HUMAN:KI13B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KIF13B (synonyms: GAKIN, KIAA0639)
Protein Name(s)	Kinesin-like protein KIF13B Kinesin-like protein GAKIN
External Links
UniProt	Q9NQT8
EMBL	AF279865 AB014539 AK294837 AC084262 AC103830 AC108449 AL583912
CCDS	CCDS55217.1
RefSeq	NP_056069.2
UniGene	Hs.444767
PDB	2COW 3FM8 3GBJ 3MDB
PDBsum	2COW 3FM8 3GBJ 3MDB
ProteinModelPortal	Q9NQT8
SMR	Q9NQT8
BioGrid	116895
DIP	DIP-34586N
IntAct	Q9NQT8
STRING	9606.ENSP00000350459
PhosphoSite	Q9NQT8
DMDM	519668668
MaxQB	Q9NQT8
PaxDb	Q9NQT8
PRIDE	Q9NQT8
Ensembl	ENST00000524189
GeneID	23303
KEGG	hsa:23303
CTD	23303
GeneCards	GC08M028924
H-InvDB	HIX0021580
HGNC	HGNC:14405
HPA	HPA025023
MIM	607350
neXtProt	NX_Q9NQT8
PharmGKB	PA30099
eggNOG	COG5244
GeneTree	ENSGT00770000120451
HOGENOM	HOG000230729
HOVERGEN	HBG052244
InParanoid	Q9NQT8
KO	K17914
OMA	SNDPMQS
OrthoDB	EOG72G16D
PhylomeDB	Q9NQT8
TreeFam	TF105221
ChiTaRS	KIF13B
EvolutionaryTrace	Q9NQT8
GenomeRNAi	23303
NextBio	35471874
PRO	PR:Q9NQT8
Proteomes	UP000005640
CleanEx	HS_KIF13B
ExpressionAtlas	Q9NQT8
Genevestigator	Q9NQT8
GO	GO:0030424 GO:0005737 GO:0005871 GO:0005874 GO:0071889 GO:0005524 GO:0003777 GO:0019901 GO:0008152 GO:0007018 GO:0006605 GO:0050770 GO:0007165 GO:0042110
Gene3D	2.30.30.190 2.60.200.20 3.40.850.10
InterPro	IPR000938 IPR000253 IPR022140 IPR022164 IPR027640 IPR019821 IPR001752 IPR027417 IPR008984
PANTHER	PTHR24115
Pfam	PF01302 PF12473 PF00498 PF12423 PF00225
PRINTS	PR00380
SMART	SM01052 SM00240 SM00129
SUPFAM	SSF49879 SSF52540 SSF74924
PROSITE	PS00845 PS50245 PS00411 PS50067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005515	protein binding	PMID:16298999^[1]	ECO:0000021		UniProtKB:Q9Y496	F	Figure 2 shows KIF3a and KIF3b as band together on immunoblotting with anti kif3a and antikif3b	complete
	GO:0046602	regulation of mitotic centrosome separation	PMID:16298999^[1]	ECO:0000315			P	Fig 5a shows formation of higher numbers of centrosomes and abnormal separation, leading to aneuploidy cells (fig 5b) Species confirmed in PMID11912492	complete
enables	GO:0071889	14-3-3 protein binding	PMID:20194617^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	PMID:20194617^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:12496241^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:20194617^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20194617^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q7KZI7	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10859302^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P78352	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10859302^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10859302^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	PMID:10859302^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108426 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:621520 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:C8V3Q8 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 UniProtKB:Q96Q89 dictyBase:DDB_G0280967	F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000352 FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0011606 MGI:MGI:107689 MGI:MGI:108391 MGI:MGI:109564 MGI:MGI:1098226 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c PomBase:SPAC664.10 PomBase:SPBC1604.20c PomBase:SPBC1685.15c PomBase:SPBC2F12.13 RGD:1304996 RGD:1306815 RGD:621538 RGD:621559 SGD:S000006345 TAIR:locus:2129630 TAIR:locus:2136437 TAIR:locus:2148543 TAIR:locus:2157533 UniProtKB:O00139 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q02241 UniProtKB:Q0IMS9 UniProtKB:Q8NI77 UniProtKB:Q96Q89 