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HUMAN:K2C75

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KRT75 (synonyms: K6HF, KB18)
Protein Name(s) Keratin, type II cytoskeletal 75

Cytokeratin-75 CK-75 Keratin-6 hair follicle hK6hf Keratin-75 K75 Type II keratin-K6hf Type-II keratin Kb18

External Links
UniProt O95678
EMBL Y17282
Y19212
AK298960
AC055736
CCDS CCDS8827.1
RefSeq NP_004684.2
UniGene Hs.697046
ProteinModelPortal O95678
SMR O95678
BioGrid 114567
IntAct O95678
Allergome 415
PhosphoSite O95678
MaxQB O95678
PaxDb O95678
PeptideAtlas O95678
PRIDE O95678
DNASU 9119
Ensembl ENST00000252245
GeneID 9119
KEGG hsa:9119
UCSC uc001saj.2
CTD 9119
GeneCards GC12M052817
H-InvDB HIX0036863
HGNC HGNC:24431
HPA HPA019367
MIM 600628
609025
612318
neXtProt NX_O95678
PharmGKB PA147357763
eggNOG NOG146769
GeneTree ENSGT00760000118796
HOGENOM HOG000230976
HOVERGEN HBG013015
InParanoid O95678
KO K07605
OMA RQSTITF
OrthoDB EOG7FV3Q8
PhylomeDB O95678
TreeFam TF317854
GenomeRNAi 9119
NextBio 34175
PRO PR:O95678
Proteomes UP000005640
Bgee O95678
CleanEx HS_KRT75
Genevestigator O95678
GO GO:0070062
GO:0045095
GO:0005198
GO:0002244
InterPro IPR001664
IPR018039
IPR003054
PANTHER PTHR23239
Pfam PF00038
PRINTS PR01276
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005882

intermediate filament

PMID:15086549[1]

ECO:0000314

C

Fig. 4a, "Cells transfected with K6hfWT/K17...Note the fully extended IF network in a"

complete
CACAO 3866

part_of

GO:0005882

intermediate filament

PMID:15086549[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BGZ7
ensembl:ENSMUSP00000036246

P

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

C

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003054

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

PMID:9856802[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070268

cornification

Reactome:R-HSA-6809371

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

Reactome:R-HSA-6805567

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8942224
Reactome:R-HSA-6814764
Reactome:R-HSA-6814734
Reactome:R-HSA-6814387
Reactome:R-HSA-6814298
Reactome:R-HSA-6811539
Reactome:R-HSA-6810937
Reactome:R-HSA-6810357
Reactome:R-HSA-6809663
Reactome:R-HSA-6809393
Reactome:R-HSA-6806629
Reactome:R-HSA-6806613
Reactome:R-HSA-6806610
Reactome:R-HSA-6805573
Reactome:R-HSA-6805546

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0403
UniProtKB-KW:KW-0416

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Winter, H et al. (2004) An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. J. Invest. Dermatol. 122 652-7 PubMed GONUTS page
  2. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. Winter, H et al. (1998) A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle. J. Invest. Dermatol. 111 955-62 PubMed GONUTS page