HUMAN:KCNQ1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KCNQ1 (ECO:0000312 with HGNC:HGNC:6294)
Protein Name(s)	Potassium voltage-gated channel subfamily KQT member 1 (ECO:0000305) IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 (ECO:0000305 with PMID:9312006^[1]) KQT-like 1 (ECO:0000305) Voltage-gated potassium channel subunit Kv7.1 (ECO:0000305 with PMID:20533308^[2])
External Links
UniProt	P51787
EMBL	AF000571 AF051426 AB015163 AB015163 AJ006345 AJ006345 AY114213 AK290618 AC013791 AC021424 AC124055 AC124057 AP006463 KF455303 KF455304 KF455305 KF455306 KF459741 CH471158 BC113545 U86146 U89364
CCDS	CCDS7736.1
RefSeq	NP_000209.2 NP_861463.1
UniGene	Hs.95162
PDB	3BJ4 3HFC 3HFE 4UMO 4V0C
PDBsum	3BJ4 3HFC 3HFE 4UMO 4V0C
ProteinModelPortal	P51787
SMR	P51787
BioGrid	109985
DIP	DIP-27591N DIP-29941N
IntAct	P51787
MINT	MINT-1145466
STRING	9606.ENSP00000155840
BindingDB	P51787
ChEMBL	CHEMBL1866
DrugBank	DB04957 DB01244 DB06089 DB00808
GuidetoPHARMACOLOGY	560
TCDB	1.A.1.15.6
iPTMnet	P51787
PhosphoSitePlus	P51787
BioMuta	KCNQ1
DMDM	6166005
PaxDb	P51787
PeptideAtlas	P51787
PRIDE	P51787
DNASU	3784
Ensembl	ENST00000155840 ENST00000335475
GeneID	3784
KEGG	hsa:3784
UCSC	uc001lwn.4
CTD	3784
DisGeNET	3784
GeneCards	KCNQ1
GeneReviews	KCNQ1
HGNC	HGNC:6294
HPA	CAB018656 HPA048553
MalaCards	KCNQ1
MIM	125853 192500 220400 607542 607554 609621
neXtProt	NX_P51787
OpenTargets	ENSG00000053918
Orphanet	334 51083 90647 101016
PharmGKB	PA223
eggNOG	KOG1419 COG1226
GeneTree	ENSGT00550000074513
HOGENOM	HOG000220839
HOVERGEN	HBG059014
InParanoid	P51787
KO	K04926
OMA	EVSTPHF
OrthoDB	EOG091G02ZT
PhylomeDB	P51787
TreeFam	TF315186
Reactome	[www.reactome.org/content/detail/R-HSA-1296072 R-HSA-1296072] [www.reactome.org/content/detail/R-HSA-5576890 R-HSA-5576890] [www.reactome.org/content/detail/R-HSA-5576893 R-HSA-5576893]
SignaLink	P51787
ChiTaRS	KCNQ1
EvolutionaryTrace	P51787
GeneWiki	KvLQT1
GenomeRNAi	3784
PRO	PR:P51787
Proteomes	UP000005640
Bgee	ENSG00000053918
CleanEx	HS_KCNQ1
ExpressionAtlas	P51787
Genevisible	P51787
GO	GO:0016323 GO:0005737 GO:0030659 GO:0005769 GO:0005783 GO:0034702 GO:0005770 GO:0005764 GO:0045121 GO:0005886 GO:0008076 GO:0005516 GO:0005251 GO:0044325 GO:0015271 GO:0005546 GO:0034236 GO:0034237 GO:0008157 GO:0097110 GO:0005249 GO:0086089 GO:0086008 GO:1902282 GO:0086014 GO:0061337 GO:0060048 GO:0072358 GO:0071320 GO:0035690 GO:0071872 GO:0016458 GO:0048839 GO:0050892 GO:0086011 GO:0098914 GO:0086013 GO:0098915 GO:1902260 GO:1903817 GO:0060452 GO:0010460 GO:1901381 GO:0071435 GO:0097623 GO:0071805 GO:0060372 GO:0060453 GO:0006349 GO:0008016 GO:0086091 GO:0060306 GO:0060307 GO:0070293 GO:0007605 GO:0086005
Gene3D	1.20.120.350
InterPro	IPR027359 IPR005821 IPR003937 IPR013821 IPR005827 IPR028325
PANTHER	PTHR11537 PTHR11537:SF189
Pfam	PF00520 PF03520
PRINTS	PR00169 PR01460 PR01459

