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HUMAN:KAD4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | AK4 (ECO:0000255 with HAMAP-Rule:MF_03170) (synonyms: AK3, AK3L1 (ECO:0000255 with HAMAP-Rule:MF_03170)) | |
| Protein Name(s) | Adenylate kinase 4, mitochondrial (ECO:0000255 with HAMAP-Rule:MF_03170)
AK 4 (ECO:0000255 with HAMAP-Rule:MF_03170) Adenylate kinase 3-like (ECO:0000255 with HAMAP-Rule:MF_03170) GTP:AMP phosphotransferase AK4 (ECO:0000255 with HAMAP-Rule:MF_03170) | |
| External Links | ||
| UniProt | P27144 | |
| EMBL | X60673 CR456830 AK313611 AL356212 AC099680 CH471059 CH471059 CH471059 BC016180 BC040224 BC066944 BC136886 BC136887 BC148270 BC146653 | |
| CCDS | CCDS629.1 | |
| PIR | A42820 | |
| RefSeq | NP_001005353.1 NP_037542.1 NP_982289.1 XP_003119578.1 | |
| UniGene | Hs.10862 | |
| PDB | 2AR7 2BBW 3NDP | |
| PDBsum | 2AR7 2BBW 3NDP | |
| ProteinModelPortal | P27144 | |
| SMR | P27144 | |
| BioGrid | 106708 | |
| IntAct | P27144 | |
| BindingDB | P27144 | |
| ChEMBL | CHEMBL4926 | |
| DrugBank | DB00718 DB00300 | |
| PhosphoSite | P27144 | |
| DMDM | 125157 | |
| UCD-2DPAGE | P27144 | |
| MaxQB | P27144 | |
| PaxDb | P27144 | |
| PRIDE | P27144 | |
| DNASU | 205 | |
| Ensembl | ENST00000327299 ENST00000395334 ENST00000545314 | |
| GeneID | 100507855 205 | |
| KEGG | hsa:100507855 hsa:205 | |
| UCSC | uc001dby.3 | |
| CTD | 205 | |
| GeneCards | GC01P065614 | |
| HGNC | HGNC:363 | |
| HPA | HPA042753 HPA049461 | |
| MIM | 103030 | |
| neXtProt | NX_P27144 | |
| PharmGKB | PA165750325 | |
| eggNOG | COG0563 | |
| GeneTree | ENSGT00550000074679 | |
| HOGENOM | HOG000238772 | |
| HOVERGEN | HBG000458 | |
| InParanoid | P27144 | |
| KO | K00939 | |
| OMA | IWPYINS | |
| PhylomeDB | P27144 | |
| TreeFam | TF312916 | |
| EvolutionaryTrace | P27144 | |
| GeneWiki | AK3L1 | |
| NextBio | 818 | |
| PRO | PR:P27144 | |
| Proteomes | UP000005640 | |
| Bgee | P27144 | |
| CleanEx | HS_AK3 HS_AK3L1 | |
| ExpressionAtlas | P27144 | |
| Genevestigator | P27144 | |
| GO | GO:0070062 GO:0005759 GO:0005739 GO:0004017 GO:0005524 GO:0005525 GO:0004550 GO:0046899 GO:0006172 GO:0046033 GO:0046034 GO:0007420 GO:0046039 GO:0001889 GO:0006165 GO:0009142 GO:0042493 | |
| Gene3D | 3.40.50.300 | |
| HAMAP | MF_00235 MF_03169 MF_03170 | |
| InterPro | IPR006259 IPR000850 IPR007862 IPR028586 IPR028585 IPR027417 | |
| PANTHER | PTHR23359 | |
| Pfam | PF05191 | |
| PRINTS | PR00094 | |
| SUPFAM | SSF52540 SSF57774 | |
| TIGRFAMs | TIGR01351 | |
| PROSITE | PS00113 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0046899 |
nucleoside triphosphate adenylate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0046899 |
nucleoside triphosphate adenylate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046039 |
GTP metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046034 |
ATP metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046033 |
AMP metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004017 |
adenylate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0004017 |
adenylate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009142 |
nucleoside triphosphate biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006165 |
nucleoside diphosphate phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004550 |
nucleoside diphosphate kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046940 |
nucleoside monophosphate phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0050145 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046940 |
nucleoside monophosphate phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004017 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046940 |
nucleoside monophosphate phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004017 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUR9 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUS0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUS0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001889 |
liver development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUS0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006139 |
nucleobase-containing compound metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016776 |
phosphotransferase activity, phosphate group as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019205 |
nucleobase-containing compound kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004550 |
nucleoside diphosphate kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006172 |
ADP biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000166132 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046039 |
GTP metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000166132 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000166132 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046034 |
ATP metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000166132 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046033 |
AMP metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000166132 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0050145 |
nucleoside monophosphate kinase activity |
Reactome:R-HSA-6788798 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015949 |
nucleobase-containing small molecule interconversion |
Reactome:R-HSA-499943 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-6788798 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Panayiotou, C et al. (2010) Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4. Int. J. Biochem. Cell Biol. 42 62-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Noma, T et al. (2001) Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Biochem. J. 358 225-32 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Amiri, M et al. (2013) The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int. J. Biochem. Cell Biol. 45 925-31 PubMed GONUTS page
a
n
- GO:0015949 ! nucleobase-containing small molecule interconversion
- GO:0006139 ! nucleobase-containing compound metabolic process
- GO:0019205 ! nucleobase-containing compound kinase activity
- GO:0004550 ! nucleoside diphosphate kinase activity
- GO:0050145 ! nucleoside monophosphate kinase activity
- GO:0046940 ! nucleoside monophosphate phosphorylation
- GO:0009142 ! nucleoside triphosphate biosynthetic process
- GO:0046899 ! nucleoside triphosphate adenylate kinase activity
- GO:0000166 ! nucleotide binding
p