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0276369	F	Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0004378 FB:FBgn0004381 MGI:MGI:108426 MGI:MGI:2447072 PANTHER:PTN000648413 UniProtKB:Q0IMS9 UniProtKB:Q6YZ52 UniProtKB:Q7X7H4 WB:WBGene00002222 WB:WBGene00002225 WB:WBGene00002230 WB:WBGene00006831 WB:WBGene00006974 dictyBase:DDB_G0281555	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004378 PANTHER:PTN000648413 RGD:1303035 RGD:1304996 RGD:621538 TAIR:locus:2089358 UniProtKB:O00139 UniProtKB:P52732 UniProtKB:Q02224 UniProtKB:Q15058 UniProtKB:Q9HAQ2 WB:WBGene00002228 WB:WBGene00003884 ZFIN:ZDB-GENE-991019-4	C	Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0004378 MGI:MGI:109202 MGI:MGI:1098229 PANTHER:PTN000648413 RGD:1303035 UniProtKB:D6XFK9 UniProtKB:O77382 UniProtKB:Q57UW8 UniProtKB:Q57X99 UniProtKB:Q582I0 WB:WBGene00003884	C	Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001308 FB:FBgn0002948 FB:FBgn0003545 MGI:MGI:108426 MGI:MGI:1098229 MGI:MGI:1098264 MGI:MGI:2447072 PANTHER:PTN000648413 PomBase:SPAC3A11.14c RGD:621559 SGD:S000000159 SGD:S000000787 TAIR:locus:2115713 UniProtKB:A0A0B4KFR5 UniProtKB:A0A1D8PT88 UniProtKB:O77382 UniProtKB:P17120 UniProtKB:P33176 UniProtKB:Q02224 UniProtKB:Q0IMS9 UniProtKB:Q2M1P5 UniProtKB:Q5T7B8 UniProtKB:Q6YZ52 WB:WBGene00002222 WB:WBGene00002230 WB:WBGene00003884 WB:WBGene00006974 dictyBase:DDB_G0280967 dictyBase:DDB_G0291039	F	Seeded From UniProt	complete
part_of	GO:0033270	paranode region of axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K8Z9 ensembl:ENSRNOP00000074800	C	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K8Z9 ensembl:ENSRNOP00000074800	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K8Z9 ensembl:ENSRNOP00000074800	C	Seeded From UniProt	complete
enables	GO:0003777	microtubule motor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821	F	Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752 InterPro:IPR019821 InterPro:IPR027640	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001752	F	Seeded From UniProt	complete
involved_in	GO:0007018	microtubule-based movement	PMID:10859302^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	PMID:10859302^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Haraguchi, K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J. Biol. Chem. 281 4094-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Yoshimura, Y et al. (2010) Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. Mol. Cell. Biol. 30 2206-19 PubMed GONUTS page
↑ Asaba, N et al. (2003) Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. J. Biol. Chem. 278 8395-400 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hanada, T et al. (2000) GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J. Biol. Chem. 275 28774-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16298999-1] 1.0 ^1.1 Haraguchi, K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J. Biol. Chem. 281 4094-9 PubMed GONUTS page

[PMID:20194617-2] 2.0 ^2.1 ^2.2 ^2.3 Yoshimura, Y et al. (2010) Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. Mol. Cell. Biol. 30 2206-19 PubMed GONUTS page

[PMID:12496241-3] Asaba, N et al. (2003) Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. J. Biol. Chem. 278 8395-400 PubMed GONUTS page

[PMID:10859302-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hanada, T et al. (2000) GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J. Biol. Chem. 275 28774-84 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:KI13B

Contents

Annotations

Notes

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