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential	PMID:12522251^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	PMID:25786344^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0006813	potassium ion transport	PMID:28264985^[5]	ECO:0000315			P		Maintains potassium uptake, dysfunction causes disease.	complete CACAO 12783
involved_in	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential	PMID:25786344^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:20533308^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:25705178^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:24855057^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:24855057^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034702	ion channel complex	PMID:24855057^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NR82	C		Seeded From UniProt	complete
colocalizes_with	GO:0005783	endoplasmic reticulum	PMID:24855057^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NR82	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:24855057^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NR82	F		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:25037568^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25037568^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:25037568^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25037568^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:25037568^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15382	F		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:24184248^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24184248^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:20196769^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15382	F		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:9312006^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22024150^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10646604^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21228319^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21228319^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97414	P		Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0N7	P		Seeded From UniProt	complete
involved_in	GO:0070293	renal absorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97414	P		Seeded From UniProt	complete
involved_in	GO:0060453	regulation of gastric acid secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97414	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25705178^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:24269949^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21228319^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:24855057^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:11101505^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15382 UniProtKB:Q9Y6J6	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:11101505^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15382	F		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:11101505^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:19646991^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010460	positive regulation of heart rate	PMID:19646991^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	PMID:19646991^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0005251	delayed rectifier potassium channel activity	PMID:19646991^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	PMID:19646991^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	PMID:18093912^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:18093912^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99996	F		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:16002409^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0005249	voltage-gated potassium channel activity	PMID:16002409^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:16002409^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	PMID:16002409^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:16002409^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99996	F		Seeded From UniProt	complete
colocalizes_with	GO:0005769	early endosome	PMID:23529131^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P20339	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23529131^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901381	positive regulation of potassium ion transmembrane transport	PMID:8900283^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:11799244^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99996	F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	PMID:12522251^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0086014	atrial cardiac muscle cell action potential	PMID:12522251^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086013	membrane repolarization during cardiac muscle cell action potential	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	PMID:11299204^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	PMID:8900283^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	PMID:12522251^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0086005	ventricular cardiac muscle cell action potential	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:11299204^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:9354802^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:17289006^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:10400998^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:8900283^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	PMID:11299204^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	