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HUMAN:KAD4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AK4 (ECO:0000255 with HAMAP-Rule:MF_03170) (synonyms: AK3, AK3L1 (ECO:0000255 with HAMAP-Rule:MF_03170))
Protein Name(s) Adenylate kinase 4, mitochondrial (ECO:0000255 with HAMAP-Rule:MF_03170)

AK 4 (ECO:0000255 with HAMAP-Rule:MF_03170) Adenylate kinase 3-like (ECO:0000255 with HAMAP-Rule:MF_03170) GTP:AMP phosphotransferase AK4 (ECO:0000255 with HAMAP-Rule:MF_03170)

External Links
UniProt P27144
EMBL X60673
CR456830
AK313611
AL356212
AC099680
CH471059
CH471059
CH471059
BC016180
BC040224
BC066944
BC136886
BC136887
BC148270
BC146653
CCDS CCDS629.1
PIR A42820
RefSeq NP_001005353.1
NP_037542.1
NP_982289.1
XP_003119578.1
UniGene Hs.10862
PDB 2AR7
2BBW
3NDP
PDBsum 2AR7
2BBW
3NDP
ProteinModelPortal P27144
SMR P27144
BioGrid 106708
IntAct P27144
BindingDB P27144
ChEMBL CHEMBL4926
DrugBank DB00718
DB00300
PhosphoSite P27144
DMDM 125157
UCD-2DPAGE P27144
MaxQB P27144
PaxDb P27144
PRIDE P27144
DNASU 205
Ensembl ENST00000327299
ENST00000395334
ENST00000545314
GeneID 100507855
205
KEGG hsa:100507855
hsa:205
UCSC uc001dby.3
CTD 205
GeneCards GC01P065614
HGNC HGNC:363
HPA HPA042753
HPA049461
MIM 103030
neXtProt NX_P27144
PharmGKB PA165750325
eggNOG COG0563
GeneTree ENSGT00550000074679
HOGENOM HOG000238772
HOVERGEN HBG000458
InParanoid P27144
KO K00939
OMA IWPYINS
PhylomeDB P27144
TreeFam TF312916
EvolutionaryTrace P27144
GeneWiki AK3L1
NextBio 818
PRO PR:P27144
Proteomes UP000005640
Bgee P27144
CleanEx HS_AK3
HS_AK3L1
ExpressionAtlas P27144
Genevestigator P27144
GO GO:0070062
GO:0005759
GO:0005739
GO:0004017
GO:0005524
GO:0005525
GO:0004550
GO:0046899
GO:0006172
GO:0046033
GO:0046034
GO:0007420
GO:0046039
GO:0001889
GO:0006165
GO:0009142
GO:0042493
Gene3D 3.40.50.300
HAMAP MF_00235
MF_03169
MF_03170
InterPro IPR006259
IPR000850
IPR007862
IPR028586
IPR028585
IPR027417
PANTHER PTHR23359
Pfam PF05191
PRINTS PR00094
SUPFAM SSF52540
SSF57774
TIGRFAMs TIGR01351
PROSITE PS00113

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0046899

nucleoside triphosphate adenylate kinase activity

PMID:19766732[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|enables

GO:0046899

nucleoside triphosphate adenylate kinase activity

PMID:11485571[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046039

GTP metabolic process

PMID:19766732[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046034

ATP metabolic process

PMID:19766732[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046033

AMP metabolic process

PMID:19766732[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:11485571[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WUR9

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:19766732[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

PMID:19766732[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|enables

GO:0004017

adenylate kinase activity

PMID:11485571[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009142

nucleoside triphosphate biosynthetic process

PMID:23416111[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006165

nucleoside diphosphate phosphorylation

PMID:23416111[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004550

nucleoside diphosphate kinase activity

PMID:23416111[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0050145

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUR9
ensembl:ENSMUSP00000102559

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUS0
ensembl:ENSRNOP00000065349

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUS0
ensembl:ENSRNOP00000065349

P

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUS0
ensembl:ENSRNOP00000065349

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000850
InterPro:IPR006259

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028585
InterPro:IPR028586

C

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000850

P

Seeded From UniProt

complete

enables

GO:0016776

phosphotransferase activity, phosphate group as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006259

F

Seeded From UniProt

complete

enables

GO:0019205

nucleobase-containing compound kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000850

F

Seeded From UniProt

complete

enables

GO:0004550

nucleoside diphosphate kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.4.6

F

Seeded From UniProt

complete

involved_in

GO:0006172

ADP biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166132

P

Seeded From UniProt

complete

involved_in

GO:0046039

GTP metabolic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166132

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166132

C

Seeded From UniProt

complete

involved_in

GO:0046034

ATP metabolic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166132

P

Seeded From UniProt

complete

involved_in

GO:0046033

AMP metabolic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166132

P

Seeded From UniProt

complete

enables

GO:0050145

nucleoside monophosphate kinase activity

Reactome:R-HSA-6788798

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0015949

nucleobase-containing small molecule interconversion

Reactome:R-HSA-499943

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-6788798

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Panayiotou, C et al. (2010) Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4. Int. J. Biochem. Cell Biol. 42 62-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 Noma, T et al. (2001) Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Biochem. J. 358 225-32 PubMed GONUTS page
  3. 3.0 3.1 3.2 Amiri, M et al. (2013) The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int. J. Biochem. Cell Biol. 45 925-31 PubMed GONUTS page