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HUMAN:K1C25
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KRT25 (ECO:0000312 with HGNC:HGNC:30839) (synonyms: KRT25A (ECO:0000312 with EMBL:CAD91904.1)) | |
| Protein Name(s) | Keratin, type I cytoskeletal 25
Cytokeratin-25 CK-25 Keratin-25 K25 Keratin-25A K25A Type I inner root sheath-specific keratin-K25irs1 | |
| External Links | ||
| UniProt | Q7Z3Z0 | |
| EMBL | AJ564204 CH471152 | |
| CCDS | CCDS11373.1 | |
| RefSeq | NP_853512.1 | |
| UniGene | Hs.55412 | |
| ProteinModelPortal | Q7Z3Z0 | |
| SMR | Q7Z3Z0 | |
| BioGrid | 127044 | |
| PhosphoSite | Q7Z3Z0 | |
| DMDM | 74723316 | |
| MaxQB | Q7Z3Z0 | |
| PaxDb | Q7Z3Z0 | |
| PRIDE | Q7Z3Z0 | |
| DNASU | 147183 | |
| Ensembl | ENST00000312150 | |
| GeneID | 147183 | |
| KEGG | hsa:147183 | |
| UCSC | uc002hve.3 | |
| CTD | 147183 | |
| GeneCards | GC17M038904 | |
| H-InvDB | HIX0027280 | |
| HGNC | HGNC:30839 | |
| HPA | HPA053977 | |
| neXtProt | NX_Q7Z3Z0 | |
| PharmGKB | PA134977088 | |
| eggNOG | NOG149789 | |
| GeneTree | ENSGT00760000118808 | |
| HOGENOM | HOG000230975 | |
| HOVERGEN | HBG013015 | |
| InParanoid | Q7Z3Z0 | |
| KO | K07604 | |
| OMA | GNACGIP | |
| OrthoDB | EOG7FV3Q8 | |
| PhylomeDB | Q7Z3Z0 | |
| TreeFam | TF332742 | |
| GenomeRNAi | 147183 | |
| NextBio | 85566 | |
| PRO | PR:Q7Z3Z0 | |
| Proteomes | UP000005640 | |
| Bgee | Q7Z3Z0 | |
| CleanEx | HS_KRT25 | |
| Genevestigator | Q7Z3Z0 | |
| GO | GO:0005737 GO:0070062 GO:0005882 GO:0005198 GO:0007568 GO:0042633 GO:0031069 GO:0045109 | |
| InterPro | IPR001664 IPR002957 | |
| PANTHER | PTHR23239 | |
| Pfam | PF00038 | |
| PRINTS | PR01248 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0007010 |
cytoskeleton organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042633 |
hair cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007568 |
aging |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045109 |
intermediate filament organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCW2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031069 |
hair follicle morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCW2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005882 |
intermediate filament |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070268 |
cornification |
Reactome:R-HSA-6809371 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031424 |
keratinization |
Reactome:R-HSA-6805567 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8942224 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005882 |
intermediate filament |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zernov, NV et al. (2016) Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles. J. Invest. Dermatol. 136 1097-1105 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 3.0 3.1 Choi, HI et al. (2011) Hair greying is associated with active hair growth. Br. J. Dermatol. 165 1183-9 PubMed GONUTS page
- ↑ Yu, X et al. (2018) A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis. J. Invest. Dermatol. 138 230-233 PubMed GONUTS page