PMID:12522251^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060306	regulation of membrane repolarization	PMID:8900283^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0060306	regulation of membrane repolarization	PMID:11299204^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:8528244^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:12324418^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJ90	F		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:9108097^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034237	protein kinase A regulatory subunit binding	PMID:11799244^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0034236	protein kinase A catalytic subunit binding	PMID:11799244^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21957902^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008157	protein phosphatase 1 binding	PMID:11799244^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:17289006^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:8900283^[21]	ECO:0000305	curator inference used in manual assertion	GO:0005251	C		Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	PMID:8900283^[21]	ECO:0000305	curator inference used in manual assertion	GO:0005251	P		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:21957902^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21957902^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21957902^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:18165683^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005251	delayed rectifier potassium channel activity	PMID:11299204^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005251	delayed rectifier potassium channel activity	PMID:9354802^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005251	delayed rectifier potassium channel activity	PMID:10400998^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:12522251^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005251	delayed rectifier potassium channel activity	PMID:8900283^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:17289006^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:8900283^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000165609 UniProtKB:P51787	F		Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000165609 UniProtKB:P51787	P		Seeded From UniProt	complete
enables	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000165609 UniProtKB:P51787	F		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102663 MGI:MGI:1336181 MGI:MGI:96654 MGI:MGI:96659 MGI:MGI:96666 PANTHER:PTN000164970 RGD:2949 RGD:2950 RGD:2951 RGD:2952 RGD:2953 RGD:2954 RGD:2955 RGD:62083 RGD:621349 RGD:621504 RGD:628829 RGD:631416 RGD:68393 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P16389 UniProtKB:P17658 UniProtKB:P22459 UniProtKB:P22460 UniProtKB:P51787 UniProtKB:Q09470 UniProtKB:Q14003 UniProtKB:Q14721 UniProtKB:Q8TAE7 UniProtKB:Q8TDN1 UniProtKB:Q9NR82 UniProtKB:Q9NZV8 UniProtKB:Q9UIX4 WB:WBGene00001374 WB:WBGene00014261	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003380 FB:FBgn0033494 PANTHER:PTN000164970 RGD:2952	C		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000165609 RGD:621503 UniProtKB:P51787	F		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003380 MGI:MGI:102663 MGI:MGI:1197011 MGI:MGI:1197019 MGI:MGI:1309503 MGI:MGI:1336181 MGI:MGI:96654 MGI:MGI:96659 MGI:MGI:96666 PANTHER:PTN001355853 RGD:2949 RGD:2950 RGD:2952 RGD:2953 RGD:2954 RGD:2955 RGD:62083 RGD:621349 RGD:621503 RGD:621504 RGD:628829 RGD:631416 RGD:68393 RGD:68394 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P16389 UniProtKB:P22459 UniProtKB:P22460 UniProtKB:P48547 UniProtKB:P51787 UniProtKB:Q09470 UniProtKB:Q14003 UniProtKB:Q14721 UniProtKB:Q8TAE7 UniProtKB:Q8TDN1 UniProtKB:Q96KK3 UniProtKB:Q9NR82 UniProtKB:Q9NZV8 UniProtKB:Q9UIX4 UniProtKB:Q9UK17	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1309503 MGI:MGI:1336181 PANTHER:PTN000899150 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P51787	F		Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000899150 RGD:621503 UniProtKB:P51787	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:21873635^[31]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108083 MGI:MGI:1924937 MGI:MGI:1926803 MGI:MGI:96654 MGI:MGI:96659 MGI:MGI:96662 PANTHER:PTN000164970 RGD:2949 RGD:2950 RGD:2951 RGD:2952 RGD:2954 RGD:621504 RGD:628829 RGD:628832 RGD:628848 RGD:68393 RGD:68394 RGD:69222 UniProtKB:O43525 UniProtKB:O43526 UniProtKB:P16389 UniProtKB:P22459 UniProtKB:P51787 UniProtKB:Q09470 UniProtKB:Q14003 UniProtKB:Q9NR82 UniProtKB:Q9NZV8 WB:WBGene00004793 ZFIN:ZDB-GENE-030131-5626	F		Seeded From UniProt	complete
involved_in	GO:0086009	membrane repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
involved_in	GO:0072358	cardiovascular system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
involved_in	GO:0070293	renal absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
involved_in	GO:0060453	regulation of gastric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	P		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97414 ensembl:ENSMUSP00000009689	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003937 InterPro:IPR005827 InterPro:IPR028325	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003937 InterPro:IPR005827 InterPro:IPR028325	P		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005827 InterPro:IPR028325	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003937 InterPro:IPR005821	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:9305853^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005249	P		Seeded From UniProt	complete
