD:1303035 UniProtKB:D6XFK9 UniProtKB:O77382 UniProtKB:Q57UW8 UniProtKB:Q57X99 UniProtKB:Q582I0 WB:WBGene00003884	C		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0003545 MGI:MGI:108426 MGI:MGI:1098229 MGI:MGI:1098264 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c RGD:621559 SGD:S000000159 SGD:S000000787 TAIR:locus:2115713 UniProtKB:A0A0B4KFR5 UniProtKB:A0A1D8PT88 UniProtKB:O77382 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q0IMS9 UniProtKB:Q2M1P5 UniProtKB:Q5T7B8 UniProtKB:Q6YZ52 WB:WBGene00002222 WB:WBGene00002230 WB:WBGene00003884 WB:WBGene00006974 dictyBase:DDB_G0280967 dictyBase:DDB_G0291039	F		Seeded From UniProt	complete
enables	GO:0030507	spectrin binding	PMID:23704327^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008089	C		Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821	F		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752	F		Seeded From UniProt	complete
involved_in	GO:0006996	organelle organization	PMID:1447303^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072383	plus-end-directed vesicle transport along microtubule	PMID:16298999^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	PMID:16298999^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0097542	ciliary tip	Reactome:R-HSA-5625426 Reactome:R-HSA-5625421 Reactome:R-HSA-5625416 Reactome:R-HSA-5624952	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035735	intraciliary transport involved in cilium assembly	Reactome:R-HSA-5620924	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Reactome:R-HSA-2132295	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	Reactome:R-HSA-983189	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	Reactome:R-HSA-6811434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	Reactome:R-HSA-5625426 Reactome:R-HSA-5625424 Reactome:R-HSA-5625416 Reactome:R-HSA-5624949	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-984733 Reactome:R-HSA-983266 Reactome:R-HSA-983259 Reactome:R-HSA-6811426 Reactome:R-HSA-6811423 Reactome:R-HSA-2213248	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Haraguchi, K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J. Biol. Chem. 281 4094-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Phang, HQ et al. (2014) POPX2 phosphatase regulates the KIF3 kinesin motor complex. J. Cell. Sci. 127 727-39 PubMed GONUTS page
↑ Onnis, A et al. (2015) The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis. Cell Death Differ. 22 1687-99 PubMed GONUTS page
↑ Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page
↑ Aizawa, H et al. (1992) Kinesin family in murine central nervous system. J. Cell Biol. 119 1287-96 PubMed GONUTS page

[PMID:16298999-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Haraguchi, K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J. Biol. Chem. 281 4094-9 PubMed GONUTS page

[PMID:24338362-2] 2.0 ^2.1 ^2.2 Phang, HQ et al. (2014) POPX2 phosphatase regulates the KIF3 kinesin motor complex. J. Cell. Sci. 127 727-39 PubMed GONUTS page

[PMID:26021297-3] Onnis, A et al. (2015) The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis. Cell Death Differ. 22 1687-99 PubMed GONUTS page

[PMID:23386061-4] Kodani, A et al. (2013) Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 32 597-607 PubMed GONUTS page

[PMID:19056867-5] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23704327-7] Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page

[PMID:1447303-8] Aizawa, H et al. (1992) Kinesin family in murine central nervous system. J. Cell Biol. 119 1287-96 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

HUMAN:KIF3A

Contents

Annotations

Notes

References

a

c

e

h

i

k

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools