HUMAN:K2C74

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KRT74 (synonyms: K6IRS4, KB37, KRT5C, KRT6IRS4)
Protein Name(s)	Keratin, type II cytoskeletal 74 Cytokeratin-74 CK-74 Keratin-5c K5C Keratin-74 K74 Type II inner root sheath-specific keratin-K6irs4 Type-II keratin Kb37
External Links
UniProt	Q7RTS7
EMBL	AJ508777 AC055715 CH471054 BK000977
CCDS	CCDS8832.1
RefSeq	NP_778223.2
UniGene	Hs.660125
ProteinModelPortal	Q7RTS7
SMR	Q7RTS7
BioGrid	125727
STRING	9606.ENSP00000307240
PhosphoSite	Q7RTS7
DMDM	166218812
MaxQB	Q7RTS7
PaxDb	Q7RTS7
PRIDE	Q7RTS7
DNASU	121391
Ensembl	ENST00000305620
GeneID	121391
KEGG	hsa:121391
UCSC	uc001sap.1
CTD	121391
GeneCards	GC12M052959
H-InvDB	HIX0036697
HGNC	HGNC:28929
HPA	HPA048596
MIM	194300 608248 613981 614929
neXtProt	NX_Q7RTS7
Orphanet	90368 69084 170
PharmGKB	PA147357741
eggNOG	NOG266742
GeneTree	ENSGT00760000118796
HOGENOM	HOG000230976
HOVERGEN	HBG013015
InParanoid	Q7RTS7
KO	K07605
PhylomeDB	Q7RTS7
TreeFam	TF317854
GenomeRNAi	121391
NextBio	80732
PRO	PR:Q7RTS7
Proteomes	UP000005640
Bgee	Q7RTS7
CleanEx	HS_KRT74
ExpressionAtlas	Q7RTS7
Genevestigator	Q7RTS7
GO	GO:0005737 GO:0070062 GO:0045095 GO:1990254 GO:0005198 GO:0045104
InterPro	IPR001664 IPR018039 IPR003054
PANTHER	PTHR23239
Pfam	PF00038
PRINTS	PR01276
PROSITE	PS00226

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005737	cytoplasm	PMID:20346438	ECO:0000314			C		p.635 "antibodies demonstrate that Wt-K74 protein is widely distributed throughout the cytoplasm"	complete CACAO 3919
part_of	GO:0070062	extracellular exosome	PMID:23533145	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990254	keratin filament binding	PMID:20346438	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02533	F		Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	PMID:20346438	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20346438	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	F		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	C		Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003054	C		Seeded From UniProt	complete
involved_in	GO:0070268	cornification	Reactome:R-HSA-6809371	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031424	keratinization	Reactome:R-HSA-6805567	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8942224 Reactome:R-HSA-6814764 Reactome:R-HSA-6814734 Reactome:R-HSA-6814387 Reactome:R-HSA-6814298 Reactome:R-HSA-6811539 Reactome:R-HSA-6810937 Reactome:R-HSA-6810357 Reactome:R-HSA-6809663 Reactome:R-HSA-6809393 Reactome:R-HSA-6806629 Reactome:R-HSA-6806613 Reactome:R-HSA-6806610 Reactome:R-HSA-6805573 Reactome:R-HSA-6805546	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0416 UniProtKB-KW:KW-0403	C		Seeded From UniProt	complete
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References

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