involved_in	GO:1902260	negative regulation of delayed rectifier potassium channel activity	PMID:9305853^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903817	negative regulation of voltage-gated potassium channel activity	PMID:9305853^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	PMID:9020846^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086013	membrane repolarization during cardiac muscle cell action potential	PMID:11299204^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071872	cellular response to epinephrine stimulus	PMID:11799244^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	Reactome:R-HSA-5576893 Reactome:R-HSA-5576890	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5577050 Reactome:R-HSA-1296127	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chouabe, C et al. (1997) Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J. 16 5472-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Roura-Ferrer, M et al. (2010) Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting. J. Cell. Physiol. 225 692-700 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chen, YH et al. (2003) KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299 251-4 PubMed GONUTS page
↑ ^4.0 ^4.1 Steffensen, AB et al. (2015) IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation. J. Cardiovasc. Electrophysiol. 26 715-23 PubMed GONUTS page
↑ Kapplinger, JD et al. (2017) KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1. J. Med. Genet. PubMed GONUTS page
↑ ^6.0 ^6.1 Mousavi Nik, A et al. (2015) Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome. Front Cell Neurosci 9 32 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Oliveras, A et al. (2014) Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology. Arterioscler. Thromb. Vasc. Biol. 34 1522-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Dvir, M et al. (2014) Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂. J. Cell. Sci. 127 3943-55 PubMed GONUTS page
↑ ^9.0 ^9.1 Wu, J et al. (2014) A molecular mechanism for adrenergic-induced long QT syndrome. J. Am. Coll. Cardiol. 63 819-27 PubMed GONUTS page
↑ Zheng, R et al. (2010) Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits. Biochem. J. 428 75-84 PubMed GONUTS page
↑ Krzystanek, K et al. (2012) Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart Rhythm 9 440-8 PubMed GONUTS page
↑ Schroeder, BC et al. (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403 196-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Andersen, MN et al. (2011) Kv7.1 surface expression is regulated by epithelial cell polarization. Am. J. Physiol., Cell Physiol. 300 C814-24 PubMed GONUTS page
↑ Bartos, DC et al. (2014) A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation. Heart Rhythm 11 459-68 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Wang, Q et al. (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12 17-23 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Tinel, N et al. (2000) KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 19 6326-30 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Abraham, RL et al. (2010) Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation. J. Mol. Cell. Cardiol. 48 181-90 PubMed GONUTS page
↑ ^18.0 ^18.1 Chen, L et al. (2007) Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc. Natl. Acad. Sci. U.S.A. 104 20990-5 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Chen, L et al. (2005) Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel. J. Biol. Chem. 280 31347-52 PubMed GONUTS page
↑ ^20.0 ^20.1 Rapetti-Mauss, R et al. (2013) Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium. J. Physiol. (Lond.) 591 2813-31 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Sanguinetti, MC et al. (1996) Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384 80-3 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Marx, SO et al. (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295 496-9 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Potet, F et al. (2001) AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am. J. Physiol. Heart Circ. Physiol. 280 H2038-45 PubMed GONUTS page
↑ ^24.0 ^24.1 Splawski, I et al. (1997) Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat. Genet. 17 338-40 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Jespersen, T et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res. 74 64-74 PubMed GONUTS page
↑ ^26.0 ^26.1 Bianchi, L et al. (1999) Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome. Hum. Mol. Genet. 8 1499-507 PubMed GONUTS page
↑ Angelo, K et al. (2002) KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Biophys. J. 83 1997-2006 PubMed GONUTS page
↑ Yang, WP et al. (1997) KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc. Natl. Acad. Sci. U.S.A. 94 4017-21 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Andersen, MN et al. (2012) AMP-activated protein kinase downregulates Kv7.1 cell surface expression. Traffic 13 143-56 PubMed GONUTS page
↑ Wiener, R et al. (2008) The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J. Biol. Chem. 283 5815-30 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 ^31.4 ^31.5 ^31.6 ^31.7 ^31.8 ^31.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Jiang, M et al. (1997) Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart. J. Biol. Chem. 272 24109-12 PubMed GONUTS page
↑ Neyroud, N et al. (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat. Genet. 15 186-9 PubMed GONUTS page

[PMID:9312006-1] 1.0 ^1.1 Chouabe, C et al. (1997) Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J. 16 5472-9 PubMed GONUTS page

[PMID:20533308-2] 2.0 ^2.1 Roura-Ferrer, M et al. (2010) Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting. J. Cell. Physiol. 225 692-700 PubMed GONUTS page

[PMID:12522251-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chen, YH et al. (2003) KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299 251-4 PubMed GONUTS page

[PMID:25786344-4] 4.0 ^4.1 Steffensen, AB et al. (2015) IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation. J. Cardiovasc. Electrophysiol. 26 715-23 PubMed GONUTS page

[PMID:28264985-5] Kapplinger, JD et al. (2017) KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1. J. Med. Genet. PubMed GONUTS page

[PMID:25705178-6] 6.0 ^6.1 Mousavi Nik, A et al. (2015) Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome. Front Cell Neurosci 9 32 PubMed GONUTS page

[PMID:24855057-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Oliveras, A et al. (2014) Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology. Arterioscler. Thromb. Vasc. Biol. 34 1522-30 PubMed GONUTS page

[PMID:25037568-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Dvir, M et al. (2014) Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂. J. Cell. Sci. 127 3943-55 PubMed GONUTS page

[PMID:24184248-9] 9.0 ^9.1 Wu, J et al. (2014) A molecular mechanism for adrenergic-induced long QT syndrome. J. Am. Coll. Cardiol. 63 819-27 PubMed GONUTS page

[PMID:20196769-10] Zheng, R et al. (2010) Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits. Biochem. J. 428 75-84 PubMed GONUTS page

[PMID:22024150-11] Krzystanek, K et al. (2012) Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart Rhythm 9 440-8 PubMed GONUTS page

[PMID:10646604-12] Schroeder, BC et al. (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403 196-9 PubMed GONUTS page

[PMID:21228319-13] 13.0 ^13.1 ^13.2 Andersen, MN et al. (2011) Kv7.1 surface expression is regulated by epithelial cell polarization. Am. J. Physiol., Cell Physiol. 300 C814-24 PubMed GONUTS page

[PMID:24269949-14] Bartos, DC et al. (2014) A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation. Heart Rhythm 11 459-68 PubMed GONUTS page

[PMID:8528244-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Wang, Q et al. (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12 17-23 PubMed GONUTS page

[PMID:11101505-16] 16.0 ^16.1 ^16.2 Tinel, N et al. (2000) KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 19 6326-30 PubMed GONUTS page

[PMID:19646991-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Abraham, RL et al. (2010) Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation. J. Mol. Cell. Cardiol. 48 181-90 PubMed GONUTS page

[PMID:18093912-18] 18.0 ^18.1 Chen, L et al. (2007) Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc. Natl. Acad. Sci. U.S.A. 104 20990-5 PubMed GONUTS page

[PMID:16002409-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Chen, L et al. (2005) Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel. J. Biol. Chem. 280 31347-52 PubMed GONUTS page

[PMID:23529131-20] 20.0 ^20.1 Rapetti-Mauss, R et al. (2013) Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium. J. Physiol. (Lond.) 591 2813-31 PubMed GONUTS page

[PMID:8900283-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Sanguinetti, MC et al. (1996) Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384 80-3 PubMed GONUTS page

[PMID:11799244-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Marx, SO et al. (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295 496-9 PubMed GONUTS page

[PMID:11299204-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Potet, F et al. (2001) AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am. J. Physiol. Heart Circ. Physiol. 280 H2038-45 PubMed GONUTS page

[PMID:9354802-24] 24.0 ^24.1 Splawski, I et al. (1997) Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat. Genet. 17 338-40 PubMed GONUTS page

[PMID:17289006-25] 25.0 ^25.1 ^25.2 Jespersen, T et al. (2007) The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res. 74 64-74 PubMed GONUTS page

[PMID:10400998-26] 26.0 ^26.1 Bianchi, L et al. (1999) Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome. Hum. Mol. Genet. 8 1499-507 PubMed GONUTS page

[PMID:12324418-27] Angelo, K et al. (2002) KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Biophys. J. 83 1997-2006 PubMed GONUTS page

[PMID:9108097-28] Yang, WP et al. (1997) KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc. Natl. Acad. Sci. U.S.A. 94 4017-21 PubMed GONUTS page

[PMID:21957902-29] 29.0 ^29.1 ^29.2 ^29.3 Andersen, MN et al. (2012) AMP-activated protein kinase downregulates Kv7.1 cell surface expression. Traffic 13 143-56 PubMed GONUTS page

[PMID:18165683-30] Wiener, R et al. (2008) The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J. Biol. Chem. 283 5815-30 PubMed GONUTS page

[PMID:21873635-31] 31.0 ^31.1 ^31.2 ^31.3 ^31.4 ^31.5 ^31.6 ^31.7 ^31.8 ^31.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9305853-32] 32.0 ^32.1 ^32.2 Jiang, M et al. (1997) Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart. J. Biol. Chem. 272 24109-12 PubMed GONUTS page

[PMID:9020846-33] Neyroud, N et al. (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat. Genet. 15 186-9 PubMed GONUTS page

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